{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:20:30Z","timestamp":1788337230899,"version":"build-2803163510"},"reference-count":30,"publisher":"Sociedade Brasileira de Cardiologia","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,3]]},"DOI":"10.36660\/abc.20200154","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T18:45:29Z","timestamp":1615401929000},"page":"404-412","source":"Crossref","is-referenced-by-count":4,"title":["Caracteriza\u00e7\u00e3o Histol\u00f3gica das Les\u00f5es da Valva Mitral de Pacientes com Cardiopatia Reum\u00e1tica"],"prefix":"10.36660","volume":"116","author":[{"given":"Nayana F. A.","family":"Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo A.","family":"Pascoal-Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia S. A.","family":"Passos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Mendon\u00e7a Nunes","family":"Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-4801","authenticated-orcid":false,"given":"Jo\u00e3o Marcelo de Souza","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-9624","authenticated-orcid":false,"given":"Felipe Vieira","family":"Guar\u00e7oni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4103-8446","authenticated-orcid":false,"given":"Maria Cec\u00edlia Landim","family":"Nassif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Leo","family":"Gelape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Braulio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Henrique N.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8260-9212","authenticated-orcid":false,"given":"Luiz Guilherme","family":"Passaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4153-1874","authenticated-orcid":false,"given":"Raquel Braga","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walderez O.","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-1828","authenticated-orcid":false,"given":"Maria Carmo P.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22636","reference":[{"issue":"8","key":"key20210310134523_B1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1056\/NEJMoa1603693","article-title":"Global, regional, and national burden of rheumatic heart disease, 1990-2015","volume":"377","author":"Watkins","year":"2017","unstructured":"1. Watkins DA, Johnson CO, Colquhoun SM, Karthikeyan G, Beaton A, Bukhman G, et al. Global, regional, and national burden of rheumatic heart disease, 1990-2015. N Engl J Med. 2017;377(8):713-22","journal-title":"N Engl J Med"},{"issue":"12","key":"key20210310134523_B2","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jacc.2018.06.063","article-title":"Rheumatic heart disease worldwide: Jacc scientific expert panel","volume":"72","author":"Watkins","year":"2018","unstructured":"2. Watkins DA, Beaton AZ, Carapetis JR, Karthikeyan G, Mayosi BM, Wyber R, et al. Rheumatic heart disease worldwide: Jacc scientific expert panel. J Am Coll Cardiol. 2018;72(12):1397-416","journal-title":"J Am Coll Cardiol"},{"key":"key20210310134523_B3","first-page":"52","article-title":"Rheumatic heart disease in the modern era: Recent developments and current challenges","author":"Leal","year":"2019","unstructured":"3. Leal MT, Passos LS, Guar\u00e7oni FV, Aguiar JM, Silva RB, Paula TM, et al. Rheumatic heart disease in the modern era: Recent developments and current challenges. Rev Soc Bras Med Trop. 2019;52","journal-title":"Rev Soc Bras Med Trop"},{"issue":"9963","key":"key20210310134523_B4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age\u2013sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: A systematic analysis for the global burden of disease study 2013","volume":"385","author":"Naghavi","year":"2015","unstructured":"4. Naghavi M, Wang H, Lozano R, Davis A, Liang X, Zhou M, et al. Global, regional, and national age\u2013sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: A systematic analysis for the global burden of disease study 2013. Lancet. 2015 Jan 10;385(9963):117-71.","journal-title":"Lancet"},{"issue":"19","key":"key20210310134523_B5","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/CIRCULATIONAHA.116.024769","article-title":"Clinical outcomes in 3343 children and adults with rheumatic heart disease from 14 low- and middle-income countries: Two-year follow-up of the global rheumatic heart disease registry (the remedy study)","volume":"134","author":"Zuhlke","year":"2016","unstructured":"5. Zuhlke L, Karthikeyan G, Engel ME, Rangarajan S, Mackie P, Cupido-Katya Mauff B, et al. Clinical outcomes in 3343 children and adults with rheumatic heart disease from 14 low- and middle-income countries: Two-year follow-up of the global rheumatic heart disease registry (the remedy study). Circulation. 2016 Nov 8;134(19):1456-66.","journal-title":"Circulation"},{"issue":"18","key":"key20210310134523_B6","doi-asserted-by":"crossref","first-page":"1115a","DOI":"10.1093\/eurheartj\/ehu449","article-title":"Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: The global rheumatic heart disease registry (the remedy study)","volume":"36","author":"Zuhlke","year":"2015","unstructured":"6. Zuhlke L, Engel ME, Karthikeyan G, Rangarajan S, Mackie P, Cupido B, et al. Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: The global rheumatic heart disease registry (the remedy study). Eur Heart J. 2015 May 7;36(18):1115-22a.","journal-title":"Eur Heart J"},{"issue":"18","key":"key20210310134523_B7","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/eurheartj\/ehu507","article-title":"The stark reality of rheumatic heart disease","volume":"36","author":"Carapetis","year":"2015","unstructured":"7. Carapetis JR. The stark reality of rheumatic heart disease. Eur Heart J. 2015 May 7;36(18):1070-3.","journal-title":"Eur Heart J"},{"issue":"10142","key":"key20210310134523_B8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0140-6736(18)30999-1","article-title":"Acute rheumatic fever","volume":"392","author":"Karthikeyan","year":"2018","unstructured":"8. Karthikeyan G, Guilherme L. Acute rheumatic fever. Lancet. 2018 Jul 14;392(10142):161-74.","journal-title":"Lancet"},{"issue":"3","key":"key20210310134523_B9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrcardio.2012.197","article-title":"Revisiting the pathogenesis of rheumatic fever and carditis","volume":"10","author":"Tandon","year":"2013","unstructured":"9. Tandon R, Sharma M, Chandrashekhar Y, Kotb M, Yacoub MH, Narula J. Revisiting the pathogenesis of rheumatic fever and carditis. Nat Rev Cardiol. 2013 Mar;10(3):171-7.","journal-title":"Nat Rev Cardiol"},{"key":"key20210310134523_B10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.hrtlng.2017.03.006","article-title":"Late mitral restenosis after percutaneous commissurotomy: Predictive value of inflammation and extracellular matrix remodeling biomarkers","volume":"46","author":"Mechmeche","year":"2017","unstructured":"10. Mechmeche R, Zaroui A, Aloui S, Boukhris M, Allal-Elasmi M, Kaabachi N, et al. Late mitral restenosis after percutaneous commissurotomy: Predictive value of inflammation and extracellular matrix remodeling biomarkers. Heart & Lung. 2017;46:258-64","journal-title":"Heart & Lung"},{"issue":"10","key":"key20210310134523_B11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s11886-016-0773-2","article-title":"Rheumatic heart disease in the twenty-first century","volume":"18","author":"Woldu","year":"2016","unstructured":"11. Woldu B, Bloomfield GS. Rheumatic heart disease in the twenty-first century. Curr Cardiol Rep. 2016 Oct;18(10):96.","journal-title":"Curr Cardiol Rep"},{"issue":"1","key":"key20210310134523_B12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/hrt.2004.034744","article-title":"Pathogenesis of acute rheumatic fever and rheumatic heart disease: Evasive after half a century of clinical, epidemiological, and laboratory investigation","volume":"91","author":"Kaplan","year":"2005","unstructured":"12. Kaplan EL. Pathogenesis of acute rheumatic fever and rheumatic heart disease: Evasive after half a century of clinical, epidemiological, and laboratory investigation. Heart. 2005 Jan;91(1):3-4.","journal-title":"Heart"},{"issue":"2","key":"key20210310134523_B13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/B978-0-12-385855-9.00002-3","article-title":"Rheumatic heart disease: Mediation by complex immune events","volume":"53","author":"Guilherme","year":"2011","unstructured":"13. Guilherme L, Kohler KF, Kalil J. Rheumatic heart disease: Mediation by complex immune events. Adv Clin Chem. 2011;53(2):31-50","journal-title":"Adv Clin Chem"},{"key":"key20210310134523_B14","doi-asserted-by":"crossref","first-page":"15084","DOI":"10.1038\/nrdp.2015.84","article-title":"Acute rheumatic fever and rheumatic heart disease","volume":"2","author":"Carapetis","year":"2016","unstructured":"14. Carapetis JR, Beaton A, Cunningham MW, Guilherme L, Karthikeyan G, Mayosi BM, et al. Acute rheumatic fever and rheumatic heart disease. Nat Rev Dis Primers. 2016;2:15084","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"key20210310134523_B15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10875-009-9332-6","article-title":"Rheumatic fever and rheumatic heart disease: Cellular mechanisms leading autoimmune reactivity and disease","volume":"30","author":"Guilherme","year":"2010","unstructured":"15. Guilherme L, Kalil J. Rheumatic fever and rheumatic heart disease: Cellular mechanisms leading autoimmune reactivity and disease. J Clin Immunol. 2010 Jan;30(1):17-23.","journal-title":"J Clin Immunol"},{"key":"key20210310134523_B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/abc.20180007","article-title":"Atualiza\u00e7\u00e3o das diretrizes brasileiras de valvopatias: Abordagem das les\u00f5es anatomicamente importantes","volume":"109","author":"Tarasoutchi","year":"2017","unstructured":"16. Tarasoutchi F, Montera MW, Ramos AIO, Sampaio RO, Rosa VEE, Accorsi TA, et al. Atualiza\u00e7\u00e3o das diretrizes brasileiras de valvopatias: Abordagem das les\u00f5es anatomicamente importantes. Arq Bras Cardiol. 2017;109(6 suppl 2):1-34.","journal-title":"Arq Bras Cardiol"},{"issue":"22","key":"key20210310134523_B17","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1016\/j.jacc.2014.02.537","article-title":"2014 aha\/acc guideline for the management of patients with valvular heart disease","volume":"63","author":"Nishimura","year":"2014","unstructured":"17. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA, et al. 2014 aha\/acc guideline for the management of patients with valvular heart disease. J Am Coll Cardiol. 2014 Jun 10;63(22):2438-88.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"key20210310134523_B18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the american society of echocardiography and the european association of cardiovascular imaging","volume":"16","author":"Lang","year":"2015","unstructured":"18. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the american society of echocardiography and the european association of cardiovascular imaging. Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):233-70.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"3","key":"key20210310134523_B19","article-title":"Clinical significance of markers of collagen metabolism in rheumatic mitral valve disease","volume":"9","author":"Sen","year":"2014","unstructured":"19. Sen U, Banerjee T, Mukherjee S, Ghosh S, Biswas M, Dutta S, et al. Clinical significance of markers of collagen metabolism in rheumatic mitral valve disease. PLoS One. 2014 Mar 6;9(3):e90527.","journal-title":"PLoS One"},{"issue":"9","key":"key20210310134523_B20","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.4049\/jimmunol.176.9.5662","article-title":"Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease","volume":"176","author":"Fae","year":"2006","unstructured":"20. Fae KC, Silva DD, Oshiro SE, Tanaka AC, Pomerantzeff PM, Douay C, et al. Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease. J Immunol. 2006 May 1;176(9):5662-70.","journal-title":"J Immunol"},{"issue":"3","key":"key20210310134523_B21","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1128\/CMR.13.3.470","article-title":"Pathogenesis of group A streptococcal infections","volume":"13","author":"Cunningham","year":"2000","unstructured":"21. Cunningham MW. Pathogenesis of group A streptococcal infections. Clin Microbiol Rev. 2000 Jul;13(3):470-511.","journal-title":"Clin Microbiol Rev"},{"issue":"7","key":"key20210310134523_B22","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1086\/656214","article-title":"Priming the immune system for heart disease: A perspective on group a streptococci","volume":"202","author":"Ellis","year":"2010","unstructured":"22. Ellis NM, Kurahara DK, Vohra H, Mascaro-Blanco A, Erdem G, Adderson EE, et al. Priming the immune system for heart disease: A perspective on group a streptococci. J Infect Dis. 2010 Oct 1;202(7):1059-67.","journal-title":"J Infect Dis"},{"issue":"3","key":"key20210310134523_B23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1086\/318076","article-title":"Pathogenic Mechanisms in Rheumatic Carditis: Focus on Valvular Endothelium","volume":"183","author":"Roberts","year":"2001","unstructured":"23. Roberts S, Kosanke S, Terrence Dunn S, Jankelow D, Duran CM, Cunningham MW. Pathogenic Mechanisms in Rheumatic Carditis: Focus on Valvular Endothelium. J Infect Dis. 2001 Feb 1;183(3):507-11.","journal-title":"J Infect Dis"},{"key":"key20210310134523_B24","first-page":"79","article-title":"Distinct mitral valve proteomic profiles in rheumatic heart disease and myxomatous degeneration","volume":"8","author":"Martins","year":"2014","unstructured":"24. Martins C, Santos KS, Ferreira FM, Teixeira PC, Pomerantzeff PM, Brand\u00e3o CM, et al. Distinct mitral valve proteomic profiles in rheumatic heart disease and myxomatous degeneration. Clin Med Insights Cardiol. 2014 Aug 27;8:79-86.","journal-title":"Clin Med Insights Cardiol"},{"issue":"1","key":"key20210310134523_B25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3346\/jkms.2008.23.1.41","article-title":"Overexpression of transforming growth factor-\u03b21 in the valvular fibrosis of chronic rheumatic heart disease","volume":"23","author":"Kim","year":"2008","unstructured":"25. Kim L, Kim DK, Yang WI, Shin DH, Jung IM, Park HK, et al. Overexpression of transforming growth factor-\u03b21 in the valvular fibrosis of chronic rheumatic heart disease. J Korean Med Sci. 2008 Feb;23(1):41-8.","journal-title":"J Korean Med Sci"},{"issue":"12","key":"key20210310134523_B26","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrcardio.2015.161","article-title":"Mitral valve disease\u2014morphology and mechanisms","volume":"12","author":"Levine","year":"2015","unstructured":"26. Levine RA, Hag\u00e9ge AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, et al. Mitral valve disease\u2014morphology and mechanisms. Nat Rev Cardiol. 2015 Dec;12(12):689-710.","journal-title":"Nat Rev Cardiol"},{"key":"key20210310134523_B27","first-page":"1472","volume-title":"Bogliolo: Patologia","author":"Brasileiro","year":"2006","unstructured":"27. Brasileiro, Filho G: Bogliolo: Patologia. 7 ed. Rio de Janeiro: Guanabara Koogan; 2006. 1472 p.","edition":"7 ed."},{"issue":"24","key":"key20210310134523_B28","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1161\/CIRCULATIONAHA.104.473165","article-title":"Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation","volume":"111","author":"Rajamannan","year":"2005","unstructured":"28. Rajamannan NM. Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation. Circulation. 2005 Jun 21;111(24):3296-301.","journal-title":"Circulation"},{"key":"key20210310134523_B29","volume-title":"Rheumatic fever and rheumatic heart disease: report of a WHO expert consultation on rheumatic fever and rheumatic heart disease","author":"World Health Organization (WHO)","year":"2001","unstructured":"29. World Health Organization (WHO). Rheumatic fever and rheumatic heart disease: report of a WHO expert consultation on rheumatic fever and rheumatic heart disease. Geneva;29 Oct-01- Nov 2001. (WHO Technical Report Series, 923)"},{"key":"key20210310134523_B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0066-782X2011001600001","article-title":"Sociedade Brasileira de Cardiologia. I Diretriz Latino Americana para o Diagn\u00f3stico e Tratamento da Cardiopatia Chag\u00e1sica","volume":"97","author":"Andrade","year":"2011","unstructured":"30. Andrade JP, Marin-Neto JA, Paola AA, Vilas-Boas F, Oliveira GM, Bacal F, ,et al. Sociedade Brasileira de Cardiologia. I Diretriz Latino Americana para o Diagn\u00f3stico e Tratamento da Cardiopatia Chag\u00e1sica. Arq Bras Cardiol. 2011; 97(2 supl.3): 1-48.","journal-title":"Arq Bras Cardiol"}],"container-title":["Arquivos Brasileiros de Cardiologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/abccardiol.org\/article\/caracterizacao-histologica-das-lesoes-da-valva-mitral-de-pacientes-com-cardiopatia-reumatica\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T13:03:57Z","timestamp":1747400637000},"score":1,"resource":{"primary":{"URL":"http:\/\/abccardiol.org\/article\/caracterizacao-histologica-das-lesoes-da-valva-mitral-de-pacientes-com-cardiopatia-reumatica\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,3]]}},"alternative-id":["10.36660\/abc.20200154"],"URL":"https:\/\/doi.org\/10.36660\/abc.20200154","relation":{},"ISSN":["0066-782X","1678-4170"],"issn-type":[{"value":"0066-782X","type":"print"},{"value":"1678-4170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}