{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:15:36Z","timestamp":1782976536640,"version":"3.54.5"},"reference-count":30,"publisher":"Sociedade Brasileira de Cardiologia","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.36660\/abc.20200381","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T19:18:18Z","timestamp":1608319098000},"page":"1094-1101","source":"Crossref","is-referenced-by-count":14,"title":["Estudo Comparativo da Doen\u00e7a Coronariana Microvascular Causada por Doen\u00e7a de Chagas e por Outras Etiologias"],"prefix":"10.36660","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5935-7229","authenticated-orcid":false,"given":"Felipe Araujo","family":"Campos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-6197","authenticated-orcid":false,"given":"Mariana L.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Turin","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael B.","family":"Pav\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Filho","given":"Moyses O.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor M.","family":"Lago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7863-7912","authenticated-orcid":false,"given":"Andr\u00e9 V.","family":"Badran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5822-3632","authenticated-orcid":false,"given":"Jo\u00e3o R. A.","family":"Chierice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1090-8165","authenticated-orcid":false,"given":"Andr\u00e9","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Neto","given":"Jos\u00e9 Antonio","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22636","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"key20201218141811_B1","author":"WHO","year":"2015","unstructured":". WHO. Investing to overcome the global impact of neglected tropical diseases: third WHO report on neglected diseases 2015. Geneva, Switzerland: World Health Organization; 2015. 191 p.","journal-title":"Investing to overcome the global impact of neglected tropical diseases: third WHO report on neglected diseases 2015"},{"issue":"11","key":"key20201218141811_B2","first-page":"1211","article-title":"Update on Chagas heart disease on the first centenary of its discovery","volume":"62","author":"Marin","year":"2009","unstructured":". Marin-Neto JA, Rassi A, Jr. Update on Chagas heart disease on the first centenary of its discovery. Revista espanola de cardiologia. 2009 Nov;62(11):1211-6.","journal-title":"Revista espanola de cardiologia"},{"issue":"9723","key":"key20201218141811_B3","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","unstructured":". Rassi A, Jr., Rassi A, Marin-Neto JA. Chagas disease. Lancet. 2010;375(9723):1388-402.","journal-title":"Lancet"},{"issue":"12","key":"key20201218141811_B4","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1161\/CIR.0000000000000599","article-title":"Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association","volume":"138","author":"Nunes","year":"2018","unstructured":". Nunes MCP, Beaton A, Acquatella H, Bern C, Bolger AF, Echeverria LE, Marin-Neto JA. Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association. Circulation. 2018;138(12):e169-e209.","journal-title":"Circulation"},{"issue":"9","key":"key20201218141811_B5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.106.624296","article-title":"Pathogenesis of chronic Chagas cardiomyopathy","volume":"115","author":"Marin","year":"2007","unstructured":". Marin-Neto JA, Cunha-Neto E, Sim\u00f5es MV, Maciel BC. Pathogenesis of chronic Chagas cardiomyopathy. Circulation 2007;115(9):1109-23.","journal-title":"Circulation"},{"key":"key20201218141811_B6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000674","article-title":"Coronary microvascular disease in chronic Chagas cardiomyopathy Including an overview on history, pathology, and other proposed pathogenic mechanisms","volume":"4","author":"Rossi","year":"2010","unstructured":". Rossi MA, Tanowitz HB, Malvestio LM, Celes MR, Campos EC, Blefari V,  et al. Coronary microvascular disease in chronic Chagas cardiomyopathy Including an overview on history, pathology, and other proposed pathogenic mechanisms. PLoS Negl Trop Dis 2010; 4:e674.","journal-title":"PLoS Negl Trop Dis"},{"key":"key20201218141811_B7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0002-8703(90)90191-Y","article-title":"Microvascular changes as a cause of chronic cardiomyopathyin Chagas\u2019disease","volume":"120","author":"Rossi","year":"1990","unstructured":". Rossi MA. Microvascular changes as a cause of chronic cardiomyopathyin Chagas\u2019disease. Am Heart J 1990; 120:233-236.","journal-title":"Am Heart J"},{"key":"key20201218141811_B8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/hrt.82.3.279","article-title":"Different microcirculatory and interstitial matrix patterns in idiopathic dilated cardiomyopathy and Chagas\u2019disease: a three dimensional confocalmicroscopy study","volume":"82","author":"Higuchi","year":"1999","unstructured":". Higuchi ML, Fukasawa S, De Brito T, Parzianello LC, Bellotti G, RamiresJA. Different microcirculatory and interstitial matrix patterns in idiopathic dilated cardiomyopathy and Chagas\u2019disease: a three dimensional confocalmicroscopy study. Heart 1999; 82:279-285.","journal-title":"Heart"},{"issue":"5","key":"key20201218141811_B9","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1590\/0037-8682-0028-2013","article-title":"Pathogenesis of chronic Chagas cardiomyopathy: the role of coronary microvascular derangements","volume":"46","author":"Marin","year":"2013","unstructured":". Marin-Neto JA, Simoes MV, Rassi Junior A. Pathogenesis of chronic Chagas cardiomyopathy: the role of coronary microvascular derangements. Rev Soc Bras Med Trop. 2013 Sep-Oct;46(5):536-41.","journal-title":"Rev Soc Bras Med Trop"},{"key":"key20201218141811_B10","first-page":"823","volume-title":"Evidence-Based Cardiology","author":"Marin","year":"2010","unstructured":". Marin-Neto JA, Rassi Jr A, Sim\u00f5es MV, Maciel BC, Schmidt A. Chagasheart disease. In: Yusuf S, Cairns JA, Camm AJ, Fallen EL, Gersh BJ. Evidence-Based Cardiology. 3rd edition. Chapter 51; 2010. p. 823-841.","edition":"3rd"},{"key":"key20201218141811_B11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1056\/NEJM199109123251103","article-title":"Chagas\u2019 heart disease in the United States","volume":"325","author":"Hagar","year":"1991","unstructured":". Hagar JM, Rahintoola SH. Chagas\u2019 heart disease in the United States.N Engl J Med 1991; 325:763-768","journal-title":"N Engl J Med"},{"key":"key20201218141811_B12","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/0002-9149(92)90505-S","article-title":"Myocardial perfusion abnormalities in chronic Chagas\u2019disease as detected by thallium-201 scintigraphy","volume":"69","author":"Marin","year":"1992","unstructured":". Marin-Neto JA, Marzullo P, Marcassa C, Gallo-Junior L, MacielBC, Bellina CR,  et al. Myocardial perfusion abnormalities in chronic Chagas\u2019disease as detected by thallium-201 scintigraphy. Am J Cardiol 1992; 69:780-784.","journal-title":"Am J Cardiol"},{"key":"key20201218141811_B13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1590\/S0066-782X2010005000064","article-title":"Scintigraphy of the detectionof myocardial damage in the indeterminate form of Chagas disease","volume":"95","author":"Abuhid","year":"2010","unstructured":". Abuhid IM, Pedroso ERP, Rezende NA. Scintigraphy of the detectionof myocardial damage in the indeterminate form of Chagas disease. Arq Bras Cardiol 2010; 95:30-34.","journal-title":"Arq Bras Cardiol"},{"key":"key20201218141811_B14","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002786","article-title":"Histopathological correlates of global and segmental left ventricular systolic dysfunction in experimental chronic chagas cardiomyopathy","volume":"5","author":"Oliveira","year":"2016","unstructured":". Oliveira LFL, Romano MMD, Carvalho EEV, Mejia J, Salgado HC, Fazan R Jr,  et al. Histopathological correlates of global and segmental left ventricular systolic dysfunction in experimental chronic chagas cardiomyopathy. J Am Heart Assoc 2016;5:e002786.","journal-title":"J Am Heart Assoc"},{"key":"key20201218141811_B15","article-title":"Prolonged dipyridamole administration reduces myocardial perfusion defects in experimental chronic Chagas cardiomyopathy","author":"Tanaka","year":"2018","unstructured":". Tanaka, DM, Oliveira LFL, Marin-Neto JA, Romano MMD, Carvalho, ELV, Barros, ACL. Prolonged dipyridamole administration reduces myocardial perfusion defects in experimental chronic Chagas cardiomyopathy. J Nucl Cardiol 2018.","journal-title":"J Nucl Cardiol"},{"key":"key20201218141811_B16","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1056\/NEJMra061889","article-title":"Coronary microvascular dysfunction","volume":"356","author":"Camici","year":"2007","unstructured":". Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med 2007; 356: 830-40.","journal-title":"N Engl J Med"},{"key":"key20201218141811_B17","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/eurheartj\/eht513","article-title":"Coronary microvascular dysfunction: an update","volume":"35","author":"Crea","year":"2014","unstructured":". Crea F, Camici PG, Merz CNB. Coronary microvascular dysfunction: an update. European Heart J 2014; 35: 1101-11.","journal-title":"European Heart J"},{"key":"key20201218141811_B18","first-page":"284","article-title":"Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need","volume":"104","author":"Ford","year":"2018","unstructured":". Ford T, Corcoran D, Berry C. Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need. Heart 2018; 104: 284-92.","journal-title":"Heart"},{"key":"key20201218141811_B19","first-page":"207","volume-title":"Manual de Cardiologia","author":"Marin-Neto","year":"2000","unstructured":". Marin-Neto J.A. & Ayres-Neto, E.M. Cinecoronariografia: quando n\u00e3o \u00e9 e quando \u00e9 preciso indicar?. In: Manual de Cardiologia. Timerman, A. & C\u00e9sar, L.A.M. (eds.). Editora Atheneu,S\u00e3o Paulo,p.207-211,590 p.,2000. ISBN 85-7379-254-X."},{"issue":"5","key":"key20201218141811_B20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1590\/S0066-782X2005000500005","article-title":"Potencia\u00e7\u00e3o p\u00f3s-extrassist\u00f3lica na cardiopatia chag\u00e1sica cr\u00f4nica. Estudo com ventriculografia de contraste radiol\u00f3gico","volume":"84","author":"Brand\u00e3o","year":"2005","unstructured":". Brand\u00e3o, JMM.; Miziara, A; Figueiredo, GL.; Lima-Filho, MO; Ayres-Neto, EM. & Marin-Neto, JA. Potencia\u00e7\u00e3o p\u00f3s-extrassist\u00f3lica na cardiopatia chag\u00e1sica cr\u00f4nica. Estudo com ventriculografia de contraste radiol\u00f3gico. Arquivos Brasileiros de Cardiologia 84(5): 376-380, 2005.","journal-title":"Arquivos Brasileiros de Cardiologia"},{"issue":"2","key":"key20201218141811_B21","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.echo.2018.09.006","article-title":"Effects of Trypanocidal Treatment on Echocardiographic Parameters in Chagas Cardiomyopathy and Prognostic Value of Wall Motion Score Index: A BENEFIT Trial Echocardiographic Substudy","volume":"32","author":"Schmidt","year":"2019","unstructured":". Schmidt A, Dias Romano MM, Marin-Neto JA, Rao-Melacini P, Rassi A, Jr., Mattos A, et al. Effects of Trypanocidal Treatment on Echocardiographic Parameters in Chagas Cardiomyopathy and Prognostic Value of Wall Motion Score Index: A BENEFIT Trial Echocardiographic Substudy. J Am Soc Echocardiogr. 2019;32(2):286-95 e3","journal-title":"J Am Soc Echocardiogr"},{"issue":"2","key":"key20201218141811_B22","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jcmg.2008.09.012","article-title":"Changes in myocardial perfusion correlate with deterioration of left ventricular systolic function in chronic Chagas\u2019 cardiomyopathy","volume":"2","author":"Hiss","year":"2009","unstructured":". Hiss FC, Lascala TF, Maciel BC, Marin-Neto JA, Simoes MV. Changes in myocardial perfusion correlate with deterioration of left ventricular systolic function in chronic Chagas\u2019 cardiomyopathy. JACC Cardiovascular imaging. 2009 Feb;2(2):164-72. PubMed PMID: 19356551. Epub 2009\/04\/10. eng","journal-title":"JACC Cardiovascular imaging"},{"issue":"1","key":"key20201218141811_B23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12350-016-0556-6","article-title":"The severity of ventricular arrhythmia correlates with the extent of myocardial sympathetic denervation, but not with myocardial fibrosis extent in chronic Chagas cardiomyopathy : Chagas disease, denervation and arrhythmia","volume":"25","author":"Gadioli","year":"2018","unstructured":". Gadioli LP, Miranda CH, Pintya AO, de Figueiredo AB, Schmidt A, Maciel BC,  et al. The severity of ventricular arrhythmia correlates with the extent of myocardial sympathetic denervation, but not with myocardial fibrosis extent in chronic Chagas cardiomyopathy : Chagas disease, denervation and arrhythmia. J Nucl Cardiol. 2018 Feb;25(1):75-83. PubMed PMID: 27381340","journal-title":"J Nucl Cardiol"},{"key":"key20201218141811_B24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/0037-8682-0505-2016","article-title":"2 nd Brazilian Consensus on Chagas Disease, 2015","volume":"49","author":"Dias","year":"2016","unstructured":". Dias JC, Ramos AN, Jr., Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. 2 nd Brazilian Consensus on Chagas Disease, 2015. Rev Soc Bras Med Trop. 2016;49Suppl 1(Suppl 1):3-60.","journal-title":"Rev Soc Bras Med Trop"},{"key":"key20201218141811_B25","doi-asserted-by":"crossref","DOI":"10.31160\/JOTCI202028A20190034","article-title":"Cardiac catheterization with normal coronary arteries: prevalence rate and analysis of predictor variables","author":"Sant\u2019 Anna","year":"2020","unstructured":". Sant\u2019 Anna LB, Sant\u2019 Anna FM, Couceiro, SLM, P\u00e9rez MA. Cardiac catheterization with normal coronary arteries: prevalence rate and analysis of predictor variables. J Transcath Interv 2020;","journal-title":"J Transcath Interv"},{"issue":"10","key":"key20201218141811_B26","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1056\/NEJMoa0907272","article-title":"Low Diagnostic Yield of Elective Coronary Angiography","volume":"362","author":"Patel","year":"2010","unstructured":". Manesh R. Patel, M.D., Eric D. Peterson, M.D., M.P.H., David Dai, M.S., J. Matthew Brennan,M.D., Rita F. Redberg, M.D., H. Vernon Anderson, M.D., Ralph G. Brindis, M.D., and Pamela S. Douglas, M.D. Low Diagnostic Yield of Elective Coronary Angiography. N Engl J Med. 2010 March 11; 362(10): 886\u2013895.","journal-title":"N Engl J Med"},{"key":"key20201218141811_B27","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1093\/eurheartj\/ehx721","article-title":"Coronary microvascular dysfunction and future risk of heart failure with preserved ejection fraction","volume":"39","author":"Taqueti","year":"2018","unstructured":". Viviany R. Taqueti1 *, Scott D. Solomon1, Amil M. Shah1, Akshay S. Desai2, John D. Groarke2, Michael T. Osborne3, Jon Hainer1, Courtney F. Bibbo1, Sharmila Dorbala1, Ron Blankstein1, and Marcelo F. Di Carli1. Coronary microvascular dysfunction and future risk of heart failure with preserved ejection fraction. European Heart Journal (2018) 39, 840\u2013849","journal-title":"European Heart Journal"},{"key":"key20201218141811_B28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijcard.2017.08.068","article-title":"International standardization of diagnostic criteria formicrovascular angina\u2606","volume":"250","author":"Ong","year":"2018","unstructured":". Peter Ong a,\u204e,1, Paolo G. Camici b,1, John F. Beltrame c, Filippo Crea d, Hiroaki Shimokawa e, Udo Sechtema,Juan Carlos Kaski f,2, C. Noel BaireyMerz g, International standardization of diagnostic criteria formicrovascular angina\u2606. International Journal of Cardiology 250 (2018) 16\u201320","journal-title":"International Journal of Cardiology"},{"key":"key20201218141811_B29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/echo.12364","article-title":"Impaired Coronary Flow Reserve in Patients with Indeterminate Form of Chagas\u2019 Disease","volume":"31","author":"Rabelo","year":"2014","unstructured":". Daniel R. Rabelo, M.D.,* Manoel Otavio da Costa Rocha, M.D., Ph.D.,* Marcio V. L. de Barros, M.D., Ph.D.,*Jose Luiz Padilha da Silva, M.S.,\u2020 Timothy C. Tan, M.D., Ph.D.,\u2021 and Maria C. P. Nunes, M.D., Ph.D.* Impaired Coronary Flow Reserve in Patients with Indeterminate Form of Chagas\u2019 Disease. Echocardiography 2014;31:67\u2013 73).","journal-title":"Echocardiography"},{"issue":"3","key":"key20201218141811_B30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.23736\/S1824-4785.17.02930-2","article-title":"Physical training reduces myocardial perfusion disturbances and improves quality of life in patients with primary microvascular angina","volume":"63","author":"Carvalho","year":"2019","unstructured":". Carvalho EE, Cresc\u00eancio JC, Santi GL, Oliveira LF, Schwartzmann PV, Gallo-Junior L, Marin-Neto JA, Sim\u00f5es MV.Physical training reduces myocardial perfusion disturbances and improves quality of life in patients with primary microvascular angina. Q J Nucl Med Mol Imaging. 2019 Sep;63(3):302-310. doi: 10.23736\/S1824-4785.17.02930-2. Epub 2017 Mar 16.","journal-title":"Q J Nucl Med Mol Imaging"}],"container-title":["Arquivos Brasileiros de Cardiologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/abccardiol.org\/article\/chagas-cardiomyopathy-as-the-etiology-of-suspected-coronary-microvascular-disease-a-comparison-study-with-suspected-coronary-microvascular-disease-of-other-etiologies\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T13:03:06Z","timestamp":1747400586000},"score":1,"resource":{"primary":{"URL":"http:\/\/abccardiol.org\/article\/chagas-cardiomyopathy-as-the-etiology-of-suspected-coronary-microvascular-disease-a-comparison-study-with-suspected-coronary-microvascular-disease-of-other-etiologies\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,12,14]]},"published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.36660\/abc.20200381"],"URL":"https:\/\/doi.org\/10.36660\/abc.20200381","relation":{},"ISSN":["0066-782X","1678-4170"],"issn-type":[{"value":"0066-782X","type":"print"},{"value":"1678-4170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}