{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:39Z","timestamp":1772253159173,"version":"3.50.1"},"reference-count":26,"publisher":"Sociedade Brasileira de Cardiologia","issue":"6","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento: Existem poucos estudos retrospectivos e prospectivos sobre cardiodesfibrilador implant\u00e1vel (CDI) na preven\u00e7\u00e3o prim\u00e1ria e secund\u00e1ria de morte s\u00fabita na cardiopatia chag\u00e1sica cr\u00f4nica (CCC).  Objetivos: Descrever a evolu\u00e7\u00e3o a longo prazo dos portadores de CCC com CDI e identificar e analisar os preditores de mortalidade e de terapia apropriada do dispositivo nessa popula\u00e7\u00e3o.  M\u00e9todos: Trata-se de um estudo prospectivo hist\u00f3rico com 117 pacientes portadores de CDI e CCC. Dispositivos foram implantados de janeiro de 2003 a dezembro de 2021. Fatores preditores de terapias apropriadas e mortalidade a longo prazo foram identificados e analisados. O n\u00edvel de signific\u00e2ncia estat\u00edstica \u00e9 de p &lt; 0,05.  Resultados: Pacientes (n = 117) tiveram mediana de seguimento de 61 meses (25 a 121 meses), sendo o g\u00eanero masculino (74%) predominante e a mediana de idade de 55 anos (48 a 64 anos). Houve 43,6% de choques apropriados, 26,5% de estimula\u00e7\u00e3o card\u00edaca antitaquicardia (ATP) e 51% de terapias apropriadas. Durante o seguimento, 46 pacientes (39,7%) foram a \u00f3bito. A mortalidade foi de 6,2% pessoas-ano (intervalo de confian\u00e7a [IC] 95%: 4,6 a 8,3), com 2 mortes s\u00fabitas durante o seguimento. A preven\u00e7\u00e3o secund\u00e1ria (hazard ratio [HR] 2.1; IC 95%: 1,1 a 4,3; p = 0,029) e a fra\u00e7\u00e3o de eje\u00e7\u00e3o menor que 30% (HR 1.8; IC 95%: 1,1 a 3,1; p &lt; 0,05) foram preditores de terapias apropriadas. Escore de Rassi intermedi\u00e1rio apresentou uma forte associa\u00e7\u00e3o com ocorr\u00eancia de ATP isoladamente (p = 0,015). A classe funcional IV (p = 0,007), fra\u00e7\u00e3o de eje\u00e7\u00e3o do ventr\u00edculo esquerdo &lt; 30 (p = 0,010) e a idade maior que 75 anos (p = 0,042) foram preditores de mortalidade total.  Conclus\u00e3o: Os desfibriladores na CCC apresentaram elevada incid\u00eancia de acionamento apropriado especialmente naqueles pacientes de preven\u00e7\u00e3o secund\u00e1ria, fra\u00e7\u00e3o de eje\u00e7\u00e3o do ventr\u00edculo esquerdo baixa e escore de Rassi intermedi\u00e1rio. Os pacientes com insufici\u00eancia card\u00edaca congestiva, classe funcional avan\u00e7ada e idade maior que 75 anos apresentaram elevada mortalidade.<\/jats:p>","DOI":"10.36660\/abc.20230337","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T13:41:51Z","timestamp":1724938911000},"source":"Crossref","is-referenced-by-count":1,"title":["Preditores de Terapias Apropriadas e \u00d3bito em Pacientes com Cardiodesfibrilador Implant\u00e1vel e Cardiopatia Chag\u00e1sica Cr\u00f4nica"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3505-8811","authenticated-orcid":false,"given":"Francisca Tatiana Moreira","family":"Pereira","sequence":"first","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Arrais","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davi Sales Pereira","family":"Gondim","sequence":"additional","affiliation":[{"name":"Universidade de Fortaleza,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Livia Freitas de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Tulane University School of Public Health and Tropical Medicine,  EUA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto da Justa","family":"Pires Neto","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil; Hospital S\u00e3o Jos\u00e9 de Doen\u00e7as Infecciosas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"6","key":"ref1","article-title":"SBC Guideline on the Diagnosis and Treatment of Patients with Cardiomyopathy of Chagas Disease - 2023","volume":"120","author":"Marin-Neto JA","year":"2023","journal-title":"Arq Bras Cardiol"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1590\/S0066-782X2001000100008","article-title":"Sudden Death in Chagas\u2019 Disease","volume":"76","author":"Rassi Jr A","year":"2001","journal-title":"Arq Bras Cardiol"},{"issue":"22","key":"ref3","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1056\/NEJM199711273372202","article-title":"A Comparison of Antiarrhythmic-drug Therapy with Implantable Defibrillators in Patients Resuscitated from Near-fatal Ventricular Arrhythmias","volume":"337","year":"1997","journal-title":"N Engl J Med"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1161\/01.CIR.102.7.748","article-title":"Randomized Comparison of Antiarrhythmic Drug Therapy with Implantable Defibrillators in Patients Resuscitated from Cardiac Arrest: The Cardiac Arrest Study Hamburg (CASH)","volume":"102","author":"Kuck KH","year":"2000","journal-title":"Circulation"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1161\/01.CIR.101.11.1297","article-title":"Canadian Implantable Defibrillator Study (CIDS): A Randomized Trial of the Implantable Cardioverter Defibrillator Against Amiodarone","volume":"101","author":"Connolly SJ","year":"2000","journal-title":"Circulation"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jacc.2020.05.061","article-title":"Long-term Outcomes of Implantable Cardioverter-Defibrillator Therapy in the SCD-HeFT","volume":"76","author":"Poole JE","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"26","key":"ref7","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1056\/NEJM199612263352601","article-title":"Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia. 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Electrophysiol"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa053241","article-title":"Development and Validation of a Risk Score for Predicting Death in Chagas\u2019 Heart Disease","volume":"355","author":"Rassi Jr A","year":"2006","journal-title":"N Engl J Med"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1159\/000177142","article-title":"Predictors of Sudden Cardiac Death for Patients with Chagas\u2019 Disease: A Hospital-derived Cohort Study","volume":"87","author":"Bestetti RB","year":"1996","journal-title":"Cardiology"},{"issue":"6","key":"ref18","first-page":"367","article-title":"Empiric Therapy with Amiodarone in Patients with Chronic Chagas Cardiomyopathy and Sustained Ventricular Tachycardia","volume":"54","author":"Scanavacca MI","year":"1990","journal-title":"Arq Bras 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