{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:19Z","timestamp":1772253139544,"version":"3.50.1"},"reference-count":26,"publisher":"Sociedade Brasileira de Cardiologia","issue":"6","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento: A cardiomiopatia associada \u00e0 lipodistrofia parcial (LP) ainda n\u00e3o foi bem descrita.  Objetivo: Caracterizar a morfologia e a fun\u00e7\u00e3o card\u00edaca na LP.  M\u00e9todos: Pacientes com LP e controles foram avaliados prospectivamente por ecocardiografia transtor\u00e1cica e ecocardiografia por speckle-tracking (Strain Longitudinal Global, SLG). A rela\u00e7\u00e3o entre as vari\u00e1veis ecocardiogr\u00e1ficas e o diagn\u00f3stico de LP foi testada com modelos de regress\u00e3o, considerando o efeito da press\u00e3o arterial sist\u00f3lica (PAS). Adotou-se um n\u00edvel de signific\u00e2ncia de 5%.  Resultados: Vinte e nove pacientes com LP foram comparados com 17 controles. Eles n\u00e3o se diferiram quanto \u00e0 idade (p=0,94), sexo ou \u00edndice de massa corporal (p= 0,05). Os pacientes com LP apresentaram PAS estatisticamente mais alta (p=0,02) em compara\u00e7\u00e3o aos controles. Ainda, os pacientes com LP apresentaram maior dimens\u00e3o do \u00e1trio (37,3 \u00b1 4,4 vs. 32,1 \u00b1 4,3 mm, p= 0,001) e maior volume atrial (30,2 \u00b1 7,2 vs. 24,9 \u00b1 9,0 mL\/m2, p=0,02), massa do Ventr\u00edculo Esquerdo (VE) (79,3 \u00b1 17,4 vs. 67,1 \u00b1 19,4; p=0,02), e par\u00e2metros sist\u00f3licos reduzidos do VE (E\u2019 lateral, p= 0,001) (E\u2019 septal, p= 0,001), (raz\u00e3o E\/E\u2019, p= 0,02). A fra\u00e7\u00e3o de eje\u00e7\u00e3o do VE (64,7 \u00b1 4,6 vs. 62,2 \u00b1 4,4 %, p = 0,08) e o SLG n\u00e3o foram estatisticamente diferentes entre os grupos (-17,1\u00b12,7 vs-18.0 \u00b1 2,0%, p= 0,25). Observou-se uma rea\u00e7\u00e3o positiva do \u00e1trio esquerdo (\u03b2 5,6; p&lt;0,001), espessura da parede posterior (\u03b2 1,3; p=0,011), E\u2019 lateral (\u03b2 -3,5; p=0,002) e E\u2019 septal (\u03b2 -3,2; p&lt;0,001) com o diagn\u00f3stico de LP, mesmo ap\u00f3s o ajuste para a PAS.  Conclus\u00e3o: Os pacientes com LP apresentam hipertrofia do VE, aumento do \u00e1trio esquerdo, e disfun\u00e7\u00e3o diast\u00f3lica do VE apesar de fra\u00e7\u00e3o de eje\u00e7\u00e3o do VE e SLG preservados. Os par\u00e2metros ecocardiogr\u00e1ficos est\u00e3o relacionados com o diagn\u00f3stico de LP, independentemente da PAS.<\/jats:p>","DOI":"10.36660\/abc.20230442","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T11:56:28Z","timestamp":1720180588000},"source":"Crossref","is-referenced-by-count":0,"title":["Altera\u00e7\u00f5es Ecocardiogr\u00e1ficas da Geometria e da Fun\u00e7\u00e3o Card\u00edaca em Pacientes com Lipodistrofia Familiar Parcial"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8742-3764","authenticated-orcid":false,"given":"Minna Moreira Dias","family":"Romano","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Tim\u00f3teo","family":"Sapalo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-3141","authenticated-orcid":false,"given":"Nat\u00e1lia Rossin","family":"Guidorizzi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4543-4684","authenticated-orcid":false,"given":"Henrique Turin","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3249-3455","authenticated-orcid":false,"given":"Paula Ananda Chacon","family":"In\u00eas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Candel\u00e1ria","family":"Kalil","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Foss","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Jos\u00e9 Albuquerque de","family":"Paula","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"104071","DOI":"10.1016\/j.lpm.2021.104071","article-title":"Familial Partial Lipodystrophy Syndromes","volume":"50","author":"Fern\u00e1ndez-Pombo A","year":"2021","journal-title":"Presse Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2147\/DMSO.S130810","article-title":"Estimating the Prevalence of Generalized and Partial Lipodystrophy: Findings and Challenges","volume":"10","author":"Chiquette E","year":"2017","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1006\/mgme.2000.3092","article-title":"Familial Partial Lipodystrophy: A Monogenic Form of the Insulin Resistance Syndrome","volume":"71","author":"Hegele RA","year":"2000","journal-title":"Mol Genet Metab"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1210\/jc.2016-1005","article-title":"Natural History of Congenital Generalized Lipodystrophy: A Nationwide Study From Turkey","volume":"101","author":"Akinci B","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jacc.2020.11.069","article-title":"Leptin in Leanness and Obesity: JACC State-of-the-Art Review","volume":"77","author":"Perakakis N","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1210\/jcem.87.5.8624","article-title":"Serum Adiponectin and Leptin Levels in Patients with Lipodystrophies","volume":"87","author":"Haque WA","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s12020-019-01862-8","article-title":"Long-term Effectiveness and Safety of Metreleptin in the Treatment of Patients with Partial Lipodystrophy","volume":"64","author":"Oral EA","year":"2019","journal-title":"Endocrine"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1210\/jc.2016-2466","article-title":"The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline","volume":"101","author":"Brown RJ","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"ref9","article-title":"Causes of Death in Patients with Berardinelli-Seip Congenital Generalized Lipodystrophy","volume":"13","author":"Lima JG","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.diabet.2018.09.006","article-title":"Cardiometabolic Assessment of Lamin A\/C Gene Mutation Carriers: A Phenotype-genotype Correlation","volume":"45","author":"Kwapich M","year":"2019","journal-title":"Diabetes Metab"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1161\/ATVBAHA.113.301933","article-title":"Lipodystrophy-linked LMNA p.R482W Mutation Induces Clinical Early Atherosclerosis and in Vitro Endothelial Dysfunction","volume":"33","author":"Bidault G","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00441777","article-title":"Echocardiographic Assessment of Cardiac Function and Morphology in Patients with Generalised Lipodystrophy","volume":"144","author":"Bj\u00f8rnstad PG","year":"1985","journal-title":"Eur J Pediatr"},{"issue":"2","key":"ref13","first-page":"305","article-title":"Cardiac Alterations in Patients with Familial Lipodystrophy","volume":"114","author":"Romano MMD","year":"2020","journal-title":"Arq Bras Cardiol"},{"issue":"1","key":"ref14","first-page":"109","article-title":"Cardiometabolic Abnormalities in Patients with Berardinelli-Seip Syndrome","volume":"94","author":"R\u00eago AG","year":"2010","journal-title":"Arq Bras Cardiol"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.amjcard.2013.05.036","article-title":"Cardiac Steatosis and Left Ventricular Hypertrophy in Patients with Generalized Lipodystrophy as Determined by Magnetic Resonance Spectroscopy and Imaging","volume":"112","author":"Nelson MD","year":"2013","journal-title":"Am J Cardiol"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.2337\/db16-0733","article-title":"The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model","volume":"66","author":"Joubert M","year":"2017","journal-title":"Diabetes"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/cvr\/cvx012","article-title":"Inflammation and Metabolic Cardiomyopathy","volume":"113","author":"Nishida K","year":"2017","journal-title":"Cardiovasc Res"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.echo.2010.02.015","article-title":"Assessment of Myocardial Mechanics Using Speckle Tracking Echocardiography: Fundamentals and Clinical Applications","volume":"23","author":"Geyer H","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.jcmg.2019.01.044","article-title":"2- and 3-Dimensional Myocardial Strain in Cardiac Health and Disease","volume":"12","author":"Voigt JU","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2147\/DMSO.S233667","article-title":"Early Left Ventricular Systolic Dysfunction Detected by Two-Dimensional Speckle-Tracking Echocardiography in Young Patients with Congenital Generalized Lipodystrophy","volume":"13","author":"Liberato CBR","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang RM","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.echo.2020.12.008","article-title":"Application of Guideline-Based Echocardiographic Assessment of Left Atrial Pressure to Heart Failure with Preserved Ejection Fraction","volume":"34","author":"Rethy L","year":"2021","journal-title":"J Am Soc Echocardiogr"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1590\/S0066-782X2000000900006","article-title":"Cardiac Involvement in Total Generalized Lipodystrophy (Berardinelli- Seip Syndrome)","volume":"75","author":"Vi\u00e9gas RF","year":"2000","journal-title":"Arq Bras Cardiol"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1034\/j.1399-0004.2002.610407.x","article-title":"Cardiomyopathy in Congenital Complete Lipodystrophy","volume":"61","author":"Bhayana 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