{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:03Z","timestamp":1772253183694,"version":"3.50.1"},"reference-count":23,"publisher":"Sociedade Brasileira de Cardiologia","issue":"6","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  \u00c9 desconhecido se a linfopenia \u00e9 fator de risco para a reativa\u00e7\u00e3o da doen\u00e7a de Chagas no transplante card\u00edaco (TxC), como recentemente descrito na reativa\u00e7\u00e3o de citomegalov\u00edrus em pacientes transplantados.  Objetivo  Avaliar se a linfopenia no perioperat\u00f3rio do TxC est\u00e1 relacionada \u00e0 parasitemia precoce pelo Trypanosoma cruzi.  M\u00e9todos  Amostra analisada (janeiro de 2014 a janeiro de 2023) em estudo observacional e retrospectivo. A parasitemia foi avaliada nos primeiros 3 meses ap\u00f3s o TxC por meio da rea\u00e7\u00e3o em cadeia da polimerase s\u00e9rica (PCR) e comparada com a contagem total de linf\u00f3citos no perioperat\u00f3rio do TxC por curvas ROC. Comparadas caracter\u00edsticas de base com a PCR Chagas por modelos de risco proporcionais de Cox independentes. N\u00edvel de signific\u00e2ncia adotado de 5%.  Resultados  Amostra (n = 35) apresentou idade m\u00e9dia de 52,5 \u00b1 8,1 anos e PCR Chagas positiva em 22 pacientes (62,8%). As m\u00e9dias dos menores valores de linf\u00f3citos nos primeiros 14 dias do TxC foram 398 \u00b1 189 e 755 \u00b1 303 c\u00e9lulas\/mm3 em pacientes com e sem parasitemia nos 3 meses ap\u00f3s o TxC, respectivamente (\u00e1rea sob a curva = 0,857; intervalo de confian\u00e7a de 95%: 0,996 a 0,718, sensibilidade e especificidade de 83,3% e 86,4%). Determinado valor de corte inferior a 550 linf\u00f3citos\/mm3 como fator de risco para presen\u00e7a de parasitemia. Pacientes com linf\u00f3citos &lt; 550 unidades\/mm3 nos primeiros 14 dias do p\u00f3s-TxC apresentaram PCR positiva em 80% dos casos. Para cada aumento de 100 linf\u00f3citos\/mm3, o risco de positividade da PCR \u00e9 reduzido em 26% (raz\u00e3o de riscos = 0,74; intervalo de confian\u00e7a de 95%: 0,59 a 0,93, p = 0,009).  Conclus\u00e3o  Houve associa\u00e7\u00e3o entre a linfopenia no perioperat\u00f3rio do TxC com a parasitemia precoce pelo T. cruzi detectada por PCR.<\/jats:p>","DOI":"10.36660\/abc.20230588","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T14:19:18Z","timestamp":1721917158000},"source":"Crossref","is-referenced-by-count":0,"title":["Contagem Absoluta de Linf\u00f3citos: um Preditor de PCR S\u00e9rica Positiva para o Trypanosoma cruzi em Pacientes com Chagas Submetidos ao Transplante Card\u00edaco"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-2683","authenticated-orcid":false,"given":"Pl\u00ednio Jos\u00e9 Whitaker","family":"Wolf","sequence":"first","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Aurelio","family":"Finger","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de 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