{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:17Z","timestamp":1772253137533,"version":"3.50.1"},"reference-count":37,"publisher":"Sociedade Brasileira de Cardiologia","issue":"7","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  A remodela\u00e7\u00e3o adversa dos vasos pulmonares eleva a press\u00e3o pulmonar e provoca hipertens\u00e3o arterial pulmonar (HAP). A HAP resulta em aumento da p\u00f3s-carga do ventr\u00edculo direito (VD), causando hipertrofia ventricular e consequente insufici\u00eancia card\u00edaca. N\u00e3o existe um tratamento espec\u00edfico para o remodelamento desadaptativo do VD secund\u00e1rio \u00e0 HAP.  Objetivos  Este estudo tem como objetivo explorar duas abordagens terap\u00eauticas, o suco de uva (SU) e os horm\u00f4nios tireoidianos (HT), no tratamento do estresse oxidativo induzido pela HAP e nas altera\u00e7\u00f5es funcionais card\u00edacas.  M\u00e9todos  Par\u00e2metros ecocardiogr\u00e1ficos relacionados \u00e0 resist\u00eancia dos vasos pulmonares (rela\u00e7\u00e3o TA\/TE), contratilidade do VD (ESPAT) e fun\u00e7\u00e3o diast\u00f3lica do VD (rela\u00e7\u00e3o dos picos E\/A) foram avaliados. Al\u00e9m disso, foram medidos ROS totais, peroxida\u00e7\u00e3o lip\u00eddica, enzimas antioxidantes, prote\u00ednas de manipula\u00e7\u00e3o de c\u00e1lcio, express\u00e3o de prote\u00ednas pr\u00f3-oxidantes e antioxidantes. Valores de p&lt;0,05 foram considerados estatisticamente significativos.  Resultados  Ambos os tratamentos, com SU e HT, demonstraram uma redu\u00e7\u00e3o na resist\u00eancia pulmonar (~22%), al\u00e9m de melhorias na ESPAT (inotropismo ~11%) e na rela\u00e7\u00e3o TA\/TE (~26%) (p&lt;0,05). N\u00e3o houve altera\u00e7\u00f5es entre os grupos na rela\u00e7\u00e3o do pico de E\/A. Embora ROS e TBARS n\u00e3o tenham sido estatisticamente significativos, os tratamentos com SU e HT diminu\u00edram os n\u00edveis de xantina oxidase (~49%) e normalizaram a express\u00e3o de HSP70 e prote\u00ednas de manipula\u00e7\u00e3o de c\u00e1lcio (p&lt;0,05). No entanto, apenas o tratamento com HT melhorou a fun\u00e7\u00e3o diast\u00f3lica (~50%) e aumentou o imunoconte\u00fado de NRF2 (~48%) (p&lt;0,05).  Conclus\u00f5es  At\u00e9 onde sabemos, este estudo \u00e9 pioneiro ao mostrar que o HT administrado em conjunto com o SU promoveu melhorias funcionais e bioqu\u00edmicas em um modelo de HAP. Al\u00e9m disso, nossos dados sugerem que os tratamentos com SU e HT se mostraram cardioprotetores, sejam combinados ou n\u00e3o, e exibiram seus benef\u00edcios ao modular o estresse oxidativo e as prote\u00ednas de manipula\u00e7\u00e3o do c\u00e1lcio.<\/jats:p>","DOI":"10.36660\/abc.20230602","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T15:53:43Z","timestamp":1721750023000},"source":"Crossref","is-referenced-by-count":0,"title":["Fun\u00e7\u00e3o do Ventr\u00edculo Direito e Estresse Oxidativo Melhoram com a Administra\u00e7\u00e3o de Horm\u00f4nios da Tireoide e Suco de Uva em um Modelo de Hipertens\u00e3o Pulmonar"],"prefix":"10.36660","volume":"121","author":[{"given":"Isabel","family":"Proen\u00e7a","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5994-5218","authenticated-orcid":false,"given":"Patrick","family":"Turck","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6054-4243","authenticated-orcid":false,"given":"Cristina","family":"Campos-Carraro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane Bello","family":"Klein","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre de","family":"Castro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Dani","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-7388","authenticated-orcid":false,"given":"Alex Sander da Rosa","family":"Araujo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2466-14-45","article-title":"Epidemiology and Long-term Survival of Pulmonary Arterial Hypertension in the Czech Republic: A Retrospective Analysis of a Nationwide Registry","volume":"14","author":"Jansa P","year":"2014","journal-title":"BMC Pulm Med"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cjca.2015.01.030","article-title":"A Global Perspective on the Epidemiology of Pulmonary Hypertension","volume":"31","author":"Mocumbi AO","year":"2015","journal-title":"Can J Cardiol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/2045-8932.114752","article-title":"Signal Transduction in the Development of Pulmonary Arterial Hypertension","volume":"3","author":"Malenfant S","year":"2013","journal-title":"Pulm Circ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1513\/AnnalsATS.201710-772KV","article-title":"Cor Pulmonale Revisited. From Ferrer and Harvey to the Present","volume":"15","author":"Rubin LJ","year":"2018","journal-title":"Ann Am Thorac Soc"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1139\/apnm-2019-0864","article-title":"Pterostilbene Improves Cardiac Function in a Rat Model of Right Heart Failure Through Modulation of Calcium Handling Proteins and Oxidative Stress","volume":"45","author":"Lacerda D","year":"2020","journal-title":"Appl Physiol Nutr Metab"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00045415-200209000-00003","article-title":"Primary Pulmonary Hypertension and Cor Pulmonale","volume":"10","author":"Lehrman S","year":"2002","journal-title":"Cardiol Rev"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.3390\/molecules27123724","article-title":"Oxidative Stress and Antioxidative Therapy in Pulmonary Arterial Hypertension","volume":"27","author":"Xu D","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/physrev.00036.2017","article-title":"Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation","volume":"99","author":"Tejero J","year":"2019","journal-title":"Physiol Rev"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"e0238163","DOI":"10.1371\/journal.pone.0238163","article-title":"Grape Juice Attenuates Left Ventricular Hypertrophy in Dyslipidemic Mice","volume":"15","author":"Martins AM","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"ref10","article-title":"Whole Purple Grape Juice Increases Nitric Oxide Production After Training Session in High Level Beach Handball Athletes","volume":"92","author":"Neto MM","year":"2020","journal-title":"An Acad Bras Cienc"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1111\/1750-3841.14643","article-title":"Grape Peel Extract and Resveratrol Inhibit Wrinkle Formation in Mice Model Through Activation of Nrf2\/HO-1 Signaling Pathway","volume":"84","author":"Kim J","year":"2019","journal-title":"J Food Sci"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1089\/thy.2010.0322","article-title":"Thyroid Hormone Administration Induces Rat Liver Nrf2 Activation: Suppression by N-acetylcysteine Pretreatment","volume":"21","author":"Romanque P","year":"2011","journal-title":"Thyroid"},{"issue":"1-2","key":"ref13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mce.2014.04.010","article-title":"Cardioprotective Effects of Thyroid Hormones in a Rat Model of Myocardial Infarction are Associated with Oxidative Stress Reduction","volume":"391","author":"Castro AL","year":"2014","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/jmf.2007.505","article-title":"Protective Effects of Purple Grape Juice on Carbon Tetrachloride-induced Oxidative Stress in Brains of Adult Wistar Rats","volume":"11","author":"Dani C","year":"2008","journal-title":"J Med Food"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1021\/tx00026a012","article-title":"Evaluation of the Probe 2',7'-Dichlorofluorescin as an Indicator of Reactive Oxygen Species Formation and Oxidative Stress","volume":"5","author":"LeBel CP","year":"1992","journal-title":"Chem Res Toxicol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for Lipid Peroxides in Animal Tissues by Thiobarbituric Acid Reaction","volume":"95","author":"Ohkawa H","year":"1979","journal-title":"Anal Biochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0027-5107(85)90216-7","article-title":"Superoxide Dismutase Isoenzymes in Tissues and Plasma from New Zealand Black Mice, Nude Mice and Normal BALB\/c Mice","volume":"148","author":"Marklund SL","year":"1985","journal-title":"Mutat Res"},{"key":"ref18","series-title":"Catalase in Vitro","first-page":"121","author":"Aebi H","year":"1984"},{"key":"ref19","series-title":"Methods Enzymol","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","volume-title":"Assays of Glutathione Peroxidase","volume":"105","author":"Floh\u00e9 L","year":"1984"},{"key":"ref20","series-title":"Methods Enzymol","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0076-6879(81)77050-2","volume-title":"Assay of Glutathione, Glutathione Disulfide, and Glutathione Mixed Disulfides in Biological Samples","volume":"77","author":"Akerboom TP","year":"1981"},{"issue":"1","key":"ref21","first-page":"59","article-title":"A Method for Quantification and Correction of Proteins After Transfer to Immobilization Membranes","volume":"36","author":"Klein D","year":"1995","journal-title":"Biochem Mol Biol Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.biopha.2018.04.001","article-title":"Trapidil Improves Hemodynamic, Echocardiographic and Redox State Parameters of Right Ventricle in Monocrotaline-induced Pulmonary Arterial Hypertension Model","volume":"103","author":"T\u00fcrck P","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of Physiological and Pathological Cardiac Hypertrophy","volume":"15","author":"Nakamura M","year":"2018","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1536\/ihj.14-367","article-title":"Evaluation of Right Ventricle by Speckle Tracking and Conventional Echocardiography in Rats with Right Ventricular Heart Failure","volume":"56","author":"Kimura K","year":"2015","journal-title":"Int Heart J"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/FJC.0b013e3181c87a9d","article-title":"Modulation of Monocrotaline-induced Cor Pulmonale by Grape Juice","volume":"55","author":"Ludke AR","year":"2010","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1841527","article-title":"Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature","volume":"2020","author":"V\u00e1zquez-Garza E","year":"2020","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/FJC.0b013e3182550fd6","article-title":"Effects of Purple Grape Juice in the Redox-sensitive Modulation of Right Ventricular Remodeling in a Pulmonary Arterial Hypertension Model","volume":"60","author":"Mosele F","year":"2012","journal-title":"J Cardiovasc Pharmacol"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1083\/jcb.201708007","article-title":"Superoxide Dismutases: Dual Roles in Controlling ROS Damage and Regulating ROS Signaling","volume":"217","author":"Wang Y","year":"2018","journal-title":"J Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.redox.2016.12.035","article-title":"Hydrogen Peroxide as a Central Redox Signaling Molecule in Physiological Oxidative Stress: Oxidative Eustress","volume":"11","author":"Sies H","year":"2017","journal-title":"Redox Biol"},{"issue":"19","key":"ref30","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1111\/bph.13948","article-title":"Pterostilbene Reduces Oxidative Stress, Prevents Hypertrophy and Preserves Systolic Function of Right Ventricle in Cor Pulmonale Model","volume":"174","author":"Lacerda DS","year":"2017","journal-title":"Br J Pharmacol"},{"issue":"6","key":"ref31","article-title":"Selenium and Copper as Biomarkers for Pulmonary Arterial Hypertension in Systemic Sclerosis","volume":"12","author":"Sun Q","year":"2020","journal-title":"Nutrients"},{"issue":"3","key":"ref32","first-page":"60","article-title":"The Effect of Consumption of Purple Grape Juice in the Gestational Period on Oxidative Stress Parameters in Wistar Rat Foetuses","volume":"12","author":"Proen\u00e7a ICT","year":"2021","journal-title":"Int J Biochem Mol Biol"},{"issue":"23","key":"ref33","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1080\/14786419.2020.1747458","article-title":"Effect of Grape Juice, Red Wine and Resveratrol Solution on Antioxidant, Anti-inflammatory, Hepactic Function and Lipid Profile in Rats Feds with High-fat Diet","volume":"35","author":"Bed\u00ea TP","year":"2021","journal-title":"Nat Prod Res"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/ajpheart.00321.2019","article-title":"Sulforaphane Prevents Right Ventricular Injury and Reduces Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension","volume":"318","author":"Kang Y","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1152\/ajpcell.00454.2007","article-title":"Role of Extracellular Superoxide in Neutrophil Activation: Interactions Between Xanthine Oxidase and TLR4 Induce Proinflammatory Cytokine Production","volume":"294","author":"Lorne E","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.mce.2017.09.003","article-title":"Thyroid Hormones Decrease the Proinflammatory TLR4\/NF-?\u00df Pathway and Improve Functional Parameters of the Left Ventricle of Infarcted Rats","volume":"461","author":"Castro AL","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"ref37","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.15528.1","article-title":"Hsp70 Chaperone: A Master Player in Protein Homeostasis","volume":"7","author":"Fern\u00e1ndez-Fern\u00e1ndez MR","year":"2018","journal-title":"F1000Res"}],"container-title":["Arquivos Brasileiros de Cardiologia"],"original-title":["Right Ventricular Function and Oxidative Stress Improve with the Administration of Thyroid Hormones and Grape Juice in a Pulmonary Hypertension Model"],"link":[{"URL":"https:\/\/abccardiol.org\/wp-content\/uploads\/articles_xml\/0066-782X-abc-121-7-e20230602\/0066-782X-abc-121-7-e20230602.x47225.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T15:54:12Z","timestamp":1721750052000},"score":1,"resource":{"primary":{"URL":"https:\/\/abccardiol.org\/article\/funcao-do-ventriculo-direito-e-estresse-oxidativo-melhoram-com-a-administracao-de-hormonios-da-tireoide-e-suco-de-uva-em-um-modelo-de-hipertensao-pulmonar\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":37,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024]]}},"alternative-id":["S0066-782X2024000700301"],"URL":"https:\/\/doi.org\/10.36660\/abc.20230602","relation":{"is-translation-of":[{"id-type":"doi","id":"10.36660\/abc.20230602i","asserted-by":"subject"},{"id-type":"doi","id":"10.36660\/abc.20230602i","asserted-by":"object"}]},"ISSN":["1678-4170","0066-782X"],"issn-type":[{"value":"1678-4170","type":"electronic"},{"value":"0066-782X","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e20230602"}}