{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:19Z","timestamp":1772253139633,"version":"3.50.1"},"reference-count":25,"publisher":"Sociedade Brasileira de Cardiologia","issue":"7","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento: Na hipertens\u00e3o pulmonar (HP), \u00e9 necess\u00e1ria a identifica\u00e7\u00e3o de marcadores progn\u00f3sticos de f\u00e1cil obten\u00e7\u00e3o associados com disfun\u00e7\u00e3o do ventr\u00edculo direito (VD) e sobrevida.  Objetivo: Avaliar a associa\u00e7\u00e3o do \u00edndice de anisocitose eritrocit\u00e1ria (RDW, do ingl\u00eas red cell distribution width) com par\u00e2metros ecocardiogr\u00e1ficos e sobrevida em pacientes com HP pr\u00e9-capilar, com o desenvolvimento de um modelo de predi\u00e7\u00e3o de mortalidade.  M\u00e9todos: Estudo observacional, longitudinal, prospectivo, conduzido entre maio de 2019 e dezembro de 2022. Trinta e quatro pacientes com HP pr\u00e9-capilar submeteram-se \u00e0 realiza\u00e7\u00e3o de ecocardiograma bidimensional e hemograma. Um ponto de corte de 14,5% foi adotado para definir o RDW como alterado (\u226514,5%) ou normal (&lt;14,5%). Valores de p&lt;0,05 foram considerados significativos.  Resultados: O RDW m\u00e9dio foi 14,4%. Houve uma diferen\u00e7a significativa na satura\u00e7\u00e3o perif\u00e9rica de oxig\u00eanio (SpO2) (p=0,028), strain do VD (p=0,047) e derrame peric\u00e1rdico (p=0,002) entre os grupos com RDW normal e elevado. Durante um per\u00edodo mediano de 15 meses, 20,6% dos pacientes foram a \u00f3bito. Os pacientes com RDW aumentado tiveram uma sobrevida global mais curta (44,7%, log-rank p=0,019), sendo um preditor de mortalidade na regress\u00e3o univariada de Cox. A adi\u00e7\u00e3o do strain do VD &lt; 16% e da SpO2 \u226493% ao modelo incluindo somente RDW mostrou valor incremental na predi\u00e7\u00e3o de mortalidade (\u03c72=8,2, p=0,049; \u03c72=12,4, p=0,041), com \u00e1rea sob a curva ROC (do ingl\u00eas, Receiver Operating Characteristic) aumentada (0,729 vs. 0,837 vs. 0,909) e probabilidade de sobrevida diminu\u00edda (44.7% vs. 35.6% vs. 25%, log-rank p=0,019).  Conclus\u00f5es: O RDW fornece informa\u00e7\u00f5es sobre a gravidade da HP pr\u00e9-capilar pela sua correla\u00e7\u00e3o com par\u00e2metros ecocardiogr\u00e1ficos de disfun\u00e7\u00e3o do VD e mortalidade, a qual \u00e9 melhor predita por um modelo incluindo RDW, strain do VD e SpO2.<\/jats:p>","DOI":"10.36660\/abc.20230669","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T11:09:02Z","timestamp":1724065742000},"source":"Crossref","is-referenced-by-count":0,"title":["Novo Modelo Incremental para Predi\u00e7\u00e3o de Mortalidade na Hipertens\u00e3o Pulmonar Pr\u00e9-Capilar"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2828-479X","authenticated-orcid":false,"given":"Andressa Alves de","family":"Carvalho","sequence":"first","affiliation":[{"name":"Universidade Federal da Para\u00edba,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanessa Alves 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