{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:24:32Z","timestamp":1778048672827,"version":"3.51.4"},"reference-count":36,"publisher":"Sociedade Brasileira de Cardiologia","issue":"5","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  Estudos pr\u00e9vios t\u00eam sido inconsistentes em demonstrar efeitos cardiovasculares ben\u00e9ficos da suplementa\u00e7\u00e3o de vitamina D.  Objetivo  Avaliar efeitos da suplementa\u00e7\u00e3o de vitamina D3 sobre par\u00e2metros hemodin\u00e2micos centrais e atividade auton\u00f4mica em indiv\u00edduos obesos\/sobrepeso e baixos n\u00edveis de vitamina D (&lt;30ng\/dl).  M\u00e9todos  Ensaio cl\u00ednico prospectivo, randomizado, duplo-cego (NCT 05689632), adultos 40-65 anos com \u00edndice de massa corporal \u226525&lt;40 kg\/m2. Hemodin\u00e2mica central avaliada por m\u00e9todo oscilom\u00e9trico (Mobil-O-Graph\u00ae), variabilidade da frequ\u00eancia card\u00edaca utilizando frequenc\u00edmetro Polar (software Kubios\u00ae). Os pacientes (n=53) receberam placebo no grupo controle (CO, n=25) ou vitamina D3 (VD, n=28) 7000 UI\/dia, avaliados antes (S0) e ap\u00f3s 8 semanas (S8) com n\u00edvel de signific\u00e2ncia de 0,05.  Resultados  Os grupos foram homog\u00eaneos na idade (51\u00b16 vs. 52\u00b16 anos, p=0,509) e n\u00edveis de vitamina D (22,8\u00b14,9 vs. 21,7\u00b14,5ng\/ml, p=0,590). Na S8, o grupo VD apresentou n\u00edveis significativamente maiores de vitamina D (22,5 vs. 35,6ng\/ml, p&lt;0,001). Apenas o grupo VD mostrou redu\u00e7\u00e3o significativa da press\u00e3o arterial sist\u00f3lica (PAS; 123\u00b115 vs. 119\u00b114mmHg, p=0,019) e fosfatase alcalina (213\u00b155 vs. 202\u00b155mg\/dl, p=0,012). O grupo CO mostrou eleva\u00e7\u00e3o da press\u00e3o de aumento (AP: 9 vs. 12mmHg, p=0,028) e do \u00edndice de incremento (Aix: 26 vs. 35%, p=0,020), o que n\u00e3o foi observado no grupo VD (AP: 8 vs. 8mmHg, Aix: 26 vs. 25%, p&gt;0,05). Grupo VD apresentou aumento no \u00edndice do sistema nervoso (iSN) parassimp\u00e1tico (-0,64\u00b10,94 vs. -0,16\u00b11,10, p=0,028) e no intervalo R-R (866\u00b1138 vs. 924\u00b1161ms, p=0,026).  Conclus\u00e3o  Nesta amostra, a suplementa\u00e7\u00e3o di\u00e1ria de vitamina D durante oito semanas resultou em melhora dos n\u00edveis press\u00f3ricos, par\u00e2metros hemodin\u00e2micos centrais e do equil\u00edbrio auton\u00f4mico.<\/jats:p>","DOI":"10.36660\/abc.20230678","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T09:20:52Z","timestamp":1717665652000},"source":"Crossref","is-referenced-by-count":4,"title":["Efeitos da Suplementa\u00e7\u00e3o de Vitamina D sobre Par\u00e2metros Hemodin\u00e2micos Centrais e Sistema Nervoso Aut\u00f4nomo em Indiv\u00edduos com Obesidade ou Sobrepeso"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8749-9324","authenticated-orcid":false,"given":"Adriana C. C.","family":"Faria","sequence":"first","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Lyra","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-572X","authenticated-orcid":false,"given":"Michelle Rabello da","family":"Cunha","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brasil; Universidade do Estado do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samanta","family":"Mattos","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wille","family":"Oigman","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Fritsch","family":"Neves","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"21","key":"ref1","first-page":"e984","article-title":"Obesity and Cardiovascular Disease: a Scientific Statement from the American Heart Association","volume":"143","author":"Powell-Wiley TM","year":"2021","journal-title":"Circulation"},{"issue":"3","key":"ref2","first-page":"70","article-title":"O Papel das Adipocitocinas Leptina e Adiponectina no Desenvolvimento da Obesidade","volume":"9","author":"Silva N","year":"2019","journal-title":"Rev Bras Educ Saude"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ddmec.2013.03.006","article-title":"Obesity and Metabolic Inflammation","volume":"10","author":"Xu 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