{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:19Z","timestamp":1772253139416,"version":"3.50.1"},"reference-count":65,"publisher":"Sociedade Brasileira de Cardiologia","issue":"7","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  Os antagonistas da vitamina K (AVKs) s\u00e3o o tratamento de primeira linha recomendado para trombo ventricular esquerdo (TVE); entretanto, os anticoagulantes orais diretos (AODs) t\u00eam sido considerados uma terapia alternativa.  Objetivos  Avaliar a efic\u00e1cia e a seguran\u00e7a dos AODs em compara\u00e7\u00e3o com a terapia com AVKs em pacientes com TVE.  M\u00e9todos  PubMed, Embase e Cochrane foram sistematicamente pesquisados em busca de ensaios cl\u00ednicos randomizados ou estudos de coorte que comparassem AODs versus AVKs para TVE. As raz\u00f5es de risco (RR) foram calculadas para desfechos bin\u00e1rios, com intervalos de confian\u00e7a (IC) de 95%. A signific\u00e2ncia estat\u00edstica foi definida como valor de p &lt; 0,05.  Resultados  Foram inclu\u00eddos um total de 4 ensaios cl\u00ednicos randomizados e 29 estudos de coorte, com 4.450 pacientes designados para AODs ou AVKs. N\u00e3o houve diferen\u00e7a significativa entre os grupos para acidente vascular cerebral ou eventos emb\u00f3licos sist\u00eamicos (AVC\/EES) (RR 0,84; IC 95% 0,65 a 1,07; p = 0,157), acidente vascular cerebral (RR 0,73; IC 95% 0,48 a 1,11; p = 0,140), eventos emb\u00f3licos sist\u00eamicos (EES) (RR 0,69; IC 95% 0,40 a 1,17; p = 0,166), resolu\u00e7\u00e3o do trombo (RR 1,05; IC 95% 0,99 a 1,11; p = 0,077), qualquer sangramento (RR 0,78; IC 95% 0,60 a 1,00; p = 0,054), sangramento clinicamente relevante (RR 0,69; IC 95% 0,46 a 1,03; p = 0,066), sangramento menor (RR 0,73; IC 95% 0,43 a 1,23; p = 0,234), sangramento maior (RR 0,87; IC 95% 0,42 a 1,80; p = 0,705) e mortalidade por todas as causas (RR 1,05; IC 95% 0,79 a 1,39; p = 0,752). Em compara\u00e7\u00e3o com AVKs, a rivaroxabana reduziu significativamente AVC\/EES (RR 0,35; IC 95% 0,16 a 0,91; p = 0,029) e EES (RR 0,39; IC 95% 0,16 a 0,95; p = 0,037).  Conclus\u00f5es  Os AODs tiveram uma taxa semelhante de eventos tromboemb\u00f3licos e hemorr\u00e1gicos, bem como de resolu\u00e7\u00e3o do trombo, em compara\u00e7\u00e3o com os AVKs no tratamento de TVE. A terapia com rivaroxabana teve uma redu\u00e7\u00e3o significativa nos eventos tromboemb\u00f3licos, em compara\u00e7\u00e3o com os AVKs.<\/jats:p>","DOI":"10.36660\/abc.20230738","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T10:32:49Z","timestamp":1724063569000},"source":"Crossref","is-referenced-by-count":0,"title":["Anticoagulantes Orais Diretos versus Antagonistas da Vitamina K para Trombo Ventricular Esquerdo: Uma Metan\u00e1lise com An\u00e1lise Sequencial de Ensaios"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6484-1162","authenticated-orcid":false,"given":"Eric","family":"Pasqualotto","sequence":"first","affiliation":[{"name":"Universidade Federal de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-2445","authenticated-orcid":false,"given":"Douglas Mesadri","family":"Gewehr","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie do Paran\u00e1,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-0509","authenticated-orcid":false,"given":"Rafael Oliva Morgado","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Pedrotti","family":"Chavez","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-004X","authenticated-orcid":false,"given":"Caroliny Hellen","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-9627","authenticated-orcid":false,"given":"Sara Almeida","family":"Cruz","sequence":"additional","affiliation":[{"name":"Immanuel Kant Baltic Federal University,  R\u00fassia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1869-2362","authenticated-orcid":false,"given":"Jhonny","family":"Limachi-Choque","sequence":"additional","affiliation":[{"name":"Universidad Mayor de San Sim\u00f3n,  Bol\u00edvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5142-7723","authenticated-orcid":false,"given":"Amanda","family":"Park","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Lus\u00edada,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8025-9084","authenticated-orcid":false,"given":"M\u00e1rio S\u00e9rgio Soares de Azeredo","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Fernando","family":"Kubrusly","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie do Paran\u00e1,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"14","key":"ref1","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/j.jacc.2020.01.057","article-title":"Antithrombotic Therapy for Patients with Left Ventricular Mural Thrombus","volume":"75","author":"Lattuca B","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"ref2","first-page":"153","article-title":"Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association","volume":"145","author":"Tsao CW","year":"2022","journal-title":"Circulation"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/1753944717711139","article-title":"Challenges in Management of Left Ventricular Thrombus","volume":"11","author":"Habash F","year":"2017","journal-title":"Ther Adv Cardiovasc Dis"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1001\/jamacardio.2018.1086","article-title":"Left Ventricular Thrombus After Acute Myocardial Infarction: Screening, Prevention, and Treatment","volume":"3","author":"McCarthy CP","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/STR.0000000000000375","article-title":"2021 Guideline for the Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association\/American Stroke Association","volume":"52","author":"Kleindorfer DO","year":"2021","journal-title":"Stroke"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting with ST-segment Elevation: The Task Force for the Management of Acute Myocardial Infarction in Patients Presenting with ST-segment Elevation of the European Society of Cardiology (ESC)","volume":"39","author":"Ibanez B","year":"2018","journal-title":"Eur Heart J"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jacc.2022.01.011","article-title":"Left Ventricular Thrombus Following Acute Myocardial Infarction: JACC State-of-the-Art Review","volume":"79","author":"Camaj A","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/ehjcvp\/pvab057","article-title":"Apixaban vs. Warfarin in Patients with Left Ventricular Thrombus: A Prospective Multicentre Randomized Clinical Trial","volume":"8","author":"Alcalai R","year":"2022","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"15","key":"ref9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/CIR.0000000000001092","article-title":"Management of Patients at Risk for and with Left Ventricular Thrombus: A Scientific Statement From the American Heart Association","volume":"146","author":"Levine GN","year":"2022","journal-title":"Circulation"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.amjcard.2019.05.009","article-title":"Efficacy of Direct Acting Oral Anticoagulants in Treatment of Left Ventricular Thrombus","volume":"124","author":"Fleddermann AM","year":"2019","journal-title":"Am J Cardiol"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1001\/jamacardio.2020.0652","article-title":"Off-label Use of Direct Oral Anticoagulants Compared with Warfarin for Left Ventricular Thrombi","volume":"5","author":"Robinson AA","year":"2020","journal-title":"JAMA Cardiol"},{"key":"ref12","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page MJ","year":"2021","journal-title":"BMJ"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A Revised Tool for Assessing Risk of Bias in Randomised Trials","volume":"366","author":"Sterne JAC","year":"2019","journal-title":"BMJ"},{"key":"ref14","article-title":"ROBINS-I: A Tool for Assessing Risk of Bias in Non-randomised Studies of Interventions","volume":"355","author":"Sterne JA","year":"2016","journal-title":"BMJ"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/jep.13016","article-title":"The Evolution of GRADE (Part 3): A Framework Built on Science or Faith?","volume":"24","author":"Mercuri M","year":"2018","journal-title":"J Eval Clin Pract"},{"issue":"7109","key":"ref16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in Meta-analysis Detected by a Simple, Graphical Test","volume":"315","author":"Egger M","year":"1997","journal-title":"BMJ"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating Characteristics of a Rank Correlation Test for Publication Bias","volume":"50","author":"Begg CB","year":"1994","journal-title":"Biometrics"},{"issue":"7414","key":"ref18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring Inconsistency in Meta-analyses","volume":"327","author":"Higgins JP","year":"2003","journal-title":"BMJ"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2307\/1267913","article-title":"Restricted Maximum Likelihood (REML) Estimation of Variance Components in the Mixed Model","volume":"18","author":"Corbeil RR","year":"1976","journal-title":"Technometrics"},{"key":"ref20","series-title":"User Manual for Trial Sequential Analysis (TSA)","year":"2017"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","DOI":"10.1186\/s43044-021-00164-7","article-title":"Rivaroxaban Versus Warfarin for the Management of Left Ventricle Thrombus","volume":"73","author":"Albabtain MA","year":"2021","journal-title":"Egypt Heart J"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.jacc.2021.01.049","article-title":"Comparative Study of Oral Anticoagulation in Left Ventricular Thrombi (No-LVT Trial)","volume":"77","author":"Abdelnabi M","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1161\/circ.144.suppl_1.11251","article-title":"Warfarin Versus Direct Oral Anticoagulants for the Treatment of Left Ventricular Thrombus; A Multicenter Retrospective Observational Study","volume":"144","author":"Al-Abcha A","year":"2021","journal-title":"Circulation"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","DOI":"10.1016\/S0735-1097(22)02747-4","article-title":"Direct Oral Anticoagulants Compared with Warfarin for the Treatment of Left Ventricular Thrombi","volume":"79","author":"Aldaas O","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"ref25","article-title":"Direct Oral Anticoagulant Use in Left Ventricular Thrombus","volume":"18","author":"Ali Z","year":"2020","journal-title":"Thromb J"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehz746.1020","article-title":"The Use of Direct Oral Anti-coagulations (DOACs) Compared to Vitamin K Antagonist in Patients with Left Ventricular Thrombus After Acute Myocardial Infarction","volume":"40","author":"Alizadeh M","year":"2019","journal-title":"Eur Heart J"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11239-020-02371-6","article-title":"Comparative Effectiveness of Direct Oral Anticoagulants and Warfarin for the Treatment of Left Ventricular Thrombus","volume":"52","author":"Bass ME","year":"2021","journal-title":"J Thromb Thrombolysis"},{"key":"ref28","article-title":"Direct Oral Anticoagulants Compared with Warfarin for the Treatment of Left Ventricular Thrombosis Post Myocardial Infarction","volume":"6","author":"Byrne R","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/1074248420967644","article-title":"Direct Oral Anticoagulants in the Treatment of Left Ventricular Thrombus: A Retrospective, Multicenter Study and Meta-Analysis of Existing Data","volume":"26","author":"Cochran JM","year":"2021","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1161\/circ.146.suppl_1.12863","article-title":"Similar Rates of Embolic and Bleeding Events for Direct Oral Anticoagulants and Warfarin in the Treatment of Left Ventricular Thrombus","volume":"146","author":"Conant A","year":"2022","journal-title":"Circulation"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s40261-020-00898-3","article-title":"Management of Left Ventricular Thrombi with Direct Oral Anticoagulants: Retrospective Comparative Study with Vitamin K Antagonists","volume":"40","author":"Daher J","year":"2020","journal-title":"Clin Drug Investig"},{"issue":"3","key":"ref32","article-title":"Direct Oral Anticoagulans Versus Vitamin K-Antagonists for Treatment of Left Ventricular Thrombus-Insights from Multicenter Registry","volume":"33","author":"Durrer-Ariyakuddy K","year":"2019","journal-title":"Cardiovasc Med"},{"key":"ref33","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehz747.0118","article-title":"Direct Oral Anticoagulants are an Effective Therapy for Left Ventricular Thrombus Formation","volume":"40","author":"Gama F","year":"2019","journal-title":"Eur Heart J"},{"issue":"12","key":"ref34","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.amjmed.2020.05.025","article-title":"Treatment of Left Ventricular Thrombus with Direct Oral Anticoagulants: A Retrospective Observational Study","volume":"133","author":"Guddeti RR","year":"2020","journal-title":"Am J Med"},{"issue":"7","key":"ref35","first-page":"729","article-title":"Direct Oral Anticoagulants Versus Warfarin for the Treatment of Left Ventricular Thrombus in Patients with Reduced Ejection Fraction Heart Failure","volume":"5","author":"Harb K","year":"2022","journal-title":"J Am Coll Clin Pharm"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/ehf2.12718","article-title":"Direct Oral Anticoagulants Compared to Vitamin K Antagonist for the Management of Left Ventricular Thrombus","volume":"7","author":"Iqbal H","year":"2020","journal-title":"ESC Heart Fail"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/FJC.0000000000000987","article-title":"Evaluation of Direct Oral Anticoagulants Versus Warfarin for Intracardiac Thromboses","volume":"77","author":"Iskaros O","year":"2021","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref38","doi-asserted-by":"crossref","DOI":"10.1161\/circ.142.suppl_3.15803","article-title":"Effectiveness of Direct Oral Anticoagulant versus Warfarin in the Treatment of Left Ventricular Thrombus","volume":"142","author":"Isom N","year":"2020","journal-title":"Circulation"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cjca.2018.07.194","article-title":"Treatment of Left Ventricular Thrombus Using Warfarin Versus Direct Oral Anticoagulants Following Anterior Myocardial Infarction","volume":"34","author":"Jaidka A","year":"2018","journal-title":"Can J Cardiol"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/ehjcvp\/pvaa096","article-title":"The Use of Novel Oral Anticoagulants Compared to Vitamin K Antagonists (Warfarin) in Patients with Left Ventricular Thrombus After Acute Myocardial Infarction","volume":"7","author":"Jones DA","year":"2021","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"ref41","doi-asserted-by":"crossref","DOI":"10.1161\/circ.142.suppl_3.16816","article-title":"Direct Oral Anticoagulants Compared to Warfarin for the Treatment of Left Ventricular Thrombus: A Multi-Center Experience","volume":"142","author":"Minciunescu A","year":"2020","journal-title":"Circulation"},{"key":"ref42","doi-asserted-by":"crossref","DOI":"10.1016\/S0735-1097(18)31522-5","article-title":"Direct Oral Anticoagulants Compared to Warfarin for Left Ventricular Thrombi: A Single Center Experience","volume":"71","author":"Robinson A","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"ref43","first-page":"3","article-title":"Direct Oral Anticoagulants Compared to Vitamin K-antagonists in Patients with Left Ventricular Thrombus","volume":"152","author":"Seiler T","year":"2022","journal-title":"Swiss Med Wkly"},{"issue":"7","key":"ref44","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1177\/1060028020975111","article-title":"Direct Oral Anticoagulants Versus Warfarin in the Treatment of Left Ventricular Thrombus","volume":"55","author":"Willeford A","year":"2021","journal-title":"Ann Pharmacother"},{"issue":"9","key":"ref45","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.21037\/apm-21-1683","article-title":"Direct Oral Anticoagulants Versus Vitamin K Antagonists for Patients with Left Ventricular Thrombus","volume":"10","author":"Xu Z","year":"2021","journal-title":"Ann Palliat Med"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","DOI":"10.1016\/S0735-1097(20)31575-8","article-title":"Direct Oral Anticoagulants are Effective Therapy in Treating Left Ventricular Thrombi","volume":"75","author":"Yunis A","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00380-021-01921-z","article-title":"Rivaroxaban Versus Vitamin K Antagonists (Warfarin) Based on the Triple Therapy for Left Ventricular Thrombus After ST-Elevation Myocardial Infarction","volume":"37","author":"Zhang Z","year":"2022","journal-title":"Heart Vessels"},{"key":"ref48","article-title":"Rivaroxaban in Heart Failure Patients with Left Ventricular Thrombus: A Retrospective Study","volume":"13","author":"Zhang Q","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref49","series-title":"NCT02982590: Apixaban Versus Warfarin in Patients with Left Ventricular Thrombus","author":"Haniff WY","year":"2021"},{"issue":"8","key":"ref50","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s11739-021-02788-8","article-title":"Direct Oral Anticoagulants Versus Warfarin for the Treatment of Left Ventricular Thrombosis","volume":"16","author":"Mihm AE","year":"2021","journal-title":"Intern Emerg Med"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cjco.2022.12.003","article-title":"Apixaban in Patients with Post-Myocardial Infarction Left Ventricular Thrombus: A Randomized Clinical Trial","volume":"5","author":"Youssef AA","year":"2022","journal-title":"CJC Open"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1378\/chest.11-2306","article-title":"Primary and Secondary Prevention of Cardiovascular Disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Vandvik PO","year":"2012","journal-title":"Chest"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/ehjcvp\/pvaa066","article-title":"Left Ventricular Thrombosis: New Perspectives on an Old Problem","volume":"7","author":"Massussi M","year":"2021","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/eurheartj\/ehx551","article-title":"Anticoagulation Combined with Antiplatelet Therapy in Patients with Left Ventricular Thrombus After First Acute Myocardial Infarction","volume":"39","author":"Maniwa N","year":"2018","journal-title":"Eur Heart J"},{"issue":"15","key":"ref55","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/j.jacc.2019.01.031","article-title":"Left Ventricular Thrombus: Contemporary Etiologies, Treatment Strategies, and Outcomes","volume":"73","author":"McCarthy CP","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"ref56","first-page":"362","article-title":"2013 ACCF\/AHA Guideline for the Management of ST-elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"127","author":"O'Gara PT","year":"2013","journal-title":"Circulation"},{"issue":"6","key":"ref57","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/FJC.0000000000001270","article-title":"Direct Oral Anticoagulants Versus Vitamin K Antagonists for the Treatment of Left Ventricular Thrombus: An Updated Meta-Analysis of Cohort Studies and Randomized Controlled Trials","volume":"79","author":"Chen Y","year":"2022","journal-title":"J Cardiovasc Pharmacol"},{"issue":"16","key":"ref58","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1093\/eurheartj\/ehy136","article-title":"The 2018 European Heart Rhythm Association Practical Guide on the Use of non-vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation","volume":"39","author":"Steffel J","year":"2018","journal-title":"Eur Heart J"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"e0197583","DOI":"10.1371\/journal.pone.0197583","article-title":"Efficacy and Safety of Direct Oral Anticoagulants Approved for Cardiovascular Indications: Systematic Review and Meta-analysis","volume":"13","author":"Makam RCP","year":"2018","journal-title":"PLoS One"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev-med-042617-092334","article-title":"Non-Vitamin K Antagonist Oral Anticoagulants in the Treatment of Atrial Fibrillation","volume":"70","author":"Fanaroff AC","year":"2019","journal-title":"Annu Rev Med"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.repc.2021.11.013","article-title":"Effect of Direct Oral Anticoagulants Versus Vitamin K Antagonists or Warfarin in Patients with Left Ventricular Thrombus Outcomes: A Systematic Review and Meta-analysis","volume":"42","author":"Ferreira HS","year":"2023","journal-title":"Rev Port Cardiol"},{"issue":"9","key":"ref62","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.cjco.2021.04.007","article-title":"Direct Oral Anticoagulants vs Vitamin K Antagonists in Left Ventricular Thrombi: A Systematic Review and Meta-analysis","volume":"3","author":"Michael F","year":"2021","journal-title":"CJC Open"},{"issue":"9","key":"ref63","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1080\/00015385.2020.1858538","article-title":"Direct Oral Anticoagulants vs. Vitamin K Antagonists for Left Ventricular Thrombus: A Systematic Review and Meta-analysis","volume":"76","author":"Trongtorsak A","year":"2021","journal-title":"Acta Cardiol"},{"issue":"6","key":"ref64","doi-asserted-by":"crossref","first-page":"e0252549","DOI":"10.1371\/journal.pone.0252549","article-title":"Meta-analysis Comparing Direct Oral Anticoagulants Versus Vitamin K Antagonists in Patients with Left Ventricular Thrombus","volume":"16","author":"Kido K","year":"2021","journal-title":"PLoS One"},{"issue":"9","key":"ref65","article-title":"Direct Oral Anticoagulants versus Vitamin K Antagonists for the Treatment of Left Ventricular Thrombosis: A Meta-Analysis","volume":"23","author":"Li J","year":"2022","journal-title":"Rev Cardiovasc Med"}],"container-title":["Arquivos Brasileiros de Cardiologia"],"original-title":["Direct Oral Anticoagulants versus Vitamin K Antagonists for Left Ventricular Thrombus: A Meta-Analysis with Trial Sequential Analysis"],"link":[{"URL":"https:\/\/abccardiol.org\/wp-content\/uploads\/articles_xml\/0066-782X-abc-121-7-e20230738\/0066-782X-abc-121-7-e20230738.x47225.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T10:33:24Z","timestamp":1724063604000},"score":1,"resource":{"primary":{"URL":"https:\/\/abccardiol.org\/article\/anticoagulantes-orais-diretos-versus-antagonistas-da-vitamina-k-para-trombo-ventricular-esquerdo-uma-metanalise-com-analise-sequencial-de-ensaios\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":65,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024]]}},"alternative-id":["S0066-782X2024000700305"],"URL":"https:\/\/doi.org\/10.36660\/abc.20230738","relation":{"is-translation-of":[{"id-type":"doi","id":"10.36660\/abc.20230738i","asserted-by":"subject"},{"id-type":"doi","id":"10.36660\/abc.20230738i","asserted-by":"object"}]},"ISSN":["1678-4170","0066-782X"],"issn-type":[{"value":"1678-4170","type":"electronic"},{"value":"0066-782X","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e20230738"}}