{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:51Z","timestamp":1772253231511,"version":"3.50.1"},"reference-count":48,"publisher":"Sociedade Brasileira de Cardiologia","issue":"12","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  O \u00f3xido n\u00edtrico (NO) desempenha um papel importante na regula\u00e7\u00e3o da press\u00e3o arterial (PA), atuando diretamente na resist\u00eancia vascular perif\u00e9rica por meio da vasodilata\u00e7\u00e3o. O treinamento f\u00edsico (via eNOS\/NO) e a ingest\u00e3o de nitrito foram considerados os principais est\u00edmulos para o aumento do NO.  Objetivo  No presente estudo, examinamos os efeitos da administra\u00e7\u00e3o oral de nitrito e do treinamento com exerc\u00edcios aer\u00f3bicos sobre a PA e rigidez arterial de ratos Wistar.  M\u00e9todos  Trinta e nove (39) ratos Wistar machos jovens foram divididos nos seguintes grupos (n=9 ou 10 por grupo): Sedent\u00e1rio-Controle (SC), Sedent\u00e1rio-Nitrito (SN), Treinado-Controle (TC) e Treinado-Nitrito (TN). Eles foram submetidos a treinamento f\u00edsico aer\u00f3bico em esteiras por 8 semanas (50-60% da capacidade f\u00edsica, 1h\/dia, 5 dias\/semana) ou mantidos sedent\u00e1rios. Nos \u00faltimos 6 dias de treinamento, nitrito foi administrado oralmente (15 mg\/Kg por gavagem). A PA, a rigidez arterial e as concentra\u00e7\u00f5es plasm\u00e1ticas e teciduais de nitrito foram avaliadas ap\u00f3s o treinamento e o per\u00edodo de administra\u00e7\u00e3o oral de nitrito. O n\u00edvel de signific\u00e2ncia foi definido como p &lt; 0,05.  Resultados  A administra\u00e7\u00e3o oral de nitrito foi eficaz na redu\u00e7\u00e3o dos valores de rigidez arterial (TN, -23%; e SN, -15%). Ambos os grupos que tiveram apenas um tipo de interven\u00e7\u00e3o apresentaram PA sist\u00f3lica menor em compara\u00e7\u00e3o com o controle (TC vs. SC, -14,23; e SN vs. SC, - 12,46).  Conclus\u00e3o  Assim, conclu\u00edmos que a administra\u00e7\u00e3o oral de curta dura\u00e7\u00e3o (6 dias), associada a um programa de treinamento f\u00edsico aer\u00f3bico promovem diversos benef\u00edcios hemodin\u00e2micos em ratos Wistar machos, como melhorias na rigidez arterial e na PA. Essas respostas sugerem que o treinamento f\u00edsico e a suplementa\u00e7\u00e3o de nitrito de s\u00f3dio podem ser alternativas satisfat\u00f3rias para a preven\u00e7\u00e3o e tratamento da hipertens\u00e3o.<\/jats:p>","DOI":"10.36660\/abc.20230783","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T11:43:32Z","timestamp":1734090212000},"source":"Crossref","is-referenced-by-count":0,"title":["A Administra\u00e7\u00e3o Oral de Nitrito a Curto Prazo Diminui a Rigidez Arterial em Ratos Wistar Treinados e Sedent\u00e1rios"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5411-5095","authenticated-orcid":false,"given":"Thiago Pereira","family":"Souza","sequence":"first","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidieli Pazin","family":"Tardelli","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Carlos,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Antunes","family":"Nicoletti","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5445-429X","authenticated-orcid":false,"given":"Andr\u00e9 Mour\u00e3o","family":"Jacomini","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Francisco de Mello","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas C\u00e9zar","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-9633","authenticated-orcid":false,"given":"Jos\u00e9 Eduardo","family":"Tanus-Santos","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Lia do","family":"Amaral","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson Saranz","family":"Zago","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"16","key":"ref1","doi-asserted-by":"crossref","DOI":"10.3390\/s20164484","article-title":"Blood Pressure Sensors: Materials, Fabrication Methods, Performance Evaluations and Future 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