{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:19Z","timestamp":1772253139476,"version":"3.50.1"},"reference-count":36,"publisher":"Sociedade Brasileira de Cardiologia","issue":"7","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  N\u00e3o houve evid\u00eancia cient\u00edfica sobre o tratamento inicial com solu\u00e7\u00e3o salina hipert\u00f4nica (SSH) na insufici\u00eancia card\u00edaca agudamente descompensada (ICAD).  Objetivos  Este estudo avaliou o impacto do uso de SSH junto com um diur\u00e9tico de al\u00e7a (DA) como o primeiro tratamento diur\u00e9tico para ICAD, com foco na fun\u00e7\u00e3o renal, n\u00edveis de eletr\u00f3litos e resultados cl\u00ednicos.  M\u00e9todos  Neste estudo retrospectivo de caso-controle, 171 pacientes adultos (93 mulheres\/78 homens) com ICAD foram inclu\u00eddos entre 1\u00ba de janeiro de 2022 e 31 de dezembro de 2022. Os pacientes foram alocados em dois grupos: combina\u00e7\u00e3o inicial de SSH+DA e DA padronizada. O desfecho prim\u00e1rio foi piora da fun\u00e7\u00e3o renal (PFR). A hospitaliza\u00e7\u00e3o por IC e a mortalidade por todas as causas foram avaliadas durante 6 meses de acompanhamento. O n\u00edvel de signific\u00e2ncia adotado na an\u00e1lise estat\u00edstica foi de 5%.  Resultados  Os grupos exibiram semelhan\u00e7as nas caracter\u00edsticas basais. Diurese significativamente maior no 1\u00ba dia (3975 [3000-5150] vs. 2583 [2000-3250], p=0,001) e natriurese na 2\u00aa hora (116,00 [82,75-126,00] vs. 131,75-140,00] vs. 94,00-103,25] vs. 99,00 [96,00-103,00], p=0,295), TFG (48,50 [29,75-72,50 vs. 50,00[35,50-63,50, p=0,616) e creatinina (1,20 [0,90-1,70] vs. 1,20 [1,00-1,50], p=0,218) permaneceu est\u00e1vel no grupo SSH combinado inicial quando comparado ao grupo DA padronizado (Cl-: 102,00[99,00-106,00] vs. 98,00[95,00-103,00], p=0,001, TFGe: 56,00 [41,00-71,00] vs. 55,00[35,00-71,00], p=0,050, creatinina: 1,10[0,90-1,40] vs. 1,20 [0,90-1,70], p=0,009). A piora da fun\u00e7\u00e3o renal (16,1% vs. 35,5%, p = 0,007) e o tempo de interna\u00e7\u00e3o hospitalar (4 dias [3-7] vs. 5 dias [4-7], p = 0,004) foram menores na combina\u00e7\u00e3o inicial SSH+DA em compara\u00e7\u00e3o com o DA padronizado. A mortalidade hospitalar, a hospitaliza\u00e7\u00e3o por IC e a mortalidade por todas as causas foram semelhantes entre os dois grupos.  Conclus\u00e3o  SSH como terapia inicial, quando combinada com DA, pode proporcionar uma diurese segura e eficaz sem prejudicar a fun\u00e7\u00e3o renal na ICAD. Portanto, a SSH pode levar a um menor tempo de interna\u00e7\u00e3o hospitalar para esses pacientes.<\/jats:p>","DOI":"10.36660\/abc.20230818","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T16:04:18Z","timestamp":1721750658000},"source":"Crossref","is-referenced-by-count":0,"title":["O Efeito da Administra\u00e7\u00e3o Precoce de Solu\u00e7\u00e3o Salina Hipert\u00f4nica na Insufici\u00eancia Card\u00edaca Descompensada Aguda"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-6177","authenticated-orcid":false,"given":"Tugce","family":"Colluoglu","sequence":"first","affiliation":[{"name":"Karabuk University,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1947-8998","authenticated-orcid":false,"given":"Tu\u011fba","family":"Kapan\u015fahin","sequence":"additional","affiliation":[{"name":"Karabuk University,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-2939","authenticated-orcid":false,"given":"Melahat Hicran","family":"Aksu","sequence":"additional","affiliation":[{"name":"Karabuk University,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9780-7051","authenticated-orcid":false,"given":"Orhan","family":"\u00d6nalan","sequence":"additional","affiliation":[{"name":"Karabuk University,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-7439","authenticated-orcid":false,"given":"Ye\u015fim","family":"Akin","sequence":"additional","affiliation":[{"name":"Karabuk University,  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