{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:58:46Z","timestamp":1783612726094,"version":"3.55.0"},"reference-count":16,"publisher":"Sociedade Brasileira de Cardiologia","issue":"11","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>RESUMO O fechamento do canal arterial por meio da utiliza\u00e7\u00e3o de inibidores de cicloxigenase (COX), \u00e9 considerado o tratamento de primeira linha da persist\u00eancia do canal arterial hemodinamicamente significativo (PCAHS). Fisiologicamente, as prostaglandinas t\u00eam papel reconhecido na PCA (persist\u00eancia do canal arterial). Reconhecidamente, a efic\u00e1cia e seguran\u00e7a comparativa entre o ibuprofeno e o paracetamol precisa ser determinada para escolha racional da terapia medicamentosa do fechamento do ducto arterial (DA) em protocolos cl\u00ednicos. O presente estudo tem como objetivo apresentar os aspectos da efic\u00e1cia e da seguran\u00e7a terap\u00eautica do paracetamol versus ibuprofeno no tratamento da PCA em rec\u00e9m-nascidos prematuros. Procedeu-se a revis\u00e3o sistem\u00e1tica da literatura, seguindo as recomenda\u00e7\u00f5es do protocolo PRISMA, utilizando as bases de dados Medline, Pubmed, LILACS e SciELO. Foram inclu\u00eddos estudos dos \u00faltimos 10 anos (2013-2023), os quais analisaram a efic\u00e1cia e\/ou seguran\u00e7a do paracetamol em compara\u00e7\u00e3o ao ibuprofeno em rec\u00e9m-nascidos com diagn\u00f3stico de PCA. Foram selecionados para an\u00e1lise 8 ensaios cl\u00ednicos randomizados (ECRs), resultando em um tamanho amostral de 781 neonatos com PCA tratados com paracetamol ou com ibuprofeno. A efic\u00e1cia do paracetamol para o fechamento do DA \u00e9 compar\u00e1vel ao ibuprofeno. N\u00e3o h\u00e1 diferen\u00e7a estatisticamente significativa na incid\u00eancia de efeitos adversos relacionadas entre os dois medicamentos na maioria dos estudos. H\u00e1 equival\u00eancia na efic\u00e1cia e na seguran\u00e7a do ibuprofeno e paracetamol para promover o fechamento do DA em rec\u00e9m-nascidos prematuros com PCAHS.<\/jats:p>","DOI":"10.36660\/abc.20240058","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T10:22:42Z","timestamp":1734430962000},"source":"Crossref","is-referenced-by-count":4,"title":["Efic\u00e1cia e Seguran\u00e7a Terap\u00eautica do Paracetamol versus Ibuprofeno na Persist\u00eancia do Ducto Arterial em Rec\u00e9m-Nascidos: Uma Revis\u00e3o Sistem\u00e1tica"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5681-5669","authenticated-orcid":false,"given":"Halecy Davidson Sousa","family":"da Silva","sequence":"first","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eryvelton de Souza","family":"Franco","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Caroline de Almeida Sousa","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Bernadete de Sousa","family":"Maia","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22636","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000526318","article-title":"Comparison of Various Pharmacologic Agents in the Management of Hemodynamically Significant Patent Ductus Arteriosus in Preterm: A Network Meta-analysis and Risk-benefit Analysis","volume":"7","author":"Eursiriwan S","year":"2022","journal-title":"Biomed Hub"},{"issue":"12","key":"ref2","first-page":"CD013278","article-title":"Early Treatment versus Expectant Management of Hemodynamically Significant Patent Ductus Arteriosus for Preterm Infants","volume":"12","author":"Mitra S","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1542\/peds.2008-2433","article-title":"Does Ibuprofen Increase Neonatal Hyperbilirubinemia?","volume":"124","author":"Zecca E","year":"2009","journal-title":"Pediatrics"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1651-2227.2008.01007.x","article-title":"Total Serum Bilirubin Levels During Cyclooxygenase Inhibitor Treatment for Patent Ductus Arteriosus in Preterm Infants","volume":"98","author":"Rheinlaender C","year":"2009","journal-title":"Acta Paediatr"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1080\/17425255.2018.1492550","article-title":"The Dark Side of Ibuprofen in the Treatment of Patent Ductus Arteriosus: Could Paracetamol be the Solution?","volume":"14","author":"Cuzzolin L","year":"2018","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ihj.2020.05.012","article-title":"The Efficacy and Safety of Oral Paracetamol versus Oral Ibuprofen for Patent Ductus Arteriosus Closure in Preterm Neonates - 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