{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:19Z","timestamp":1772253139424,"version":"3.50.1"},"reference-count":32,"publisher":"Sociedade Brasileira de Cardiologia","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  H\u00e1 uma falha em se identificar pacientes com insufici\u00eancia card\u00edaca (IC) com um risco aumentado de hospitaliza\u00e7\u00e3o e morte. O Fator de Diferencia\u00e7\u00e3o de Crescimento-15 (GDF-15), um biomarcador associado com inflama\u00e7\u00e3o e estresse oxidativo, surge como um candidato associado a doen\u00e7a renal e cardiovascular. Valores baixos de taxa de filtra\u00e7\u00e3o glomerular estimada (TFGe), S\u00f3dio Urin\u00e1rio (NaU), e valores altos da rela\u00e7\u00e3o albumina\/creatinina urin\u00e1ria s\u00e3o marcadores renais j\u00e1 associados com um alto risco de interna\u00e7\u00e3o hospitalar e mortalidade.  Objetivos  Avaliar a rela\u00e7\u00e3o entre GDF-15 e marcadores renais em pacientes com IC cr\u00f4nica.  M\u00e9todos  Inclu\u00edmos 87 pacientes consecutivos com IC sintom\u00e1tica e fra\u00e7\u00e3o de eje\u00e7\u00e3o do ventr\u00edculo esquerdo reduzida (FEVE &lt;40%), FEVE levemente reduzida (40-49%) ou FEVE melhorada (50%, mas &lt;50% anteriormente) em um hospital universit\u00e1rio. Comparamos as associa\u00e7\u00f5es do GDF-15 e a fra\u00e7\u00e3o N-terminal do pro-pept\u00eddeo natriur\u00e9tico do tipo B (NT-proBNP) com marcadores renais, usando testes de correla\u00e7\u00e3o e an\u00e1lise de regress\u00e3o m\u00faltipla com n\u00edvel de signific\u00e2ncia de 5%.  Resultados  o GDF-15 e o NT-proBNP apresentaram correla\u00e7\u00f5es negativas fracas a moderadas com NaU (r=-0,362; p=0,007; r=-0,334; p=0,014, respectivamente) e TFGe (r=-0,385; p=0,0002; r=-0,346; p=0001, respectivamente). GDF-15, idade, hipertens\u00e3o e NT-proBNP foram independentemente associados com TFGe na an\u00e1lise de regress\u00e3o m\u00faltipla (total, R2=0,30). Somente o GDF-15 se associou independentemente com NaU (R2=0,45).  Conclus\u00f5es  Nesses pacientes cr\u00f4nicos com IC, o GDF-15 correlaciona-se melhor com marcadores de disfun\u00e7\u00e3o renal que o NT-proBNP. Uma vez que o valor progn\u00f3stico dos marcadores renais est\u00e1 bem estabelecido, esses achados refor\u00e7am o papel progn\u00f3stico do GDF-15 na IC cr\u00f4nica.<\/jats:p>","DOI":"10.36660\/abc.20240153","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T10:32:46Z","timestamp":1744885966000},"source":"Crossref","is-referenced-by-count":0,"title":["Correla\u00e7\u00e3o do Fator de Diferencia\u00e7\u00e3o de Crescimento-15 com Marcadores Urin\u00e1rios em Pacientes com Insufici\u00eancia Card\u00edaca Cr\u00f4nica"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4204-7598","authenticated-orcid":false,"given":"Gustavo Rodolfo","family":"Moreira","sequence":"first","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7432-576X","authenticated-orcid":false,"given":"Diane Xavier","family":"\u00c1vila","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-2339","authenticated-orcid":false,"given":"Angelo Michele Di","family":"Candia","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria Depes","family":"Scaramussa","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto","family":"Villacorta","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025,3]]},"reference":[{"key":"ref1","series-title":"Braunwald's Heart Disease E-Book: A Textbook of Cardiovascular 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