{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:19Z","timestamp":1772253139509,"version":"3.50.1"},"reference-count":12,"publisher":"Sociedade Brasileira de Cardiologia","issue":"11","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  A glicog\u00eanio sintase quinase 3\u03b2 (GSK3\u03b2) \u00e9 uma enzima que tem pap\u00e9is na patog\u00eanese da insufici\u00eancia card\u00edaca (IC). Tentamos revelar os n\u00edveis s\u00e9ricos de GSK3\u03b2 em tipos de IC.  Objetivos  Neste estudo, avaliamos os n\u00edveis s\u00e9ricos de GSK3\u03b2 em pacientes com IC. Al\u00e9m disso, tentamos elucidar qualquer poss\u00edvel rela\u00e7\u00e3o entre os n\u00edveis s\u00e9ricos de GSK3\u03b2 e a gravidade da doen\u00e7a entre tr\u00eas tipos diferentes de pacientes com IC.  M\u00e9todos  Realizamos um estudo prospectivo e inscrevemos 112 pacientes: 50 pacientes no grupo IC com fra\u00e7\u00e3o de eje\u00e7\u00e3o preservada (ICFEp), 30 pacientes no grupo IC com FE levemente reduzida (ICFEmr) e 32 pacientes no grupo IC com FE reduzida (ICFEr). Tamb\u00e9m avaliamos 50 controles saud\u00e1veis. Exames ecocardiogr\u00e1ficos foram realizados. Medimos a GSK-3\u03b2 s\u00e9rica e o pept\u00eddeo natriur\u00e9tico tipo B N-terminal (NT-proBNP). Medimos os n\u00edveis de prote\u00edna C-reativa altamente sens\u00edvel (PCR-as) e calculamos a raz\u00e3o neutr\u00f3filo-linf\u00f3cito (NLR) e a raz\u00e3o plaquetas-linf\u00f3citos (PLR) a partir da contagem do hemograma. A signific\u00e2ncia estat\u00edstica aceita foi p &lt; 0,05.  Resultados  Os n\u00edveis s\u00e9ricos de GSK3\u03b2 foram significativamente maiores entre pacientes com IC em compara\u00e7\u00e3o com controles saud\u00e1veis (n\u00edveis medianos de GSK3\u03b2; 117,26 (45,39 -223,85) vs 13,91 (5,6 -23,3) ng\/mL, p &lt; 0,001). Al\u00e9m disso, os n\u00edveis de GSK3\u03b2 foram maiores entre pacientes com ICFEp e menores entre pacientes com ICFEr; 236,44 (132,89 -432) vs. 38,72 (23,15-67,31) ng\/mL, respectivamente (p &lt; 0,001). Os n\u00edveis medianos de NT-proBNP, como esperado, foram significativamente maiores entre pacientes com IC em compara\u00e7\u00e3o com controles saud\u00e1veis (660 (291 -1000) vs. 92 (78 -102) pg\/mL, p&lt;0,001). Como um marcador de inflama\u00e7\u00e3o sist\u00eamica, os valores de hsCRP, NLR e PLR n\u00e3o diferiram significativamente entre pacientes com IC e controles. Conclus\u00e3o: Os n\u00edveis de GSK3\u03b2 foram significativamente maiores entre pacientes com IC. Al\u00e9m disso, \u00e0 medida que a fra\u00e7\u00e3o de eje\u00e7\u00e3o diminui, os n\u00edveis de GSK3\u03b2 tamb\u00e9m se reduzem, provavelmente como um mecanismo de prote\u00e7\u00e3o para evitar mais apoptose e morte de mi\u00f3citos.<\/jats:p>","DOI":"10.36660\/abc.20240155","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T09:28:56Z","timestamp":1732872536000},"source":"Crossref","is-referenced-by-count":0,"title":["Determina\u00e7\u00e3o dos N\u00edveis S\u00e9ricos de Glicog\u00eanio Sintase 3 Beta em Pacientes com Insufici\u00eancia Card\u00edaca, um Novo Marcador para Diagn\u00f3stico e Defini\u00e7\u00e3o da Gravidade da Doen\u00e7a?"],"prefix":"10.36660","volume":"121","author":[{"given":"Gokhan","family":"Altunbas","sequence":"first","affiliation":[{"name":"Gaziantep University,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7081-5799","authenticated-orcid":false,"given":"Mehmet","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Gaziantep University,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veysel","family":"Duzen","sequence":"additional","affiliation":[{"name":"Gaziantep University,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin Erdem","family":"Kaya","sequence":"additional","affiliation":[{"name":"Gaziantep City Hospital,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-3267","authenticated-orcid":false,"given":"Hafize Gokce","family":"Gokdeniz","sequence":"additional","affiliation":[{"name":"Hatay Dortyol State Hospital,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-3148","authenticated-orcid":false,"given":"Seyithan","family":"Taysi","sequence":"additional","affiliation":[{"name":"Gaziantep University,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/eurheartj\/ehab892","article-title":"European Society of Cardiology: Cardiovascular Disease Statistics 2021","volume":"43","author":"Timmis A","year":"2022","journal-title":"Eur Heart J"},{"issue":"36","key":"ref2","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure","volume":"42","author":"McDonagh TA","year":"2021","journal-title":"Eur Heart J"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/CIRCRESAHA.109.197996","article-title":"Role of Glycogen Synthase Kinase-3beta in Cardioprotection","volume":"104","author":"Juhaszova M","year":"2009","journal-title":"Circ Res"},{"issue":"15","key":"ref4","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.2174\/1389450122666210114095307","article-title":"GSK-3 Inhibitors: A New Class of Drugs for Alzheimer's Disease Treatment","volume":"22","author":"Pal D","year":"2021","journal-title":"Curr Drug Targets"},{"issue":"Pt 7","key":"ref5","doi-asserted-by":"crossref","first-page":"127375","DOI":"10.1016\/j.ijbiomac.2023.127375","article-title":"A Review of Glycogen Synthase Kinase-3 (GSK3) Inhibitors for Cancers Therapies","volume":"253","author":"Thapa R","year":"2023","journal-title":"Int J Biol Macromol"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s10741-020-09961-9","article-title":"Crosstalk between GSK-3\u00df-Actuated Molecular Cascades and Myocardial Physiology","volume":"26","author":"Sharma AK","year":"2021","journal-title":"Heart Fail Rev"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh SF","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S137","DOI":"10.1038\/sj.bjp.0707659","article-title":"Glycogen Synthase Kinase 3 (GSK3) in the Heart: A Point of Integration in Hypertrophic Signalling and a Therapeutic Target? 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