{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:51Z","timestamp":1772253231518,"version":"3.50.1"},"reference-count":38,"publisher":"Sociedade Brasileira de Cardiologia","issue":"10","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  A hipertrofia card\u00edaca patol\u00f3gica (HC) sustentada \u00e9 um fator de risco independente para aumento da incid\u00eancia e mortalidade de eventos cardiovasculares.  Objetivos  Esta pesquisa foi projetada para desvendar o papel do RNA n\u00e3o codificante longo (LncRNA) CCAT2 na progress\u00e3o da HC.  M\u00e9todos  Procedimentos de constri\u00e7\u00e3o a\u00f3rtica transversal (TAC) foram conduzidos para construir um modelo de HC in vivo induzido por sobrecarga de press\u00e3o. O tratamento com angiotensina II (Ang II) foi utilizado para induzir c\u00e9lulas hipertr\u00f3ficas de cardiomi\u00f3citos de rato H9c2.  Resultados  Os resultados in vivo mostraram que o silenciamento de CCAT2 reduziu a \u00e1rea de superf\u00edcie dos cardiomi\u00f3citos, aliviou a fibrose card\u00edaca e diminuiu os n\u00edveis de \u03b2-MHC, ANP e BNP em modelos de camundongos HC. Os resultados in vitro revelaram que o knockdown de CCAT2 reduziu a \u00e1rea de superf\u00edcie celular e atenuou os n\u00edveis de \u03b2-MHC, ANP e BNP em c\u00e9lulas hipertr\u00f3ficas H9c2. Al\u00e9m disso, o silenciamento de CCAT2 diminuiu os n\u00edveis de \u03b2-catenina ativa, GSK-3\u03b2 fosforilada e genes alvo Wnt (c-Myc, ciclinaD1 e c-Jun) em camundongos HC e c\u00e9lulas H9c2 hipertr\u00f3ficas. \u00c9 importante ressaltar que o tratamento com o ativador da via Wnt \/ \u03b2-catenina LiCl reverteu a supress\u00e3o do knockdown de CCAT2 na \u00e1rea de superf\u00edcie celular H9c2 e nos n\u00edveis de MHC, ANP e BNP.  Conclus\u00f5es  Coletivamente, o silenciamento do CCAT2 desempenha um papel protetor contra a HC atrav\u00e9s da inativa\u00e7\u00e3o da sinaliza\u00e7\u00e3o Wnt\/\u03b2-catenina, o que sugere que o CCAT2 pode se tornar um alvo terap\u00eautico promissor para o HC.<\/jats:p>","DOI":"10.36660\/abc.20240181","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T10:46:10Z","timestamp":1732013170000},"source":"Crossref","is-referenced-by-count":0,"title":["O Knockdown de LncRNA CCAT2 Alivia a Sobrecarga de Press\u00e3o ou a Hipertrofia Card\u00edaca Induzida por Ang II por Meio da Interrup\u00e7\u00e3o da Sinaliza\u00e7\u00e3o Wnt\/\u03b2-catenina"],"prefix":"10.36660","volume":"121","author":[{"given":"Xiaojun","family":"Zhang","sequence":"first","affiliation":[{"name":"Shangdong University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shangdong University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Wu","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganzhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0938-9584","authenticated-orcid":false,"given":"Meizhen","family":"Dong","sequence":"additional","affiliation":[{"name":"Shangdong University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref1","series-title":"Adv Exp Med Biol","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-3-319-55330-6_11","volume-title":"Mitochondria and Cardiac Hypertrophy","volume":"982","author":"Facundo HDTF","year":"2017"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1139\/cjpp-2019-0566","article-title":"Mechanisms for the Transition from Physiological to Pathological 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