{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:32:36Z","timestamp":1786523556994,"version":"build-2736575974"},"reference-count":42,"publisher":"Sociedade Brasileira de Cardiologia","issue":"10","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo A Hipereosinofilia (HE) \u00e9 definida como uma contagem de eosin\u00f3filos superior a 1500 c\u00e9lulas\/microL no sangue perif\u00e9rico em dois exames, realizados com intervalo m\u00ednimo de um m\u00eas e\/ou confirma\u00e7\u00e3o anatomopatol\u00f3gica de HE, com eosin\u00f3filos compreendendo mais de 20% de todas as c\u00e9lulas nucleadas da medula \u00f3ssea. A S\u00edndrome hipereosinof\u00edlica (SHE) indica a presen\u00e7a de HE com comprometimento de \u00f3rg\u00e3os por a\u00e7\u00e3o eosinof\u00edlica, podendo ser classificada como prim\u00e1ria (ou neopl\u00e1sica), secund\u00e1ria (ou reativa) e idiop\u00e1tica. O comprometimento card\u00edaco ocorre em at\u00e9 5% dos casos na fase aguda e em 20% na fase cr\u00f4nica da doen\u00e7a, variando de casos oligossintom\u00e1ticos at\u00e9 miocardite aguda fulminante ou cardiomiopatia restritiva cr\u00f4nica (endomiocardite de Loeffler). No entanto, o grau de disfun\u00e7\u00e3o card\u00edaca n\u00e3o se correlaciona diretamente com o grau de eosinofilia. O envolvimento card\u00edaco na SHE ocorre em tr\u00eas fases: necr\u00f3tica inicial, tromb\u00f3tica e necr\u00f3tica final. Pode se manifestar como insufici\u00eancia card\u00edaca, arritmias e fen\u00f4menos tromboemb\u00f3licos. O diagn\u00f3stico de cardiopatia \u00e9 baseado em m\u00e9todos de imagem multimodalidade, com \u00eanfase na import\u00e2ncia do ecocardiograma transtor\u00e1cico (ETT). Em pacientes com janela ac\u00fastica limitada, podem ser utilizados agentes de contraste ultrassonogr\u00e1fico, que permitem melhor visualiza\u00e7\u00e3o das bordas endoc\u00e1rdicas e da regi\u00e3o ventricular apical. T\u00e9cnicas para an\u00e1lise da deforma\u00e7\u00e3o mioc\u00e1rdica podem evidenciar redu\u00e7\u00e3o do strain em segmentos apicais e preserva\u00e7\u00e3o nos demais segmentos (reverse apical sparing). A resson\u00e2ncia magn\u00e9tica card\u00edaca permite a caracteriza\u00e7\u00e3o do realce tardio subendoc\u00e1rdico de gadol\u00ednio, e a bi\u00f3psia endomioc\u00e1rdica \u00e9 considerada o padr\u00e3o ouro no diagn\u00f3stico de cardiopatia. O tratamento \u00e9 baseado na etiologia da SHE.<\/jats:p>","DOI":"10.36660\/abc.20240190","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T08:41:57Z","timestamp":1732869717000},"source":"Crossref","is-referenced-by-count":1,"title":["Anormalidades Card\u00edacas nas S\u00edndromes Hipereosinof\u00edlicas"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9236-3815","authenticated-orcid":false,"given":"Viviane Tiemi","family":"Hotta","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil; Fleury Medicina e Sa\u00fade,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0241-5535","authenticated-orcid":false,"given":"Rafael Ruas","family":"Nastari","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gard\u00eania da Silva Lobo","family":"Oishi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil; Fleury Medicina e Sa\u00fade,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1343-7262","authenticated-orcid":false,"given":"Alexandre Eiji","family":"Kayano","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil; Hospital Israelita Albert Einstein,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Alzira Gonzales","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiza Gon\u00e7alves","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Olga","family":"Mocumbi","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade,  Mo\u00e7ambique; Universidade Eduardo Mondlane,  Mo\u00e7ambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Salles","family":"Seguro","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-1792","authenticated-orcid":false,"given":"Jos\u00e9 Eduardo","family":"Krieger","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-8805","authenticated-orcid":false,"given":"F\u00e1bio","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Maria Cury","family":"Salemi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil; 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