{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:19Z","timestamp":1772253139536,"version":"3.50.1"},"reference-count":26,"publisher":"Sociedade Brasileira de Cardiologia","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  O polimorfismo de Inser\u00e7\u00e3o\/Dele\u00e7\u00e3o (I\/D) da enzima conversora de angiotensina (ECA) (rs4340) est\u00e1 associado \u00e0 patog\u00eanese da insufici\u00eancia card\u00edaca (IC). Esse polimorfismo pode contribuir para uma maior propens\u00e3o \u00e0 IC grave e ao excesso de peso.  Objetivo  Avaliar a adiposidade, a fun\u00e7\u00e3o card\u00edaca e sua associa\u00e7\u00e3o com o polimorfismo I\/D da ECA em pacientes com IC.  M\u00e9todos  Estudo transversal com indiv\u00edduos ambulatoriais com idade \u226518 anos diagnosticados com IC. A an\u00e1lise gen\u00e9tica foi realizada por rea\u00e7\u00e3o em cadeia da polimerase seguida de eletroforese em gel de agarose. A fra\u00e7\u00e3o de eje\u00e7\u00e3o do ventr\u00edculo esquerdo (FEVE) foi determinada por ecocardiografia. O estado nutricional foi avaliado pelo \u00edndice de massa corporal, enquanto a adiposidade foi avaliada pela an\u00e1lise de Bioimped\u00e2ncia el\u00e9trica (BIA), circunfer\u00eancia da cintura, raz\u00e3o cintura-quadril e raz\u00e3o cintura-estatura. O n\u00edvel de signific\u00e2ncia adotado foi de 5% (p &lt; 0,05).  Resultados  Setenta e um indiv\u00edduos foram inclu\u00eddos, com m\u00e9dia de idade de 55,8 \u00b1 13,0 anos, predominantemente do sexo masculino (66,2%), com classe funcional I e II (90,9%) e FEVE mediana de 30% (24-40). A preval\u00eancia de sobrepeso foi de 38%, obesidade classe I foi de 23,9% e obesidade classe II e III foi de 12,7%, com 50,7% apresentando excesso de adiposidade conforme avaliado pela BIA. Um total de 88 alelos D e 54 alelos I do gene da ECA foram identificados. Em rela\u00e7\u00e3o aos gen\u00f3tipos da ECA, 38,1% eram DD, 47,8% eram ID e 14,1% eram II. Na an\u00e1lise multivariada, o alelo D (gen\u00f3tipos DD+ID versus II) foi associado \u00e0 FEVE (RP de 0,995; IC de 95% 0,991\u20131,000; p = 0,048) e \u00e0 etiologia da IC (cardiomiopatia dilatada: RP 1,283; IC de 95% 1,039\u20131,583; p = 0,021). Nenhuma associa\u00e7\u00e3o independente foi encontrada com a adiposidade.  Conclus\u00e3o  A presen\u00e7a do alelo D do polimorfismo da ECA est\u00e1 associada \u00e0 FEVE e \u00e0 etiologia da IC. Apesar da preval\u00eancia do sobrepeso na amostra, n\u00e3o foram encontradas associa\u00e7\u00f5es independentes.<\/jats:p>","DOI":"10.36660\/abc.20240204","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T08:58:36Z","timestamp":1737449916000},"source":"Crossref","is-referenced-by-count":0,"title":["Influ\u00eancia do Polimorfismo de Inser\u00e7\u00e3o\/Dele\u00e7\u00e3o do Gene da Enzima Conversora de Angiotensina na Adiposidade e na Fun\u00e7\u00e3o Card\u00edaca em Pacientes com Insufici\u00eancia Card\u00edaca"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7024-0701","authenticated-orcid":false,"given":"Marla Darlene Machado","family":"Vale","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil; Hospital de Cl\u00ednicas de Porto Alegre,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-0599","authenticated-orcid":false,"given":"\u00c9dina Caroline Ternus","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brasil; Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid da Silveira","family":"Knobloch","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida Vanessa Doederlein","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brasil; Universidade Federal do Rio Grande do Sul,  Brasil; Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Sperb-Ludwig","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil; Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-4334","authenticated-orcid":false,"given":"Gabriela Corr\u00eaa","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil; 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