{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:12Z","timestamp":1772253192019,"version":"3.50.1"},"reference-count":38,"publisher":"Sociedade Brasileira de Cardiologia","issue":"8","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento: A doen\u00e7a renal cr\u00f4nica (DRC) est\u00e1 associada \u00e0 maior preval\u00eancia de valvopatias e \u00e0 maior mortalidade por causas cardiovasculares. Aspectos que exercem influ\u00eancia sobre a g\u00eanese da calcifica\u00e7\u00e3o valvar card\u00edaca (CVC) nestes pacientes n\u00e3o est\u00e3o bem definidos.  Objetivo: Determinar fatores de risco \u00e0 calcifica\u00e7\u00e3o valvar em pacientes com DRC.  M\u00e9todos: Revis\u00e3o sistem\u00e1tica baseada no PRISMA, que incluiu estudos observacionais avaliando a associa\u00e7\u00e3o entre aspectos cl\u00ednicos e laboratoriais e CVC em pacientes com DRC, realizando ou n\u00e3o hemodi\u00e1lise ou di\u00e1lise peritoneal. Os artigos foram obtidos em bases de dados (MEDLINE; SCIELO; CENTRAL; EMBASE; LILACS\/BVS) e selecionados por dois autores de forma cega; um terceiro atuou em discrep\u00e2ncias. Coleta e s\u00edntese dos dados foi realizada pela autora principal. Avalia\u00e7\u00e3o da qualidade metodol\u00f3gica e risco de vi\u00e9s embasados no STROBE e Newcastle-Ottawa.  Resultados: Foram encontrados 783 estudos, dos quais 20 foram inclu\u00eddos, englobando 13 314 pacientes em 10 pa\u00edses. Os aspectos mais fortemente associados \u00e0 CVC foram idade &gt; 55 anos, taxa de filtra\u00e7\u00e3o glomerular &lt; 53mL\/min\/1,73m2, terapia renal substitutiva (TRS) &gt; 20 meses, hipoalbuminemia, prote\u00edna C reativa (PCR), n\u00edveis s\u00e9ricos de IL-6, TNF- \u03b1, paratorm\u00f4nio, hiperfosfatemia, hipercalcemia, produto Ca x P e FGF-23 decorrentes do hiperparatireoidismo secund\u00e1rio. Foram estudadas valvas mitral e a\u00f3rtica. N\u00e3o houve diferen\u00e7a entre hemodi\u00e1lise versus di\u00e1lise peritoneal.  Conclus\u00e3o: Idade, TRS, inflama\u00e7\u00e3o cr\u00f4nica e hiperparatireoidismo favorecem a deposi\u00e7\u00e3o de Ca e P nas v\u00e1lvulas, tornando os pacientes com DRC mais suscept\u00edveis \u00e0 CVC. O acompanhamento de tais par\u00e2metros permite oportunidades de preven\u00e7\u00e3o e tratamento.<\/jats:p>","DOI":"10.36660\/abc.20240222","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T15:49:17Z","timestamp":1760456957000},"source":"Crossref","is-referenced-by-count":0,"title":["Preditores Cl\u00ednicos e Laboratoriais do Desenvolvimento de Valvopatias na Doen\u00e7a Renal Cr\u00f4nica: Uma Revis\u00e3o Sistem\u00e1tica"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0671-491X","authenticated-orcid":false,"given":"Hayala Machado Cavalcante","family":"Concei\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lu\u00edsa Vaz","family":"Valois","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick Magalh\u00e3es Silva","family":"Ramos","sequence":"additional","affiliation":[{"name":"Universidade Salvador,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Marice","family":"Ladeia","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.kint.2019.06.025","article-title":"Conference Participants. 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