{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:07Z","timestamp":1772253187027,"version":"3.50.1"},"reference-count":15,"publisher":"Sociedade Brasileira de Cardiologia","issue":"9","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento: Tanto o fondaparinux quanto o acesso radial t\u00eam sido associados a menores taxas de eventos adversos cardiovasculares maiores (MACE) em pacientes com s\u00edndrome coronariana aguda (SCA).  Objetivo: Avaliar a associa\u00e7\u00e3o entre o uso de fondaparinux combinado ao acesso radial e os desfechos cl\u00ednicos.  M\u00e9todos: Foram analisados 956 pacientes internados com SCA e submetidos a estrat\u00e9gia invasiva. O desfecho prim\u00e1rio \u2014 composto por sangramento maior (segundo os crit\u00e9rios do estudo OASIS-5) e MACE \u2014 foi comparado entre os grupos definidos conforme o esquema anticoagulante (fondaparinux ou enoxaparina) e o s\u00edtio de acesso arterial (femoral ou radial). Valores de p &lt; 0,05 foram considerados estatisticamente significativos.  Resultados: A m\u00e9dia de idade da popula\u00e7\u00e3o foi de 65 \u00b1 12,4 anos, sendo que 49,5% apresentavam infarto agudo do mioc\u00e1rdio sem supradesnivelamento do segmento ST (IAMSSST). O uso de fondaparinux + acesso radial foi observado em 366 pacientes. O desfecho prim\u00e1rio ocorreu em 78 pacientes (8,1%), sendo MACE em 50 (5,2%) e sangramento maior em 32 (3,3%). A menor taxa de eventos foi observada no grupo fondaparinux + acesso radial (3,3%), em compara\u00e7\u00e3o com enoxaparina + acesso radial (9,8%), fondaparinux + femoral (8,6%) e enoxaparina + femoral (14,4%) (p &lt; 0,001). Na an\u00e1lise multivariada, o uso de fondaparinux foi associado a uma redu\u00e7\u00e3o de 43% no desfecho prim\u00e1rio (OR 0,57; IC 95% 0,34-0,96; p &lt; 0,05), e o acesso radial foi independentemente associado a uma redu\u00e7\u00e3o de 54% (OR 0,46; IC 95% 0,26-0,83; p = 0,01).  Conclus\u00e3o: A combina\u00e7\u00e3o de fondaparinux com acesso radial foi associada \u00e0s menores taxas de MACE e sangramento maior, quando comparada a cada uma das estrat\u00e9gias isoladamente.<\/jats:p>","DOI":"10.36660\/abc.20240329","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T17:14:11Z","timestamp":1764954851000},"source":"Crossref","is-referenced-by-count":0,"title":["Associa\u00e7\u00e3o entre o Uso de Fondaparinux com Acesso Radial e Desfechos Cl\u00ednicos em Pacientes com S\u00edndrome Coronariana Aguda sem Supradesnivelamento do Segmento ST"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9320-7999","authenticated-orcid":false,"given":"Luiz Eduardo Fonteles","family":"Ritt","sequence":"first","affiliation":[{"name":"Instituto D\u2019Or de Pesquisa e Ensino,  Brasil; Escola Bahiana de Medicina e Sa\u00fade P\u00fablica,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Sahade","family":"Darze","sequence":"additional","affiliation":[{"name":"Instituto D\u2019Or de Pesquisa e Ensino,  Brasil; Escola Bahiana de Medicina e Sa\u00fade P\u00fablica,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1940-4470","authenticated-orcid":false,"given":"Pedro Gabriel Melo de Barros e","family":"Silva","sequence":"additional","affiliation":[{"name":"Hospital Samaritano Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilson Soares","family":"Feitosa-Filho","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Victor Santos Pereira","family":"Ramos","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia A.","family":"Viana","sequence":"additional","affiliation":[{"name":"Instituto D\u2019Or de Pesquisa e Ensino,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Neri","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7028-9258","authenticated-orcid":false,"given":"Emanoela Lima","family":"Freitas","sequence":"additional","affiliation":[{"name":"Instituto D\u2019Or de Pesquisa e Ensino,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Queila Oliveira","family":"Borges","sequence":"additional","affiliation":[{"name":"Instituto D\u2019Or de Pesquisa e Ensino,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano 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