{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:57Z","timestamp":1772253237600,"version":"3.50.1"},"reference-count":28,"publisher":"Sociedade Brasileira de Cardiologia","issue":"10","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  As doen\u00e7as cardiovasculares (DCV) s\u00e3o a principal causa de mortes no mundo. A ades\u00e3o ao tratamento medicamentoso \u00e9 um fator importante no manejo de DCV cr\u00f4nicas, influenciando diretamente a ocorr\u00eancia de desfechos e custos da sa\u00fade.  Objetivos  Esta revis\u00e3o sistem\u00e1tica, apoiada pela Sociedade Brasileira de Cardiologia, tem como objetivo avaliar o impacto da baixa ades\u00e3o aos medicamentos para DCV sobre desfechos cl\u00ednicos cr\u00edticos como morte e eventos cardiovasculares.  M\u00e9todos  Foi realizada uma busca abrangente em quatro bases de dados: Medline, Embase, Lilacs e Cochrane. Foram inclu\u00eddas revis\u00f5es sistem\u00e1ticas e metan\u00e1lises que avaliaram estimativas de risco para ades\u00e3o aos medicamentos cardiovasculares. Quatro revis\u00f5es sistem\u00e1ticas, cada uma incorporando estudos observacionais, foram selecionadas.  Resultados  O aumento na ades\u00e3o aos medicamentos reduz significativamente o risco de eventos cardiovasculares, acidente vascular cerebral (AVC) e morte por todas as causas. Uma melhoria de 20% na ades\u00e3o a medicamentos anti-hipertensivos, hipolipemiantes e outros medicamentos cardiovasculares foi correlacionada com redu\u00e7\u00f5es nos eventos cardiovasculares em 7%, 10% e 9%, respectivamente; AVC em 17%, 13% e 18%; e morte em 12%, 9% e 10%. A certeza das evid\u00eancias foi moderada, sugerindo que esses efeitos provavelmente est\u00e3o presentes. Esses achados enfatizam a necessidade de aumentar a ades\u00e3o aos tratamentos para melhorar os desfechos cl\u00ednicos no manejo das DCV.  Conclus\u00f5es  Evid\u00eancias demonstraram redu\u00e7\u00f5es em morte e desfechos cr\u00edticos, tanto na preven\u00e7\u00e3o prim\u00e1ria quanto na secund\u00e1ria, por meio do controle de condi\u00e7\u00f5es como hipertens\u00e3o e colesterol LDL elevado, assim como benef\u00edcios da terapia antiplaquet\u00e1ria na doen\u00e7a ateroscler\u00f3tica. Mais estudos s\u00e3o necess\u00e1rios para melhor elucidar a rela\u00e7\u00e3o entre a ades\u00e3o aos medicamentos cardiovasculares e a melhora de desfechos cl\u00ednicos cr\u00edticos.<\/jats:p>","DOI":"10.36660\/abc.20240469","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T08:36:56Z","timestamp":1732869416000},"source":"Crossref","is-referenced-by-count":0,"title":["Risco de Desfechos Adversos \u00e0 Sa\u00fade em Pacientes com Baixa Ades\u00e3o ao Tratamento Medicamentoso Cardiovascular: Uma Revis\u00e3o Sistem\u00e1tica"],"prefix":"10.36660","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8171-3920","authenticated-orcid":false,"given":"Marcus Vin\u00edcius Bol\u00edvar","family":"Malachias","sequence":"first","affiliation":[{"name":"FELUMA,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0904-8564","authenticated-orcid":false,"given":"Sergio 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