{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:43Z","timestamp":1772253163844,"version":"3.50.1"},"reference-count":30,"publisher":"Sociedade Brasileira de Cardiologia","issue":"5","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  Valores elevados de press\u00e3o arterial (PA) t\u00eam sido tradicionalmente associados ao risco de doen\u00e7a isqu\u00eamica do cora\u00e7\u00e3o, acidente vascular cerebral, doen\u00e7a renal cr\u00f4nica e mortalidade precoce. A dilata\u00e7\u00e3o mediada por fluxo (FMD) da art\u00e9ria braquial ap\u00f3s a desinsufla\u00e7\u00e3o do manguito tornou-se o par\u00e2metro padr\u00e3o para quantificar a fun\u00e7\u00e3o endotelial, sendo um desfecho substituto \u00fatil em fun\u00e7\u00e3o de sua n\u00e3o invasividade, estreita correla\u00e7\u00e3o com a fun\u00e7\u00e3o endotelial coronariana e associa\u00e7\u00e3o com a incid\u00eancia de eventos coronarianos em longo prazo.  Objetivos  Testar hip\u00f3teses de correla\u00e7\u00e3o entre a FMD e diversos par\u00e2metros sangu\u00edneos e comparar os par\u00e2metros entre grupos com a FMD alterada e n\u00e3o alterada e entre hipertensos dos grupos hipertens\u00e3o arterial resistente (HAR e n\u00e3o HAR).  M\u00e9todos  Setenta e dois volunt\u00e1rios de um ambulat\u00f3rio de refer\u00eancia em Hipertens\u00e3o Arterial foram inclu\u00eddos neste estudo transversal prospectivo, no qual foram comparadas diversas vari\u00e1veis mensuradas nos pacientes, entre os grupos FMD alterada (n = 38) e n\u00e3o alterada (n = 34), e tamb\u00e9m entre os grupos HAR (n = 49) e n\u00e3o HAR (n = 23). Investigamos tamb\u00e9m quais vari\u00e1veis explicariam a FMD. As an\u00e1lises estat\u00edsticas foram conduzidas por meio de m\u00e9todos param\u00e9tricos quando os pressupostos foram atendidos e n\u00e3o param\u00e9tricos quando estes n\u00e3o foram atendidos. O n\u00edvel de signific\u00e2ncia adotado nas an\u00e1lises estat\u00edsticas foi de 5%.  Resultados  Os resultados mostraram uma correla\u00e7\u00e3o positiva significativa entre FMD e LDL (p = 0,204, p = 0,042) e entre FMD e triglicer\u00eddeos (p = 0,247, p = 0,037). Hemoglobina glicada foi maior no grupo HAR (p = 0,020), pot\u00e1ssio foi maior no grupo n\u00e3o HAR (p = 0,029) e prote\u00edna C reativa foi maior no grupo HAR (p = 0,04). N\u00e3o houve diferen\u00e7as estat\u00edsticas significativas para as demais compara\u00e7\u00f5es.  Conclus\u00f5es  O LDL e os triglicer\u00eddeos s\u00e3o preditores da FMD e os grupos HAR e n\u00e3o HAR diferem quanto \u00e0 quantidade de pot\u00e1ssio, prote\u00edna C e hemoglobina glicada. Os grupos de FMD alterada e n\u00e3o alterada diferem somente em rela\u00e7\u00e3o aos triglicer\u00eddeos.<\/jats:p>","DOI":"10.36660\/abc.20240533","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T15:03:46Z","timestamp":1748876626000},"source":"Crossref","is-referenced-by-count":0,"title":["Fun\u00e7\u00e3o Endotelial por Dilata\u00e7\u00e3o Mediada por Fluxo (FMD) na Art\u00e9ria Braquial em Hipertensos"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3870-6746","authenticated-orcid":false,"given":"Elaine Alves Santos","family":"Tessier","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1115-688X","authenticated-orcid":false,"given":"Carla","family":"Daltro","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Martins","family":"Netto","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glauco Moniz de Arag\u00e3o","family":"Doria","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Jimena Gutierrez","family":"Peredo","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-0552","authenticated-orcid":false,"given":"Fabio","family":"Bulh\u00f5es","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2161-3696","authenticated-orcid":false,"given":"Roque","family":"Aras","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan A.","family":"Harris","sequence":"additional","affiliation":[{"name":"Augusta University,  EUA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"9349","key":"ref1","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-Specific Relevance of Usual Blood Pressure to Vascular Mortality: A Meta-Analysis of Individual Data for One Million Adults in 61 Prospective Studies","volume":"360","author":"Lewington S","year":"2002","journal-title":"Lancet"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/HYPERTENSIONAHA.117.10662","article-title":"Spironolactone versus Clonidine as a Fourth-Drug Therapy for Resistant Hypertension: The ReHOT Randomized Study (Resistant Hypertension Optimal Treatment)","volume":"71","author":"Krieger EM","year":"2018","journal-title":"Hypertension"},{"issue":"3","key":"ref3","first-page":"516","article-title":"Brazilian Guidelines of Hypertension - 2020","volume":"116","author":"Barroso WKS","year":"2021","journal-title":"Arq Bras Cardiol"},{"issue":"3","key":"ref4","first-page":"576","article-title":"Brazilian Position Statement on Resistant Hypertension - 2020","volume":"114","author":"Yugar-Toledo JC","year":"2020","journal-title":"Arq Bras Cardiol"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1161\/HYP.0000000000000084","article-title":"Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement from the American Heart Association","volume":"72","author":"Carey RM","year":"2018","journal-title":"Hypertension"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1253\/circj.CJ-09-0534","article-title":"Non-Invasive Vascular Function Tests: Their Pathophysiological Background and Clinical Application","volume":"74","author":"Tomiyama H","year":"2010","journal-title":"Circ J"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/01.CIR.95.8.2007","article-title":"Effect of Single-Drug Therapy on Reduction of Left Ventricular Mass in Mild to Moderate Hypertension: Comparison of Six Antihypertensive Agents. 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