{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:47:28Z","timestamp":1791586048082,"version":"4.3.4"},"reference-count":26,"publisher":"Sociedade Brasileira de Cardiologia","issue":"5","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamentos  Apesar de as caracter\u00edsticas cl\u00ednicas da Cardiomiopatia Chag\u00e1sica Cr\u00f4nica (CCC) estarem bem estabelecidas, os dados cl\u00ednicos sobre os pacientes s\u00e3o escassos.  Objetivos  Esta an\u00e1lise relata os resultados do I Registro Brasileiro de Insufici\u00eancia Card\u00edaca (BREATHE) avaliando as caracter\u00edsticas basais e desfechos cl\u00ednicos de pacientes com insufici\u00eancia card\u00edaca aguda secund\u00e1ria \u00e0 CCC.  M\u00e9todos  O BREATHE incluiu 3013 pacientes adultos internados com insufici\u00eancia card\u00edaca aguda. N\u00f3s analisamos comparativamente 261 (8,7%) pacientes com CCC e 2752 (91,3%) pacientes com outras etiologias. Dados cl\u00ednicos e demogr\u00e1ficos, informa\u00e7\u00f5es da estrutura e da fun\u00e7\u00e3o card\u00edaca no ecocardiograma e desfechos durante a interna\u00e7\u00e3o hospitalar e ap\u00f3s a alta foram avaliados em ambos os grupos. Testes univariados e multivariados foram realizados, e um p-valor &lt; 0,05 foi considerado estatisticamente significativo.  Resultados  Pacientes com CCC apresentaram press\u00e3o arterial sist\u00f3lica (108,3 \u00b1 26,1 vs. 128,3 \u00b1 30,3 mmHg, p&lt;0,001) e fra\u00e7\u00e3o de eje\u00e7\u00e3o ventricular esquerda [25,4 (19 \u2013 36)% vs. 37 (27 \u2013 54) %, p&lt;0,001) mais baixas, com taxas mais altas de distens\u00e3o da veia jugular (54,8% vs. 38,9%, p&lt;0,001), hepatomegalia (47,9% vs. 25,6%, p&lt;0,001), e de perfil \u201cfrio e \u00famido\u201d (27,2% vs. 10,6%, p&lt;0,001). Pacientes com CCC apresentaram taxas mais altas do desfecho composto de morte ou transplante card\u00edaco (17,4% vs. 11,1%, p=0,004), e incid\u00eancia cumulativa mais alta de morte ap\u00f3s tr\u00eas meses (16,5% vs. 10,8%, p=0,017), seis meses (25,3% vs. 17,2%, p=0,006), e 12 meses (39,4% vs. 26,6%, p&lt;0,001). Al\u00e9m disso, CCC associou-se independentemente com risco de mortalidade em 12 meses, com um odds ratio de 2,02 (IC95%: 1,47-2,77).  Conclus\u00e3o  Em compara\u00e7\u00e3o a outras etiologias, os pacientes com CCC internados por insufici\u00eancia card\u00edaca aguda apresentaram um perfil de maior risco que foi associado com um pior desfecho durante a interna\u00e7\u00e3o hospitalar e ap\u00f3s a alta.<\/jats:p>","DOI":"10.36660\/abc.20240555","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:13:26Z","timestamp":1749633206000},"source":"Crossref","is-referenced-by-count":2,"title":["Insufici\u00eancia Card\u00edaca Aguda em Pacientes com Cardiomiopatia Chag\u00e1sica: Resultados do I Registro Brasileiro de Insufici\u00eancia Card\u00edaca (BREATHE)"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1940-4470","authenticated-orcid":false,"given":"Pedro Gabriel Melo de Barros e","family":"Silva","sequence":"first","affiliation":[{"name":"Hospital do Cora\u00e7\u00e3o,  Brasil; Centro Universit\u00e1rio S\u00e3o Camilo,  Brasil; Brazilian Clinical Research Institute,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-6546","authenticated-orcid":false,"given":"Denilson Campos","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Departamento de Insufici\u00eancia Card\u00edaca,  Brasil; Hospital Copa D\u2019Or,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Delascio","family":"Lopes","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio S\u00e3o Camilo,  Brasil; Duke University School of Medicine,  EUA; UNIFESP,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Faculdade Regional de Medicina de S\u00e3o Jos\u00e9 do Rio Preto,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0393-2546","authenticated-orcid":false,"given":"Aguinaldo F","family":"Freitas Jr","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Vieira","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Distrito Federal,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-199X","authenticated-orcid":false,"given":"Charles","family":"Mady","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabete Silva dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Esteves","family":"Hernandes","sequence":"additional","affiliation":[{"name":"Santa Casa de Votuporanga,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-0459","authenticated-orcid":false,"given":"Maria Alayde Mendon\u00e7a","family":"Rivera","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o David de","family":"Souza Neto","sequence":"additional","affiliation":[{"name":"Hospital de Messejana,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Rabelo","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Bahiana de Cardiologia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Fernandes","family":"Canesin","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio do Norte do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder","family":"Reis","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas Gaspar Viana,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson da Costa","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrado","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Hospital Regional Hans Dieter Schmidt,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Hideo Nakagawa","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital do Cora\u00e7\u00e3o,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella de Andrade","family":"Jesuino","sequence":"additional","affiliation":[{"name":"Hospital do Cora\u00e7\u00e3o,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6557-393X","authenticated-orcid":false,"given":"Luis Eduardo","family":"Rohde","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brasil; Hospital Moinhos de Vento,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia Zytinsky","family":"Moura","sequence":"additional","affiliation":[{"name":"Irmandade Santa Casa de Miseric\u00f3rdia de Curitiba,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Goulart","family":"Marcondes-Braga","sequence":"additional","affiliation":[{"name":"Departamento de Insufici\u00eancia Card\u00edaca,  Brasil; Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-3870","authenticated-orcid":false,"given":"Evandro Tinoco","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Departamento de Insufici\u00eancia Card\u00edaca,  Brasil; Universidade Federal Fluminense,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3739-7702","authenticated-orcid":false,"given":"Jos\u00e9 Albuquerque de","family":"Figueiredo Neto","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2501-302X","authenticated-orcid":false,"given":"Ricardo","family":"Mourilhe-Rocha","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Pedro Ernesto,  Brasil; Complexo Hospitalar Am\u00e9ricas- Vitoria e Samaritano Barra,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5702-210X","authenticated-orcid":false,"given":"Lu\u00eds","family":"Beck-da-Silva","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brasil; Hospital Moinhos de Vento,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9413-3792","authenticated-orcid":false,"given":"Mucio Tavares","family":"Oliveira Junior","sequence":"additional","affiliation":[{"name":"Departamento de Insufici\u00eancia Card\u00edaca,  Brasil; Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-8387","authenticated-orcid":false,"given":"Marcus Vinicius","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"USP,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/trstmh\/trac065","article-title":"Persistence of Trypanosoma Cruzi Vector-Borne Transmission among School-Age Children In The Bolivian Chaco Documented by 24-Month Longitudinal Serosurveillance","volume":"117","author":"Spinicci M","year":"2023","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref2","series-title":"Chagas disease (American trypanosomiasis)","year":"2024"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1093\/cid\/ciaa1148","article-title":"Case-Fatality from Orally-Transmitted Acute Chagas Disease: A Systematic Review and Meta-Analysis","volume":"72","author":"Bruneto EG","year":"2021","journal-title":"Clin Infect Dis"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00059-021-05020-7","article-title":"Neglected Cardiovascular Diseases and their Significance in the Global North","volume":"46","author":"Viljoen CA","year":"2021","journal-title":"Herz"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003540","article-title":"Prevalence of Chagas Disease in Latin-American Migrants Living in Europe: A Systematic Review and Meta-Analysis","volume":"9","author":"Requena-M\u00e9ndez A","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.106.624296","article-title":"Pathogenesis of Chronic Chagas Heart Disease","volume":"115","author":"Marin-Neto JA","year":"2007","journal-title":"Circulation"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jacc.2017.08.004","article-title":"Chronic Chagas Heart Disease Management: From Etiology to Cardiomyopathy Treatment","volume":"70","author":"Bocchi EA","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1016\/j.ijcard.2013.04.015","article-title":"Prognosis of Patients with Chronic Systolic Heart Failure: Chagas Disease versus Systemic Arterial Hypertension","volume":"168","author":"Bestetti RB","year":"2013","journal-title":"Int J Cardiol"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1161\/CIRCHEARTFAILURE.109.882035","article-title":"Beta-Blocker Therapy and Mortality of Patients with Chagas Cardiomyopathy: A Subanalysis of the REMADHE Prospective Trial","volume":"3","author":"Issa VS","year":"2010","journal-title":"Circ Heart Fail"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004361","article-title":"Contemporary Characteristics and Outcomes in Chagasic Heart Failure Compared with Other Nonischemic and Ischemic Cardiomyopathy","volume":"10","author":"Shen L","year":"2017","journal-title":"Circ Heart Fail"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006207","article-title":"Clinical Findings and Prognosis of Patients Hospitalized for Acute Decompensated Heart Failure: Analysis of the Influence of Chagas Etiology and Ventricular Function","volume":"12","author":"Terhoch CB","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijcard.2004.05.025","article-title":"Risk Stratification in a Brazilian Hospital-Based Cohort of 1220 Outpatients with Heart Failure: Role of Chagas' Heart Disease","volume":"102","author":"Freitas HF","year":"2005","journal-title":"Int J Cardiol"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1590\/1806-9282.63.01.57","article-title":"Decompensated Chagasic Heart Failure versus Non-Chagasic Heart Failure at a Tertiary Care Hospital: Clinical Characteristics and Outcomes","volume":"63","author":"Santos LN","year":"2017","journal-title":"Rev Assoc Med Bras"},{"issue":"6","key":"ref14","first-page":"358","article-title":"Why do Patients with Chagasic Cardiomyopathy have Worse Outcomes than Those with Non-Chagasic Cardiomyopathy?","volume":"91","author":"Silva CP","year":"2008","journal-title":"Arq Bras Cardiol"},{"issue":"5","key":"ref15","first-page":"390","article-title":"Rationale and Design: BREATHE Registry--I Brazilian Registry of Heart Failure","volume":"100","year":"2013","journal-title":"Arq Bras Cardiol"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.cardfail.2023.08.014","article-title":"In-Hospital Management and Long-term Clinical Outcomes and Adherence in Patients with Acute Decompensated Heart Failure: Primary Results of the First Brazilian Registry of Heart Failure (BREATHE)","volume":"30","author":"Albuquerque DC","year":"2024","journal-title":"J Card Fail"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/trstmh\/trac068","article-title":"Socio-Epidemiological Factors and Comorbidities associated with Chagas Disease Manifestations in Two Urban Reference Health Care Centres in Rio de Janeiro, Brazil","volume":"117","author":"Portela LF","year":"2023","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/01.STR.0000163104.92943.50","article-title":"Chagasic Cardiomyopathy is Independently associated with Ischemic Stroke in Chagas Disease","volume":"36","author":"Carod-Artal FJ","year":"2005","journal-title":"Stroke"},{"issue":"12","key":"ref19","first-page":"e169","article-title":"Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement from the American Heart Association","volume":"138","author":"Nunes MCP","year":"2018","journal-title":"Circulation"},{"issue":"5","key":"ref20","first-page":"306","article-title":"Prevention Strategies of Cardioembolic Ischemic Stroke in Chagas' Disease","volume":"91","author":"Sousa AS","year":"2008","journal-title":"Arq Bras Cardiol"},{"issue":"10230","key":"ref21","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0140-6736(20)30171-9","article-title":"Chagas Disease: Still a Neglected Emergency?","volume":"395","author":"Lopes RD","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005571","article-title":"Evaluation of Right Ventricular Systolic Function in Chagas Disease Using Cardiac Magnetic Resonance Imaging","volume":"10","author":"Moreira HT","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.echo.2017.01.010","article-title":"Right Ventricular Systolic Dysfunction in Chagas Disease Defined by Speckle-Tracking Echocardiography: A Comparative Study with Cardiac Magnetic Resonance Imaging","volume":"30","author":"Moreira HT","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jacc.2008.05.068","article-title":"Importance of Venous Congestion for Worsening of Renal Function in Advanced Decompensated Heart Failure","volume":"53","author":"Mullens W","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/eurheartj\/ehs332","article-title":"Liver Function Abnormalities, Clinical Profile, and Outcome in Acute Decompensated Heart Failure","volume":"34","author":"Nikolaou M","year":"2013","journal-title":"Eur Heart J"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.cardfail.2017.03.005","article-title":"Risk Prediction Models for Incident Heart Failure: A Systematic Review of Methodology and Model Performance","volume":"23","author":"Sahle BW","year":"2017","journal-title":"J Card Fail"}],"container-title":["Arquivos Brasileiros de Cardiologia"],"original-title":["Acute Heart Failure in Patients with Chagas Cardiomyopathy: Results of the I Brazilian Heart Failure Registry (BREATHE)"],"link":[{"URL":"https:\/\/abccardiol.org\/wp-content\/uploads\/articles_xml\/0066-782x-abc-122-5-e20240555\/0066-782x-abc-122-5-e20240555.x95083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:13:30Z","timestamp":1749633210000},"score":1,"resource":{"primary":{"URL":"https:\/\/abccardiol.org\/article\/insuficiencia-cardiaca-aguda-em-pacientes-com-cardiomiopatia-chagasica-resultados-do-i-registro-brasileiro-de-insuficiencia-cardiaca-breathe\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0066-782X2025000500310"],"URL":"https:\/\/doi.org\/10.36660\/abc.20240555","relation":{"is-translation-of":[{"id-type":"doi","id":"10.36660\/abc.20240555i","asserted-by":"subject"},{"id-type":"doi","id":"10.36660\/abc.20240555i","asserted-by":"object"}]},"ISSN":["1678-4170","0066-782X"],"issn-type":[{"value":"1678-4170","type":"electronic"},{"value":"0066-782X","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20240555"}}