{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:21Z","timestamp":1772253141612,"version":"3.50.1"},"reference-count":36,"publisher":"Sociedade Brasileira de Cardiologia","issue":"5","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  Na regi\u00e3o Amaz\u00f4nica, observou-se um aumento consider\u00e1vel no n\u00famero de casos de doen\u00e7a de Chagas aguda (DCA), resultando em altera\u00e7\u00f5es eletrocardiogr\u00e1ficas e ecocardiogr\u00e1ficas. Os principais mecanismos fisiopatol\u00f3gicos da cardiomiopatia chag\u00e1sica (CC) incluem a disfun\u00e7\u00e3o microvascular, a disfun\u00e7\u00e3o do Sistema Nervoso Aut\u00f4nomo (SNA), a agress\u00e3o direta do parasita e a atividade inflamat\u00f3ria. A doen\u00e7a de Chagas (DC) \u00e9 um \u00f3timo exemplo de cardiomiopatia inflamat\u00f3ria, capaz de influenciar altera\u00e7\u00f5es nos par\u00e2metros metab\u00f3licos e no SNA. H\u00e1 uma escassez de estudos que abordam a medi\u00e7\u00e3o dos n\u00edveis de adipocitocina e insulina em indiv\u00edduos com DCA.  Objetivo  Avaliar os n\u00edveis de adiponectina, leptina e insulina antes e ap\u00f3s o tratamento da DCA com benznidazol e estabelecer correla\u00e7\u00f5es com o SNA e a fun\u00e7\u00e3o card\u00edaca.  M\u00e9todos  Foram inclu\u00eddos 28 indiv\u00edduos, os quais foram divididos em: grupo controle (GC), com 15 indiv\u00edduos, e grupo com DCA, com 13 indiv\u00edduos. Todos os indiv\u00edduos foram submetidos a um ECG padr\u00e3o de 12 deriva\u00e7\u00f5es, ecocardiografia transtor\u00e1cica completa, avalia\u00e7\u00e3o da fun\u00e7\u00e3o auton\u00f4mica e dos n\u00edveis s\u00e9ricos de adiponectina, insulina e leptina. Foi adotado um n\u00edvel de signific\u00e2ncia de 5% (valor de p &lt; 0,05).  Resultados  Os n\u00edveis de insulina foram mais baixos no grupo com DCA em compara\u00e7\u00e3o com o grupo controle, tanto antes quanto ap\u00f3s o tratamento, e apresentaram redu\u00e7\u00e3o na fase p\u00f3s-tratamento em compara\u00e7\u00e3o com a fase pr\u00e9-tratamento. N\u00e3o houve diferen\u00e7a nos n\u00edveis de adipocitocinas, leptina e adiponectina entre os grupos.  Conclus\u00e3o  Os n\u00edveis de insulina foram mais baixos no grupo com DCA em compara\u00e7\u00e3o com o grupo controle, tanto antes quanto ap\u00f3s o tratamento, e apresentaram redu\u00e7\u00e3o na fase p\u00f3s-tratamento em compara\u00e7\u00e3o com a fase pr\u00e9-tratamento. Os n\u00edveis de adipocitocinas e insulina n\u00e3o apresentaram correla\u00e7\u00e3o significativa com os par\u00e2metros de fun\u00e7\u00e3o card\u00edaca e do SNA.<\/jats:p>","DOI":"10.36660\/abc.20240621","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T15:39:08Z","timestamp":1748273948000},"source":"Crossref","is-referenced-by-count":0,"title":["Redu\u00e7\u00e3o dos N\u00edveis de Insulina em Pacientes com Doen\u00e7a de Chagas Aguda na Amaz\u00f4nia Brasileira Tratados com Benznidazol"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8836-345X","authenticated-orcid":false,"given":"Jo\u00e3o Marcos","family":"Barbosa-Ferreira","sequence":"first","affiliation":[{"name":"Universidade do Estado do Amazonas,  Brasil; Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7214-6816","authenticated-orcid":false,"given":"Jessica Vanina","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Gallinaro","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria das Gra\u00e7as Vale","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas,  Brasil; Universidade do Estado do Amazonas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Augusto de Oliveira","family":"Guerra","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-8858","authenticated-orcid":false,"given":"K\u00e1tia do Nascimento","family":"Couceiro","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica Regina Hosannah Silva e","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Martins","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keila Cardoso Barbosa","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2437-2485","authenticated-orcid":false,"given":"Felix Alvarez","family":"Ramires","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara Maria","family":"Ianni","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-199X","authenticated-orcid":false,"given":"Charles","family":"Mady","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-8805","authenticated-orcid":false,"given":"F\u00e1bio","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"975","key":"ref1","first-page":"1","article-title":"Research priorities for Chagas Disease, Human African Trypanosomiasis and Leishmaniasis","year":"2012","journal-title":"World Health Organ Tech Rep Ser"},{"issue":"1-2","key":"ref2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.actatropica.2009.07.019","article-title":"Chagas Disease in Spain, the United States and Other Non-Endemic Countries","volume":"115","author":"Gascon J","year":"2010","journal-title":"Acta Trop"},{"issue":"3","key":"ref3","first-page":"240","article-title":"Cardiac Evaluation in the Acute Phase of Chagas' Disease with Post-Treatment Evolution in Patients Attended in the State of Amazonas, Brazil","volume":"112","author":"Ortiz JV","year":"2019","journal-title":"Arq Bras Cardiol"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.106.624296","article-title":"Pathogenesis of Chronic Chagas Heart Disease","volume":"115","author":"Marin-Neto 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Pharmacol"},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.0000163635.62927.34","article-title":"Adipose Tissue, Inflammation, and Cardiovascular Disease","volume":"96","author":"Berg AH","year":"2005","journal-title":"Circ Res"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1136\/hrt.2005.083345","article-title":"Circulating Adiponectin Concentrations in Patients with Congestive Heart Failure","volume":"92","author":"George J","year":"2006","journal-title":"Heart"},{"issue":"10-11","key":"ref10","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.clinbiochem.2009.02.023","article-title":"Prognostic Value of Increased Adiponectin Plasma Concentrations in Patients with Acute Destabilized Heart Failure","volume":"42","author":"Dieplinger B","year":"2009","journal-title":"Clin Biochem"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1388-9842(02)00177-0","article-title":"Elevated Serum Levels of Leptin and Soluble Leptin Receptor in Patients with Advanced Chronic Heart Failure","volume":"5","author":"Schulze PC","year":"2003","journal-title":"Eur J Heart Fail"},{"issue":"2-3","key":"ref12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0167-5273(00)00397-1","article-title":"Leptin Serum Levels in Cachectic Heart Failure Patients. 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F","year":"2008","journal-title":"Obesity"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.micinf.2011.06.002","article-title":"Evidence for Trypanosoma Cruzi in Adipose Tissue in Human Chronic Chagas Disease","volume":"13","author":"Ferreira AV","year":"2011","journal-title":"Microbes Infect"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1590\/S0074-02762009000900028","article-title":"Chagas Disease, Adipose Tissue and the Metabolic Syndrome","volume":"104","author":"Nagajyothi F","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref18","series-title":"Adv Parasitol","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/B978-0-12-385895-5.00010-4","volume-title":"Adipose Tissue, Diabetes and Chagas Disease","volume":"76","author":"Tanowitz HB","year":"2011"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1590\/S0100-879X2006005000152","article-title":"Leptin Levels in Different Forms of Chagas' Disease","volume":"40","author":"Fernandes F","year":"2007","journal-title":"Braz J Med Biol Res"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131447","article-title":"Dysregulation of Autonomic Nervous System in Chagas' Heart Disease Is Associated with Altered Adipocytokines Levels","volume":"10","author":"Barbosa-Ferreira JM","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"ref21","first-page":"43","article-title":"Pancreatic Neuronal Loss in Chronic Chagas' Disease Patients","volume":"31","author":"Rocha A","year":"1998","journal-title":"Rev Soc Bras Med Trop"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1590\/S0041-87812001000500001","article-title":"Morphologic and Morphometric Evaluation of Pancreatic Islets in Chronic Chagas' Disease","volume":"56","author":"Saldanha JC","year":"2001","journal-title":"Rev Hosp Clin Fac Med Sao Paulo"},{"issue":"2","key":"ref23","first-page":"125","article-title":"Functional and Histopathological Study of the Pancreas in Hamsters (Mesocricetus Auratus) Infected and Reinfected with Trypanosoma Cruzi","volume":"94","author":"Santos VM","year":"2004","journal-title":"Parasitol Res"},{"issue":"11","key":"ref24","first-page":"1187","article-title":"Blood Glucose and Insulin Response to Intravenous Glucose by Patients with Chronic Chagas' Disease and Alcoholism","volume":"26","author":"Oliveira LC","year":"1993","journal-title":"Braz J Med Biol Res"},{"issue":"5","key":"ref25","first-page":"491","article-title":"Heterogenous Insulin Response to an Oral Glucose Load by Patients with the Indeterminate Clinical Form of Chagas' Disease","volume":"26","author":"Guariento ME","year":"1993","journal-title":"Braz J Med Biol Res"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1590\/S1516-31801994000300006","article-title":"Chronotropic and Blood Pressure Response to Oral Glucose Load in Chagas' Disease","volume":"112","author":"Guariento ME","year":"1994","journal-title":"Sao Paulo Med J"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1139\/cjpp-2018-0349","article-title":"Dysregulation of Insulin Levels in Chagas Heart Disease is Associated with Altered Adipocytokine Levels","volume":"97","author":"Dabarian AL","year":"2019","journal-title":"Can J Physiol Pharmacol"},{"issue":"13","key":"ref28","article-title":"Myocardial Injury in Patients with Acute and Subacute Chagas Disease in the Brazilian Amazon Using Cardiovascular Magnetic Resonance","volume":"11","author":"Couceiro KDN","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"ref29","first-page":"225","article-title":"Blood Pressure, Metabolic and Autonomic Responses to Insulin and Intralipid\u00ae Infusion in Chagasic Patients","volume":"98","author":"Silva CC","year":"2012","journal-title":"Arq Bras Cardiol"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.ajpath.2012.11.027","article-title":"Alterations in Glucose Homeostasis in a Murine Model of Chagas Disease","volume":"182","author":"Nagajyothi F","year":"2013","journal-title":"Am J Pathol"},{"issue":"5","key":"ref31","first-page":"489","article-title":"Frequency of Diabetes Mellitus and Hyperglycemia in Chagasic and Non-Chagasic Women","volume":"32","author":"Santos VM","year":"1999","journal-title":"Rev Soc Bras Med Trop"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.cardfail.2011.08.010","article-title":"Dynamics in Insulin Resistance and Plasma Levels of Adipokines in Patients with Acute Decompensated and Chronic Stable Heart Failure","volume":"17","author":"Schulze 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Relationships with Insulin","volume":"19","author":"Leyva F","year":"1998","journal-title":"Eur Heart J"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1445-5994.2009.02042.x","article-title":"Change of Insulin Sensitivity in Hepatitis C Patients with Normal Insulin Sensitivity: A 5-Year Prospective Follow-Up Study Variation of Insulin Sensitivity in HCV Patients","volume":"40","author":"Park SK","year":"2010","journal-title":"Intern Med J"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.cmet.2021.05.013","article-title":"SARS-CoV-2 Infects Human Pancreatic \u00df Cells and Elicits \u00df Cell Impairment","volume":"33","author":"Wu CT","year":"2021","journal-title":"Cell Metab"},{"issue":"1","key":"ref36","article-title":"Infection with SARS-CoV-2 Can Cause Pancreatic Impairment","volume":"9","author":"Deng W","year":"2024","journal-title":"Signal Transduct Target Ther"}],"container-title":["Arquivos Brasileiros de Cardiologia"],"original-title":["Decreased Insulin Levels in Patients with Acute Chagas Disease from Brazilian Amazon treated with Benznidazole"],"link":[{"URL":"https:\/\/abccardiol.org\/wp-content\/uploads\/articles_xml\/0066-782x-abc-122-5-e20240621\/0066-782x-abc-122-5-e20240621.x95083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T15:39:14Z","timestamp":1748273954000},"score":1,"resource":{"primary":{"URL":"https:\/\/abccardiol.org\/article\/reducao-dos-niveis-de-insulina-em-pacientes-com-doenca-de-chagas-aguda-na-amazonia-brasileira-tratados-com-benznidazol\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0066-782X2025000500304"],"URL":"https:\/\/doi.org\/10.36660\/abc.20240621","relation":{"is-translation-of":[{"id-type":"doi","id":"10.36660\/abc.20240621i","asserted-by":"subject"},{"id-type":"doi","id":"10.36660\/abc.20240621i","asserted-by":"object"}]},"ISSN":["1678-4170","0066-782X"],"issn-type":[{"value":"1678-4170","type":"electronic"},{"value":"0066-782X","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20240621"}}