{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:21Z","timestamp":1772253141648,"version":"3.50.1"},"reference-count":35,"publisher":"Sociedade Brasileira de Cardiologia","issue":"4","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  A cardiomiopatia hipertr\u00f3fica (CMH) apresenta altera\u00e7\u00f5es ecocardiogr\u00e1ficas importantes para diagn\u00f3stico e progn\u00f3stico. Os dados da literatura nacional s\u00e3o escassos.  Objetivo  Avaliar, em uma coorte brasileira de pacientes com CMH, as caracter\u00edsticas cl\u00ednicas, ecocardiogr\u00e1ficas e a evolu\u00e7\u00e3o da doen\u00e7a.  M\u00e9todos  Coorte retrospectiva de pacientes com CMH e idade \u2265 18 anos. Foram exclu\u00eddos pacientes com estenose a\u00f3rtica moderada ou importante e aqueles submetidos \u00e0 redu\u00e7\u00e3o septal. O n\u00edvel de signific\u00e2ncia adotado na an\u00e1lise estat\u00edstica foi de 5%.  Resultados  Foram inclu\u00eddos 1244 pacientes, entre os anos de 2010 e 2022, com tempo m\u00e9dio de seguimento de 7,7 anos \u00b1 4,5, sendo 53,6% homens. A idade m\u00e9dia foi de 54,6 anos \u00b1 16,5, e a fra\u00e7\u00e3o de eje\u00e7\u00e3o do ventr\u00edculo esquerdo (FEVE) m\u00e9dia foi de 65,8% \u00b1 7,6. A FEVE \u2264 50% foi observada em 5,8% dos pacientes, a forma assim\u00e9trica em 88,7% e a hipertrofia septal em 85,4%. Movimento sist\u00f3lico anterior da valva mitral foi encontrado em 30,1% dos pacientes, obstru\u00e7\u00e3o da via de sa\u00edda do ventr\u00edculo esquerdo em 30,7% e septo \u2265 28 mm em 7,2%. Apenas 1 paciente apresentou aneurisma ventricular. Fibrila\u00e7\u00e3o\/flutter atrial ocorreu em 9,6% dos pacientes. A mortalidade geral ocorreu em 232 pacientes (1,3%\/ano). Pacientes com pept\u00eddeo natriur\u00e9tico tipo B (BNP) &gt; 200 pg\/ml, \u00e1trio esquerdo \u2265 45 mm e FEVE \u2264 50% apresentaram maior mortalidade (p &lt; 0,001). Al\u00e9m disso, idade e fibrila\u00e7\u00e3o\/flutter atrial tamb\u00e9m foram relacionadas com mortalidade.  Conclus\u00f5es  A maioria dos pacientes apresentava FEVE &gt; 50%, hipertrofia assim\u00e9trica e predom\u00ednio septal. BNP, di\u00e2metro do AE, FEVE \u2264 50%, idade e fibrila\u00e7\u00e3o\/flutter atrial foram associados com pior progn\u00f3stico.<\/jats:p>","DOI":"10.36660\/abc.20240640","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T09:40:58Z","timestamp":1747042858000},"source":"Crossref","is-referenced-by-count":0,"title":["Particularidades Cl\u00ednicas e Ecocardiogr\u00e1ficas da Cardiomiopatia Hipertr\u00f3fica em uma Popula\u00e7\u00e3o Brasileira e seu Impacto Progn\u00f3stico"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6000-1297","authenticated-orcid":false,"given":"Georgina Del Cisne Jad\u00e1n","family":"Luzuriaga","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmundo","family":"Arteaga-Fernandez","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9236-3815","authenticated-orcid":false,"given":"Viviane Tiemi","family":"Hotta","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Ianni","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Nastari","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2437-2485","authenticated-orcid":false,"given":"Felix","family":"Ramires","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6477-8741","authenticated-orcid":false,"given":"Guilherme Wesley Peixoto da","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-199X","authenticated-orcid":false,"given":"Charles","family":"Mady","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-8805","authenticated-orcid":false,"given":"F\u00e1bio","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-3841","authenticated-orcid":false,"given":"Juliano Novaes","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil; Faculdade Santa Marcelina,  Brasil; Hospital Santa Marcelina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"23","key":"ref1","doi-asserted-by":"crossref","first-page":"e1239","DOI":"10.1161\/CIR.0000000000001250","article-title":"2024 AHA\/ACC\/AMSSM\/HRS\/PACES\/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Ommen SR","year":"2024","journal-title":"Circulation"},{"issue":"37","key":"ref2","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC Guidelines for the Management of Cardiomyopathies","volume":"44","author":"Arbelo E","year":"2023","journal-title":"Eur Heart J"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-10389-4","article-title":"Comparison of Mortality and Cause of Death between Adults with and without Hypertrophic Cardiomyopathy","volume":"12","author":"Kwon S","year":"2022","journal-title":"Sci Rep"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/jamacardio.2019.4534","article-title":"Mortality Among Referral Patients with Hypertrophic Cardiomyopathy vs the General European Population","volume":"5","author":"Lorenzini M","year":"2020","journal-title":"JAMA Cardiol"},{"key":"ref5","article-title":"Long Term Mortality in Patients with Hypertrophic Cardiomyopathy - A Danish Nationwide Study","volume":"25","author":"Jacobsen MB","year":"2022","journal-title":"Am Heart J Plus"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1080\/13696998.2023.2277076","article-title":"Cardiovascular Outcomes by Time-Varying New York Heart Association Class Among Patients with Obstructive Hypertrophic Cardiomyopathy: A Retrospective Cohort Study","volume":"26","author":"Wang Y","year":"2023","journal-title":"J Med Econ"},{"issue":"5","key":"ref7","article-title":"Clinical Outcomes in Patients with Nonobstructive, Labile, and Obstructive Hypertrophic Cardiomyopathy","volume":"7","author":"Lu DY","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","DOI":"10.36660\/abc.20240415i","article-title":"Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy - 2024","volume":"121","author":"Fernandes F","year":"2024","journal-title":"Arq Bras Cardiol"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jchf.2017.09.011","article-title":"Clinical Spectrum and Management of Heart Failure in Hypertrophic Cardiomyopathy","volume":"6","author":"Maron BJ","year":"2018","journal-title":"JACC Heart Fail"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jcmg.2020.09.037","article-title":"Progression of Myocardial Fibrosis in Hypertrophic Cardiomyopathy: A Cardiac Magnetic Resonance Study","volume":"14","author":"Habib M","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"issue":"17","key":"ref11","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1093\/eurheartj\/ehq136","article-title":"Clinicopathological Profiles of Progressive Heart Failure in Hypertrophic Cardiomyopathy","volume":"31","author":"Melacini P","year":"2010","journal-title":"Eur Heart J"},{"issue":"19","key":"ref12","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.jacc.2019.08.1057","article-title":"Distinct Subgroups in Hypertrophic Cardiomyopathy in the NHLBI HCM Registry","volume":"74","author":"Neubauer S","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"23","key":"ref13","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.027618","article-title":"Circulating Biomarkers in Hypertrophic Cardiomyopathy","volume":"11","author":"Matthia EL","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.hrthm.2018.04.030","article-title":"B-Type Natriuretic Peptide and Risk of Sudden Death in Patients with Hypertrophic Cardiomyopathy","volume":"15","author":"Minami Y","year":"2018","journal-title":"Heart Rhythm"},{"issue":"24","key":"ref15","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1016\/j.jacc.2013.04.004","article-title":"B-Type Natriuretic Peptide and Survival in Hypertrophic Cardiomyopathy","volume":"61","author":"Geske JB","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"22","key":"ref16","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1161\/CIRCULATIONAHA.123.065037","article-title":"Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy","volume":"148","author":"Rowin EJ","year":"2023","journal-title":"Circulation"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13020501","article-title":"Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy and Cardiac Amyloidosis: From Clinical Management to Catheter Ablation Indication","volume":"13","author":"Mistrulli R","year":"2024","journal-title":"J Clin Med"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/heartjnl-2013-304276","article-title":"Atrial Fibrillation and Thromboembolism in Patients with Hypertrophic Cardiomyopathy: Systematic Review","volume":"100","author":"Guttmann OP","year":"2014","journal-title":"Heart"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10741-018-9752-6","article-title":"Atrial Fibrillation in Hypertrophic Cardiomyopathy: Prevalence, Clinical Impact, and Management","volume":"24","author":"Garg L","year":"2019","journal-title":"Heart Fail Rev"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/clc.23050","article-title":"Clinical and Echocardiographic Parameters as Risk Factors for Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy","volume":"41","author":"Klopotowski M","year":"2018","journal-title":"Clin Cardiol"},{"issue":"21","key":"ref21","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1161\/hc4601.097997","article-title":"Impact of Atrial Fibrillation on the Clinical Course of Hypertrophic Cardiomyopathy","volume":"104","author":"Olivotto I","year":"2001","journal-title":"Circulation"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1002\/ehf2.13563","article-title":"Clinical Significance of New-Onset Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy","volume":"8","author":"Kubo T","year":"2021","journal-title":"ESC Heart Fail"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001002","article-title":"Atrial Fibrillation in Hypertrophic Cardiomyopathy: Prevalence, Clinical Correlations, and Mortality in a Large High-Risk Population","volume":"3","author":"Siontis KC","year":"2014","journal-title":"J Am Heart Assoc"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","DOI":"10.3390\/genes14112042","article-title":"Hypertrophic Cardiomyopathy in Underrepresented Populations: Clinical and Genetic Landscape Based on a Russian Single-Center Cohort Study","volume":"14","author":"Chumakova OS","year":"2023","journal-title":"Genes"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11897-021-00526-x","article-title":"Sex Differences in Hypertrophic Cardiomyopathy: Interaction with Genetics and Environment","volume":"18","author":"Butters A","year":"2021","journal-title":"Curr Heart Fail Rep"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.026270","article-title":"Is There a Sex Difference in the Prognosis of Hypertrophic Cardiomyopathy? A Systematic Review and Meta-Analysis","volume":"12","author":"Zhao H","year":"2023","journal-title":"J Am Heart Assoc"},{"issue":"21","key":"ref27","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012041","article-title":"Impact of Sex on Clinical Course and Survival in the Contemporary Treatment Era for Hypertrophic Cardiomyopathy","volume":"8","author":"Rowin EJ","year":"2019","journal-title":"J Am Heart Assoc"},{"issue":"46","key":"ref28","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1093\/eurheartj\/ehx527","article-title":"Women with Hypertrophic Cardiomyopathy Have Worse Survival","volume":"38","author":"Geske JB","year":"2017","journal-title":"Eur Heart J"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/heartjnl-2020-316693","article-title":"Differing Strategies for Sudden Death Prevention in Hypertrophic Cardiomyopathy","volume":"109","author":"Maron MS","year":"2023","journal-title":"Heart"},{"issue":"3","key":"ref30","first-page":"210","article-title":"Prognostic Value of the Collagen Volume Fraction in Hypertrophic Cardiomyopathy","volume":"92","author":"Arteaga E","year":"2009","journal-title":"Arq Bras Cardiol"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.jcmg.2022.03.029","article-title":"Clinical Characteristics and Prognostic Importance of Left Ventricular Apical Aneurysms in Hypertrophic Cardiomyopathy","volume":"15","author":"Lee DZJ","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jacc.2021.11.021","article-title":"Management of Hypertrophic Cardiomyopathy: JACC State-of-the-Art Review","volume":"79","author":"Maron BJ","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"19","key":"ref33","article-title":"Clinical Characteristics and Outcomes in Patients with Apical and Nonapical Hypertrophic Cardiomyopathy","volume":"13","author":"Chen QF","year":"2024","journal-title":"J Am Heart Assoc"},{"issue":"20","key":"ref34","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.036245","article-title":"Distinct Phenotypic Groups and Related Clinical Outcomes in Patients with Hypertrophic Cardiomyopathy","volume":"13","author":"Kwak S","year":"2024","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"ref35","first-page":"1247","article-title":"Prognosis for Patients with Apical Hypertrophic Cardiomyopathy: A Multicenter Cohort Study Based on Propensity Score Matching","volume":"81","author":"Ma H","year":"2023","journal-title":"Kardiol Pol"}],"container-title":["Arquivos Brasileiros de Cardiologia"],"original-title":["Clinical and Echocardiographic Particularities of Hypertrophic Cardiomyopathy in a Brazilian Population and its Prognostic Impact"],"link":[{"URL":"https:\/\/abccardiol.org\/wp-content\/uploads\/articles_xml\/0066-782x-abc-122-4-e20240640\/0066-782x-abc-122-4-e20240640.x95083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T09:41:04Z","timestamp":1747042864000},"score":1,"resource":{"primary":{"URL":"https:\/\/abccardiol.org\/article\/particularidades-clinicas-e-ecocardiograficas-da-cardiomiopatia-hipertrofica-em-uma-populacao-brasileira-e-seu-impacto-prognostico\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0066-782X2025000400306"],"URL":"https:\/\/doi.org\/10.36660\/abc.20240640","relation":{"is-translation-of":[{"id-type":"doi","id":"10.36660\/abc.20240640i","asserted-by":"subject"},{"id-type":"doi","id":"10.36660\/abc.20240640i","asserted-by":"object"}]},"ISSN":["1678-4170","0066-782X"],"issn-type":[{"value":"1678-4170","type":"electronic"},{"value":"0066-782X","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20240640"}}