{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T10:40:29Z","timestamp":1772361629507,"version":"3.50.1"},"reference-count":38,"publisher":"Sociedade Brasileira de Cardiologia","issue":"8","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo O gerenciamento direcionado de temperatura (GDT) \u00e9 atualmente a \u00fanica interven\u00e7\u00e3o potencialmente neuroprotetora recomendada para cuidados p\u00f3s-parada card\u00edaca. No entanto, h\u00e1 preocupa\u00e7\u00f5es entre a comunidade cient\u00edfica em rela\u00e7\u00e3o \u00e0s evid\u00eancias conflitantes que apoiam essa recomenda\u00e7\u00e3o. Al\u00e9m disso, a maior parte dos ensaios inclu\u00eddos em revis\u00f5es sistem\u00e1ticas que informam diretrizes e recomenda\u00e7\u00f5es foram conduzidos em pa\u00edses desenvolvidos, com mix de casos e caracter\u00edsticas dos pacientes que diferem significativamente da realidade de pa\u00edses em desenvolvimento como o Brasil. Temperaturas corporais elevadas induzem altera\u00e7\u00f5es na integridade da barreira hematoencef\u00e1lica e aumentam a demanda cerebral por oxig\u00eanio. Podem causar desequil\u00edbrios no metabolismo de oxig\u00eanio cerebral e no fluxo sangu\u00edneo, levando \u00e0 inflama\u00e7\u00e3o e apoptose. O objetivo principal do GDT \u00e9 controlar as vias secund\u00e1rias de les\u00e3o, evitando altas temperaturas. O GDT, anteriormente denominado hipotermia terap\u00eautica, foi usado pela primeira vez para tratar les\u00e3o cerebral p\u00f3s-parada card\u00edaca na d\u00e9cada de 1950. Desde ent\u00e3o, temos realizado ensaios cl\u00ednicos relevantes sobre o GDT, com resultados conflitantes, como os seguintes: GDT1, estudo HACA, GDT2, estudo HYPERION e algumas metan\u00e1lises mantiveram o manejo da temperatura ap\u00f3s uma parada card\u00edaca em discuss\u00e3o. Al\u00e9m de individualizar a temperatura-alvo ideal para cen\u00e1rios cl\u00ednicos e perfis de pacientes espec\u00edficos, outros aspectos da administra\u00e7\u00e3o de GDT de alta qualidade s\u00e3o cruciais. O momento de obten\u00e7\u00e3o da temperatura-alvo, a dura\u00e7\u00e3o do resfriamento, as taxas de reaquecimento e as pr\u00e1ticas de seda\u00e7\u00e3o foram avaliados em ensaios cl\u00ednicos recentes. Em conclus\u00e3o, \u00e9 crucial determinar a abordagem de GDT mais eficaz para alcan\u00e7ar os melhores resultados neurol\u00f3gicos poss\u00edveis, minimizando os potenciais efeitos adversos.<\/jats:p>","DOI":"10.36660\/abc.20240696","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T17:06:02Z","timestamp":1760461562000},"source":"Crossref","is-referenced-by-count":1,"title":["Controle de Temperatura ap\u00f3s Parada Card\u00edaca: Uma Revis\u00e3o Narrativa na Perspectiva de um Pa\u00eds em Desenvolvimento"],"prefix":"10.36660","volume":"122","author":[{"given":"Rafaela dos Santos","family":"Braga","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3247-3123","authenticated-orcid":false,"given":"Gisele Sampaio","family":"Silva","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein,  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