{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:59Z","timestamp":1772253239408,"version":"3.50.1"},"reference-count":54,"publisher":"Sociedade Brasileira de Cardiologia","issue":"11","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  O papel do RNA longo n\u00e3o codificante ZEB1-AS1 na hipertrofia card\u00edaca (HC) permanece incerto.  Objetivos  Investigar a fun\u00e7\u00e3o do ZEB1-AS1 no desenvolvimento e na progress\u00e3o da HC, bem como elucidar seu mecanismo molecular subjacente.  M\u00e9todos  Os n\u00edveis de express\u00e3o de RNA foram quantificados por PCR quantitativa em tempo real. A \u00e1rea de superf\u00edcie das c\u00e9lulas AC16 foi avaliada por colora\u00e7\u00e3o por imunofluoresc\u00eancia. A express\u00e3o proteica foi analisada por Western blotting. As intera\u00e7\u00f5es entre RNAs foram examinadas por ensaios com rep\u00f3rter de luciferase e por imunoprecipita\u00e7\u00e3o de RNA. A signific\u00e2ncia estat\u00edstica foi definida como p &lt; 0,05.  Resultados  A express\u00e3o de ZEB1-AS1 esteve aumentada em tecidos mioc\u00e1rdicos e em c\u00e9lulas AC16 estimuladas com isoproterenol (ISO). O knockdown de ZEB1-AS1 atenuou as respostas hipertr\u00f3ficas induzidas por ISO. Mecanisticamente, ZEB1-AS1 modulou a express\u00e3o de desacetilase de histonas 2 (HDAC2) atuando como \u201cesponja molecular\u201d para miR-186-5p. De forma consistente, o knockdown de ZEB1-AS1 reduziu a HDAC2 e diminuiu a express\u00e3o de marcadores hipertr\u00f3ficos, incluindo o pept\u00eddeo natriur\u00e9tico tipo B, o pept\u00eddeo natriur\u00e9tico atrial e a cadeia pesada de miosina \u03b2, restringindo assim a progress\u00e3o da HC.  Conclus\u00f5es  ZEB1-AS1 encontra-se superexpresso em tecidos mioc\u00e1rdicos e em c\u00e9lulas AC16 estimuladas com ISO. Nossos achados indicam que o eixo ZEB1-AS1\/miR-186-5p\/HDAC2 contribui para a HC, oferecendo uma base mecan\u00edstica e um potencial alvo terap\u00eautico para interven\u00e7\u00e3o cl\u00ednica.<\/jats:p>","DOI":"10.36660\/abc.20240703","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T14:47:26Z","timestamp":1768920446000},"source":"Crossref","is-referenced-by-count":0,"title":["Knockdown do RNA Longo N\u00e3o Codificante ZEB1-AS1 Acelera a Hipertrofia Card\u00edaca pela Via miR-186-5p\/HDAC2"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8118-8347","authenticated-orcid":false,"given":"Bingfeng","family":"Cao","sequence":"first","affiliation":[{"name":"Weihai Central Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6074-1619","authenticated-orcid":false,"given":"Qingxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Weihai Central Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3623-6982","authenticated-orcid":false,"given":"Xiaoyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Weihai Central Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9989-7969","authenticated-orcid":false,"given":"Yufeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Weihai Central Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41569-022-00806-6","article-title":"Regression of Cardiac Hypertrophy in Health and Disease: Mechanisms and Therapeutic Potential","volume":"20","author":"Martin TG","year":"2023","journal-title":"Nat Rev 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