{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:57Z","timestamp":1772253237640,"version":"3.50.1"},"reference-count":44,"publisher":"Sociedade Brasileira de Cardiologia","issue":"8","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento A doen\u00e7a hep\u00e1tica esteat\u00f3tica associada \u00e0 disfun\u00e7\u00e3o metab\u00f3lica (DHEADM) \u00e9 a enfermidade hep\u00e1tica mais prevalente no mundo. A DHEADM pode progredir para fibrose e complica\u00e7\u00f5es associadas, sendo a doen\u00e7a cardiovascular a principal causa de morte nesses indiv\u00edduos. Marcadores de aterosclerose carot\u00eddea s\u00e3o capazes de predizer desfechos cardiovasculares, o que ressalta a import\u00e2ncia de sua associa\u00e7\u00e3o com a fibrose hep\u00e1tica.  Objetivo Avaliar a rela\u00e7\u00e3o entre fibrose hep\u00e1tica na DHEADM e aterosclerose subcl\u00ednica, por meio da an\u00e1lise da espessura m\u00e9dio-intimal da car\u00f3tida (EMIC), da idade vascular (IV) e da presen\u00e7a de placas ateroscler\u00f3ticas.  M\u00e9todos Estudo prospectivo conduzido com participantes sob risco para DHEADM. A esteatose e a fibrose hep\u00e1ticas foram avaliadas por ultrassonografia e elastografia hep\u00e1tica, com uso do par\u00e2metro de atenua\u00e7\u00e3o controlada. A aterosclerose carot\u00eddea foi analisada por meio de ultrassonografia de car\u00f3tidas, medi\u00e7\u00f5es da EMIC e da IV. Adotou-se n\u00edvel de signific\u00e2ncia de 5% (p &lt; 0,05).  Resultados Foram inclu\u00eddos 114 participantes, com idade mediana de 64 anos (IIQ: 55\u201368), sendo 96 (84%) do sexo feminino. A esteatose foi identificada em 99 participantes (86,8%) e a fibrose em 31 (27,2%). Placas ateroscler\u00f3ticas estavam presentes em 33 indiv\u00edduos (28,9%), sem diferen\u00e7a significativa na frequ\u00eancia entre os grupos. No entanto, o grupo com fibrose apresentou EMIC mais elevada e IV aumentada. Em uma an\u00e1lise de subgrupo com 85 participantes com diabetes mellitus tipo 2 (DM2), 27 (31,8%) apresentavam fibrose. Esses indiv\u00edduos apresentaram EMIC superior (0,742 mm vs. 0,653 mm; p &lt; 0,05) e IV nove anos acima da idade cronol\u00f3gica, quando comparados aos indiv\u00edduos sem fibrose (p &lt; 0,05).  Conclus\u00e3o Este estudo demonstra que indiv\u00edduos com DHEADM e fibrose hep\u00e1tica apresentam maior envelhecimento vascular e risco cardiovascular aumentado, refletidos por eleva\u00e7\u00f5es na EMIC e na IV.<\/jats:p>","DOI":"10.36660\/abc.20240856","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T16:12:45Z","timestamp":1760458365000},"source":"Crossref","is-referenced-by-count":0,"title":["Rela\u00e7\u00e3o entre Fibrose Hep\u00e1tica Decorrente da Doen\u00e7a Hep\u00e1tica Gordurosa Associada \u00e0 Disfun\u00e7\u00e3o Metab\u00f3lica e Aterosclerose Subcl\u00ednica"],"prefix":"10.36660","volume":"122","author":[{"given":"Daniele Araujo de Azeredo","family":"Coutinho","sequence":"first","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-670X","authenticated-orcid":false,"given":"Jenaine Rosa","family":"Godinho","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael Carreiro","family":"Moura","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio Martins","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hevila Faria","family":"Passos","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordana de Paula Felipe","family":"Mendes","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Roberto Moraes de","family":"Andrade Junior","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Guillermo","family":"Coca-Velarde","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Auxiliadora Nogueira","family":"Saad","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5358-5426","authenticated-orcid":false,"given":"Priscila Pollo","family":"Flores","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7905-0988","authenticated-orcid":false,"given":"Debora Vieira","family":"Soares","sequence":"additional","affiliation":[{"name":"Universidade 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