{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T20:13:38Z","timestamp":1773346418295,"version":"3.50.1"},"reference-count":29,"publisher":"Sociedade Brasileira de Cardiologia","issue":"7","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  A osteoartrite \u00e9 um tipo prevalente de artrite caracterizada por altera\u00e7\u00f5es degenerativas cr\u00f4nicas no sistema m\u00fasculo-esquel\u00e9tico, que podem resultar em danos articulares e dor cr\u00f4nica.  Objetivo  Este estudo investigou as associa\u00e7\u00f5es entre o \u00edndice de ativa\u00e7\u00e3o e estresse endotelial (EASIX) e o aumento do risco de doen\u00e7a cardiovascular ateroscler\u00f3tica (DCVA) e mortalidade por todas as causas entre pacientes diagnosticados com osteoartrite.  M\u00e9todos  O estudo de coorte abrangeu 2.028 indiv\u00edduos com idades entre 40 e 79 anos com osteoartrite, utilizando dados do banco de dados do National Health and Nutrition Examination Surveys (NHANES) abrangendo os anos de 2007 a 2018. O modelo de regress\u00e3o log\u00edstica ponderada univariada e o modelo de Cox ponderado foram estabelecidos, respectivamente, para rastrear poss\u00edveis fatores de confus\u00e3o. Um n\u00edvel de signific\u00e2ncia de p &lt; 0,05 foi adotado para todas as an\u00e1lises estat\u00edsticas.  Resultados  O estudo revelou um risco elevado de DCVA em correla\u00e7\u00e3o com um log (EASIX) aumentado (raz\u00e3o de chances: 1,94, com intervalo de confian\u00e7a de 95%: 1,57-2,41). Quando comparados a indiv\u00edduos com log (EASIX) &lt; -1,29, aqueles com log (EASIX)&gt;-0,78 demonstraram um risco aumentado de DCVA (raz\u00e3o de chances: 2,31, com intervalo de confian\u00e7a de 95%: 1,68-3,18). Um valor de log (EASIX) mais alto tamb\u00e9m foi associado a um risco aumentado de mortalidade por todas as causas (raz\u00e3o de risco: 1,59, com intervalo de confian\u00e7a de 95%: 1,14-2,23). Entre os indiv\u00edduos diagnosticados com osteoartrite, aqueles que apresentaram log (EASIX)&gt;-0,78 apresentaram maior risco de morrer por qualquer causa, em compara\u00e7\u00e3o aos pacientes com log (EASIX) &lt;-1,29.  Conclus\u00e3o  A presen\u00e7a de um alto \u00edndice EASIX foi associada a um risco aumentado de DCVA e mortalidade por todas as causas entre pacientes com osteoartrite.<\/jats:p>","DOI":"10.36660\/abc.20250012","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T19:30:32Z","timestamp":1754076632000},"source":"Crossref","is-referenced-by-count":1,"title":["Associa\u00e7\u00e3o da Ativa\u00e7\u00e3o Endotelial e do \u00cdndice de Estresse com Risco de Doen\u00e7a Cardiovascular e Mortalidade por Todas as Causas em Pacientes com Osteoartrite"],"prefix":"10.36660","volume":"122","author":[{"given":"Ruoyan","family":"Li","sequence":"first","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoqun","family":"Feng","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kexin","family":"Lin","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7218-0046","authenticated-orcid":false,"given":"Xiaohong","family":"Fan","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","first-page":"3","article-title":"Osteoarthritis is a Serious Disease","volume":"37","author":"Hawker GA","year":"2019","journal-title":"Clin Exp 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