{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:11:21Z","timestamp":1778695881517,"version":"3.51.4"},"reference-count":38,"publisher":"Sociedade Brasileira de Cardiologia","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  A patog\u00eanese da doen\u00e7a card\u00edaca valvar (DCV) permanece incerta, o que destaca a necessidade de mais pesquisas sobre os fatores de risco.  Objetivos  Explorar as poss\u00edveis rela\u00e7\u00f5es causais entre as caracter\u00edsticas das c\u00e9lulas sangu\u00edneas e quatro tipos de doen\u00e7as valvares card\u00edacas: doen\u00e7a card\u00edaca reum\u00e1tica, doen\u00e7a da v\u00e1lvula mitral, doen\u00e7a da v\u00e1lvula a\u00f3rtica e doen\u00e7a da v\u00e1lvula tric\u00faspide.  M\u00e9todos  Este estudo utilizou estat\u00edsticas resumidas de GWAS em larga escala e uma abordagem de randomiza\u00e7\u00e3o mendeliana de duas amostras, analisando treze caracter\u00edsticas de c\u00e9lulas sangu\u00edneas como exposi\u00e7\u00f5es e quatro fen\u00f3tipos de DCV como desfechos. O principal m\u00e9todo de randomiza\u00e7\u00e3o mendeliana foi a vari\u00e2ncia inversa ponderada (IVW), complementada pelos m\u00e9todos MR-Egger, mediana ponderada e moda ponderada, com extensas an\u00e1lises de sensibilidade para verificar a confiabilidade dos resultados, onde um valor de p &lt; 0,05 foi considerado estatisticamente significativo.  Resultados  Dentre as treze caracter\u00edsticas das c\u00e9lulas sangu\u00edneas examinadas, a contagem de neutr\u00f3filos apresentou associa\u00e7\u00e3o causal positiva com doen\u00e7a da valva mitral (OR = 1,46, IC 95%: 1,16-1,85, p &lt; 0,001) utilizando o m\u00e9todo IVW. Esse achado foi corroborado pelo m\u00e9todo MR-Egger (OR = 1,73, IC 95%: 1,09-2,75, p = 0,02), refor\u00e7ando a evid\u00eancia dessa rela\u00e7\u00e3o causal. Para essa an\u00e1lise, 253 variantes gen\u00e9ticas robustas foram utilizadas como vari\u00e1veis instrumentais. Adicionalmente, o volume corpuscular m\u00e9dio (VCM) apresentou associa\u00e7\u00e3o causal negativa com doen\u00e7a da valva tric\u00faspide (OR = 0,65, IC 95%: 0,44-0,96, p = 0,03) utilizando o m\u00e9todo IVW, com base em 268 vari\u00e1veis instrumentais. Outras caracter\u00edsticas das c\u00e9lulas sangu\u00edneas n\u00e3o apresentaram rela\u00e7\u00f5es causais significativas com a DCV. Uma an\u00e1lise de sensibilidade abrangente corroborou a robustez dos nossos resultados.  Conclus\u00f5es  Os resultados deste estudo sugerem um poss\u00edvel envolvimento causal da contagem de neutr\u00f3filos e do VCM no desenvolvimento de doen\u00e7as da v\u00e1lvula mitral e da v\u00e1lvula tric\u00faspide, respectivamente.<\/jats:p>","DOI":"10.36660\/abc.20250063","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:09:04Z","timestamp":1778692144000},"source":"Crossref","is-referenced-by-count":0,"title":["Rela\u00e7\u00e3o Causal entre Caracter\u00edsticas das C\u00e9lulas Sangu\u00edneas e Doen\u00e7a Card\u00edaca Valvar: Um Estudo de Randomiza\u00e7\u00e3o Mendeliana com Duas Amostras"],"prefix":"10.36660","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6632-8768","authenticated-orcid":false,"given":"Xiaoli","family":"Wu","sequence":"first","affiliation":[{"name":"Panzhihua Central Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Panzhihua Central Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4848-0919","authenticated-orcid":false,"given":"Jinyu","family":"Tian","sequence":"additional","affiliation":[{"name":"Panzhihua Central Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s41569-021-00570-z","article-title":"Global Epidemiology of Valvular Heart Disease","volume":"18","author":"Coffey S","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pcad.2023.06.002","article-title":"The Common Pathobiology between Coronary Artery Disease and Calcific 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