{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:08Z","timestamp":1772253188725,"version":"3.50.1"},"reference-count":36,"publisher":"Sociedade Brasileira de Cardiologia","issue":"7","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  As doen\u00e7as cardiovasculares constituem a principal causa de mortalidade no mundo, gerando impactos sociais e econ\u00f4micos significativos. Essas condi\u00e7\u00f5es frequentemente coexistem com comorbidades, como a disfun\u00e7\u00e3o renal.  Objetivos  Avaliar a associa\u00e7\u00e3o entre a depura\u00e7\u00e3o de creatinina e a incid\u00eancia de desfechos cardiovasculares no per\u00edodo de 1 ano em pacientes com diagn\u00f3stico de infarto agudo do mioc\u00e1rdio (IAM).  M\u00e9todos  Este estudo de coorte prospectivo incluiu pacientes hospitalizados em decorr\u00eancia do primeiro epis\u00f3dio de IAM. A depura\u00e7\u00e3o de creatinina foi analisada em rela\u00e7\u00e3o aos desfechos cardiovasculares, incluindo recidiva de IAM, acidente vascular cerebral e \u00f3bito de causa cardiovascular. Valores de p &lt;0,05 foram considerados estatisticamente significativos.  Resultados  Foram analisados 1.324 pacientes, com idade m\u00e9dia de 60,9 \u00b1 11,4 anos, dos quais 67,4% do sexo masculino. Depura\u00e7\u00e3o de creatinina inferior a 60 ml\/min apresentou associa\u00e7\u00e3o significativa com hipertens\u00e3o arterial sist\u00eamica (79,6% vs. 55,1%; p&lt;0,001), diabetes mellitus (40,8% vs. 24,5%; p&lt;0,001) e dislipidemia (38,8% vs. 31,4%; p=0,043). Valores mais elevados de depura\u00e7\u00e3o de creatinina associaram-se a menor risco de eventos adversos cardiovasculares maiores (MACEs) em 1 ano (HR: 0,992; IC 95%: 0,984-0,999; p=0,030). Ademais, verificou-se associa\u00e7\u00e3o com menor mortalidade geral (HR: 0,984; IC 95%: 0,970-0,998; p=0,021).  Conclus\u00e3o  Valores mais elevados de depura\u00e7\u00e3o de creatinina associaram-se a menores raz\u00f5es de risco para MACEs e mortalidade geral no per\u00edodo de 1 ano ap\u00f3s o IAM.<\/jats:p>","DOI":"10.36660\/abc.20250082","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T16:30:31Z","timestamp":1755534631000},"source":"Crossref","is-referenced-by-count":0,"title":["Associa\u00e7\u00e3o entre a Fun\u00e7\u00e3o Renal e a Incid\u00eancia de Desfechos Cardiovasculares Maiores em 1 Ano Ap\u00f3s o Primeiro Infarto Agudo do Mioc\u00e1rdio"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-8003","authenticated-orcid":false,"given":"Daniel Medeiros","family":"Moreira","sequence":"first","affiliation":[{"name":"Universidade do Sul de Santa Catarina,  Brasil; Instituto de Cardiologia de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Ant\u00f4nio de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Universidade do Sul de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda Scarduelli","family":"Cechinel","sequence":"additional","affiliation":[{"name":"Universidade do Sul de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto L\u00e9o da","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammuz","family":"Fattah","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo de Moura","family":"Joaquim","sequence":"additional","affiliation":[{"name":"Universidade do Sul de Santa Catarina,  Brasil; Instituto de Cardiologia de Santa Catarina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"s03","DOI":"10.1590\/1806-9282.66.s1.3","article-title":"Chronic Kidney Disease","volume":"66","author":"Ammirati AL","year":"2020","journal-title":"Rev Assoc Med Bras"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/CIRCULATIONAHA.120.050686","article-title":"Cardiovascular Disease in Chronic Kidney Disease: Pathophysiological Insights and Therapeutic Options","volume":"143","author":"Jankowski J","year":"2021","journal-title":"Circulation"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of Chronic Kidney Disease: An Update 2022","volume":"12","author":"Kovesdy CP","year":"2022","journal-title":"Kidney Int 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