{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:35:12Z","timestamp":1777988112802,"version":"3.51.4"},"reference-count":44,"publisher":"Sociedade Brasileira de Cardiologia","issue":"12","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo Por meio da compara\u00e7\u00e3o das respostas de volunt\u00e1rios normais, a avalia\u00e7\u00e3o da fun\u00e7\u00e3o auton\u00f4mica em condi\u00e7\u00f5es cl\u00ednicas anormais se focou na detec\u00e7\u00e3o de disautonomia envolvendo os sistemas parassimp\u00e1tico e adren\u00e9rgico em pacientes com cardiopatia chag\u00e1sica, p\u00f3s-cirurgia card\u00edaca, insufici\u00eancia card\u00edaca cr\u00f4nica, prolapso da valva mitral e hipertireoidismo. Em particular, o comprometimento auton\u00f4mico observado em pacientes com doen\u00e7a de Chagas envolveu predominantemente o controle parassimp\u00e1tico da frequ\u00eancia card\u00edaca ao n\u00edvel do n\u00f3 sinusal e a inerva\u00e7\u00e3o adren\u00e9rgica ao n\u00edvel ventricular do mioc\u00e1rdio. Os dist\u00farbios auton\u00f4micos observados em pacientes com cardiomiopatia chag\u00e1sica s\u00f3 recentemente foram explorados em termos de sua relev\u00e2ncia progn\u00f3stica, e suas potenciais implica\u00e7\u00f5es cl\u00ednicas para fins terap\u00eauticos ainda precisam ser investigadas. Ao longo das \u00faltimas quase sete d\u00e9cadas, nosso laborat\u00f3rio acumulou expertise significativa utilizando diversos testes descritos acima para avaliar o controle auton\u00f4mico da frequ\u00eancia card\u00edaca, agora com foco em diversas condi\u00e7\u00f5es cl\u00ednicas fisiopatol\u00f3gicas. O efeito do treinamento f\u00edsico de resist\u00eancia e do envelhecimento foi focado principalmente em estudos com volunt\u00e1rios normais, cujas respostas basais serviram como controles a serem comparados durante testes empregados em indiv\u00edduos com algumas condi\u00e7\u00f5es cl\u00ednicas m\u00f3rbidas. De longe, a fisiopatologia da cardiopatia chag\u00e1sica envolvendo o sistema nervoso aut\u00f4nomo foi o assunto mais predominantemente estudado em nosso laborat\u00f3rio, desde os primeiros estudos na d\u00e9cada de 1960 at\u00e9 os estudos tardios recentemente publicados em peri\u00f3dicos internacionais (Figura Central). Outras condi\u00e7\u00f5es patol\u00f3gicas focadas em nossos estudos foram prolapso da valva mitral, insufici\u00eancia card\u00edaca, p\u00f3s-cirurgia card\u00edaca e hipertireoidismo.<\/jats:p>","DOI":"10.36660\/abc.20250112","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T18:47:01Z","timestamp":1770317221000},"source":"Crossref","is-referenced-by-count":0,"title":["II \u2013 Avalia\u00e7\u00e3o do Controle Auton\u00f4mico da Frequ\u00eancia Card\u00edaca em Diversas Condi\u00e7\u00f5es Cl\u00ednicas"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3456-8433","authenticated-orcid":false,"given":"Benedito Carlos","family":"Maciel","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louren\u00e7o","family":"Gallo-Jr","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1090-8165","authenticated-orcid":false,"given":"Andr\u00e9","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Marin-Neto","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.106.624296","article-title":"Pathogenesis of Chronic Chagas Heart Disease","volume":"115","author":"Marin-Neto JA","year":"2007","journal-title":"Circulation"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/01.CIR.38.2.289","article-title":"Effects of Acute Elevation in Blood Pressure and of Atropine on Heart Rate in Chagas' Disease. 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