{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:06Z","timestamp":1772253186843,"version":"3.50.1"},"reference-count":60,"publisher":"Sociedade Brasileira de Cardiologia","issue":"11","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo Com o aumento da preval\u00eancia das s\u00edndromes coronarianas cr\u00f4nicas, muitos pacientes com aterosclerose extensa apresentam angina n\u00e3o controlada, mesmo recebendo a terapia m\u00e9dica otimizada. Isso se aplica especialmente a pacientes que n\u00e3o s\u00e3o candidatos adequados \u00e0 revasculariza\u00e7\u00e3o cir\u00fargica ou percut\u00e2nea. Diversos tratamentos t\u00eam sido investigados para o manejo da angina pectoris e, nesse contexto, o redutor do seio coron\u00e1rio surgiu como uma op\u00e7\u00e3o terap\u00eautica promissora. Desde a d\u00e9cada de 1950, com o in\u00edcio da cirurgia de Beck, o seio venoso coron\u00e1rio tem sido um ponto focal de pesquisa em terapias anti-isqu\u00eamicas. Avan\u00e7os cient\u00edficos significativos foram alcan\u00e7ados no estreitamento do seio venoso nas \u00faltimas duas d\u00e9cadas. Gra\u00e7as \u00e0s melhorias tecnol\u00f3gicas em procedimentos minimamente invasivos e aos m\u00e9todos mais precisos de avalia\u00e7\u00e3o do fluxo sangu\u00edneo mioc\u00e1rdico, uma nova op\u00e7\u00e3o terap\u00eautica tornou-se dispon\u00edvel para pacientes que sofrem de angina refrat\u00e1ria e, possivelmente, de disfun\u00e7\u00e3o microvascular. Nesta revis\u00e3o, nosso objetivo \u00e9 examinar os principais conceitos relacionados \u00e0 angina pectoris e \u00e0 isquemia mioc\u00e1rdica, destacando o hist\u00f3rico, o racional fisiopatol\u00f3gico e os aspectos t\u00e9cnicos da redu\u00e7\u00e3o do seio coron\u00e1rio como terapia para angina refrat\u00e1ria. Al\u00e9m disso, exploraremos as evid\u00eancias cient\u00edficas das \u00faltimas d\u00e9cadas, bem como identificaremos lacunas existentes e delinearemos dire\u00e7\u00f5es futuras de pesquisa sobre esse tratamento emergente.<\/jats:p>","DOI":"10.36660\/abc.20250139","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:51:07Z","timestamp":1768924267000},"source":"Crossref","is-referenced-by-count":0,"title":["Redu\u00e7\u00e3o do Seio Coron\u00e1rio para Tratamento de Angina Refrat\u00e1ria: O que Aprendemos 70 Anos ap\u00f3s a Cirurgia de Beck?"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5740-9564","authenticated-orcid":false,"given":"Sara Del Vecchio","family":"Ziotti","sequence":"first","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3546-4166","authenticated-orcid":false,"given":"Luciana Oliveira Cascaes","family":"Dourado","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1107-2117","authenticated-orcid":false,"given":"Ranil de","family":"Silva","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute,  Inglaterra; Royal Brompton and Harefield Hospitals,  Inglaterra"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha","family":"Al-Lamee","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute,  Inglaterra; Imperial College Healthcare National Health Service (NHS) Trust,  Inglaterra"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[{"name":"The Carl and Edyth Lindner Center for Research and Education,  EUA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Antonio Machado","family":"Cesar","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Vicente","family":"Serrano Jr.","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Antonio Cunha","family":"Abizaid","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Henrique Wolff","family":"Gowdak","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"3","key":"ref1","first-page":"279","article-title":"Contemporary Management of Refractory Angina","volume":"11","author":"Lantz R","year":"2022","journal-title":"Interv Cardiol Clin."},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcin.2019.08.055","article-title":"Refractory Angina: From Pathophysiology to New Therapeutic Nonpharmacological Technologies","volume":"13","author":"Gallone G","year":"2020","journal-title":"JACC Cardiovasc Interv."},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.120.009002","article-title":"Therapeutic Approaches for the No-Option Refractory Angina Patient","volume":"14","author":"Povsic TJ","year":"2021","journal-title":"Circ Cardiovasc Interv."},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/eurheartj\/ehaa820","article-title":"Management of Refractory Angina: An Update","volume":"42","author":"Davies A","year":"2021","journal-title":"Eur Heart J."},{"key":"ref5","first-page":"123","article-title":"Prevalence of Angina Pectoris in the Brazilian Population from the Rose Questionnaire: Analysis of the National Health Survey, 2013","volume":"18","author":"Lotufo PA","year":"2015","journal-title":"Rev Bras Epidemiol"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.15420\/ecr.2016:26:1","article-title":"Management of Refractory Angina Pectoris","volume":"11","author":"Cheng K","year":"2016","journal-title":"Eur Cardiol."},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1378\/chest.13-2885","article-title":"OSA and Depression are Common and Independently Associated with Refractory Angina in Patients with Coronary Artery Disease","volume":"146","author":"Geovanini GR","year":"2014","journal-title":"Chest."},{"issue":"7","key":"ref8","article-title":"Depression, Cardiovascular Disease, and Female Gender: An Underestimated Triad","volume":"120","author":"Avila WS","year":"2023","journal-title":"Arq Bras Cardiol."},{"issue":"34","key":"ref9","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/eurheartj\/eht165","article-title":"Long-Term Survival in Patients with Refractory Angina","volume":"34","author":"Henry TD","year":"2013","journal-title":"Eur Heart J."},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/clc.22599","article-title":"A Prospective Study of Patients with Refractory Angina: Outcomes and the Role of High-Sensitivity Troponin T","volume":"40","author":"Poppi NT","year":"2017","journal-title":"Clin Cardiol."},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jtcvs.2014.06.032","article-title":"Historical Perspectives of The American Association for Thoracic Surgery: Claude S","volume":"149","author":"Theruvath TP","year":"2015","journal-title":"Beck (1894-1971). 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