{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:32:46Z","timestamp":1772253166271,"version":"3.50.1"},"reference-count":27,"publisher":"Sociedade Brasileira de Cardiologia","issue":"11","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  O fen\u00f4meno de n\u00e3o-refluxo \u00e9 uma complica\u00e7\u00e3o cr\u00edtica da interven\u00e7\u00e3o coron\u00e1ria percut\u00e2nea (ICP), especialmente em pacientes com doen\u00e7a do enxerto de veia safena (EVS). Identificar preditores de n\u00e3o-refluxo \u00e9 crucial para melhorar a estratifica\u00e7\u00e3o de risco. O \u00edndice aterog\u00eanico plasm\u00e1tico (IAP), calculado como log(triglicer\u00eddeos\/HDL-C), \u00e9 um marcador de aterosclerose e disfun\u00e7\u00e3o microvascular. No entanto, seu papel na predi\u00e7\u00e3o de n\u00e3o-refluxo durante interven\u00e7\u00f5es de EVS permanece incerto.  Objetivo  Este estudo teve como objetivo avaliar a associa\u00e7\u00e3o entre IAP e o fen\u00f4meno de n\u00e3o-refluxo em pacientes submetidos \u00e0 ICP para les\u00f5es de EVS apresentando infarto do mioc\u00e1rdio sem supradesnivelamento do segmento ST (IAMSSST).  M\u00e9todos  Este estudo retrospectivo de centro \u00fanico incluiu 287 pacientes submetidos a ICP para estenose significativa do EVS. Os pacientes foram categorizados em grupos com refluxo normal e n\u00e3o-refluxo, com base nos graus de fluxo TIMI (tromb\u00f3lise no infarto do mioc\u00e1rdio) p\u00f3s-ICP. Dados demogr\u00e1ficos, cl\u00ednicos, laboratoriais e angiogr\u00e1ficos basais foram extra\u00eddos. O IAP foi calculado utilizando a f\u00f3rmula logar\u00edtmica (TG\/HDL-C). An\u00e1lises de regress\u00e3o log\u00edstica foram realizadas para determinar os preditores independentes do n\u00e3o-refluxo. A signific\u00e2ncia estat\u00edstica foi estabelecida em p &lt; 0,05.  Resultados  O grupo n\u00e3o-refluxo era mais velho e apresentava maior preval\u00eancia de comorbidades, incluindo diabetes, fibrila\u00e7\u00e3o atrial, insufici\u00eancia card\u00edaca cr\u00f4nica, doen\u00e7a renal cr\u00f4nica e hist\u00f3rico de acidente vascular cerebral. Eles tamb\u00e9m apresentaram n\u00edveis mais baixos de HDL-C, n\u00edveis mais altos de triglicer\u00eddeos e, consequentemente, valores mais altos de IAP em compara\u00e7\u00e3o ao grupo com refluxo normal. A an\u00e1lise multivariada identificou EVS degenerado (OR: 4,65, p &lt; 0,001), presen\u00e7a de trombo (OR: 5,65, p &lt; 0,001), fra\u00e7\u00e3o de eje\u00e7\u00e3o do ventr\u00edculo esquerdo reduzida (OR: 0,927, p &lt; 0,001) e IAP elevado (OR: 3,141, p = 0,001) como preditores independentes de n\u00e3o-refluxo.  Conclus\u00e3o  O IAP elevado \u00e9 um fator de risco independente para n\u00e3o-refluxo em pacientes com IAMSSST submetidos a ICP para EVS, destacando seu papel potencial na estratifica\u00e7\u00e3o de risco precoce.<\/jats:p>","DOI":"10.36660\/abc.20250162","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:00:43Z","timestamp":1768921243000},"source":"Crossref","is-referenced-by-count":0,"title":["Valor Preditivo do \u00cdndice Aterog\u00eanico para N\u00e3o-Refluxo em Pacientes Submetidos \u00e0 ICP para Enxerto de Veia Safena na S\u00edndrome Coronariana Aguda"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1886-4715","authenticated-orcid":false,"given":"Onur","family":"Erdo\u011fan","sequence":"first","affiliation":[{"name":"University of Health Sciences,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cafer","family":"Pan\u00e7","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turquia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"22","key":"ref1","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1161\/hc4601.099487","article-title":"Global Burden of Cardiovascular Diseases: Part I: General Considerations, the Epidemiologic Transition, Risk Factors, and Impact of Urbanization","volume":"104","author":"Yusuf S","year":"2001","journal-title":"Circulation"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"917","DOI":"10.4065\/84.10.917","article-title":"Acute Coronary Syndromes: Diagnosis and Management, part I","volume":"84","author":"Kumar A","year":"2009","journal-title":"Mayo Clin 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