{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:12:15Z","timestamp":1780506735596,"version":"3.54.1"},"reference-count":50,"publisher":"Sociedade Brasileira de Cardiologia","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo A doen\u00e7a de Danon \u00e9 uma doen\u00e7a rara ligada ao cromossomo X, causada por variantes patog\u00eanicas ou provavelmente patog\u00eanicas no gene da prote\u00edna 2 da membrana associada ao lisossomo (LAMP2). Manifesta-se principalmente como cardiomiopatia hipertr\u00f3fica, miopatia, defici\u00eancia intelectual e retinopatia, sendo que os homens geralmente apresentam um fen\u00f3tipo mais grave e de in\u00edcio precoce. A fisiopatologia da doen\u00e7a de Danon est\u00e1 ligada \u00e0 autofagia defeituosa devido \u00e0 defici\u00eancia de LAMP2, levando ao ac\u00famulo de vac\u00faolos cheios de glicog\u00eanio dentro dos cardiomi\u00f3citos e outros tecidos. Isso resulta em hipertrofia card\u00edaca progressiva, anormalidades de condu\u00e7\u00e3o e eventual insufici\u00eancia card\u00edaca, frequentemente necessitando de transplante card\u00edaco. O envolvimento da musculatura esquel\u00e9tica \u00e9 comum em homens, enquanto o comprometimento cognitivo \u00e9 observado em ambos os sexos, embora mais prevalente em homens. O diagn\u00f3stico \u00e9 desafiador devido \u00e0 raridade da doen\u00e7a e \u00e0 apresenta\u00e7\u00e3o vari\u00e1vel, o que destaca a necessidade de uma abordagem multidisciplinar, incluindo testes gen\u00e9ticos para um diagn\u00f3stico definitivo. Os testes gen\u00e9ticos devem ser realizados somente ap\u00f3s aconselhamento gen\u00e9tico adequado. O diagn\u00f3stico diferencial deve ser considerado quando h\u00e1 suspeita de doen\u00e7a de Danon, dependendo dos sinais e sintomas, incluindo doen\u00e7as como a doen\u00e7a de Fabry, a s\u00edndrome PRKAG2, a doen\u00e7a de Pompe, entre outras. As estrat\u00e9gias de tratamento atuais focam no al\u00edvio dos sintomas, sendo o transplante card\u00edaco uma interven\u00e7\u00e3o crucial para casos avan\u00e7ados. Terapias emergentes, como a terapia g\u00eanica direcionada ao gene LAMP2, podem auxiliar na altera\u00e7\u00e3o da progress\u00e3o da doen\u00e7a. Esta revis\u00e3o oferece uma vis\u00e3o abrangente da doen\u00e7a de Danon, abordando suas manifesta\u00e7\u00f5es cl\u00ednicas, mecanismos subjacentes, desafios diagn\u00f3sticos e potenciais abordagens terap\u00eauticas para melhorar os resultados. Nosso objetivo \u00e9 aumentar o reconhecimento da doen\u00e7a de Danon para que a preven\u00e7\u00e3o de poss\u00edveis complica\u00e7\u00f5es e o diagn\u00f3stico precoce se tornem vi\u00e1veis, levando, em \u00faltima an\u00e1lise, a desfechos mais favor\u00e1veis para os pacientes.<\/jats:p>","DOI":"10.36660\/abc.20250186","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:47:41Z","timestamp":1780505261000},"source":"Crossref","is-referenced-by-count":0,"title":["Doen\u00e7a de Danon: Compreendendo o Papel das Variantes do LAMP2 na Miocardiopatia e no Envolvimento Multissist\u00eamico"],"prefix":"10.36660","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6036-5474","authenticated-orcid":false,"given":"Giovanna Napolitano Pereira","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  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NR","year":"1995","journal-title":"DNA Cell Biol"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1006\/bbrc.1995.2528","article-title":"An Alternatively Spliced form of the Human Lysosome-Associated Membrane Protein-2 Gene is Expressed in a Tissue-Specific Manner","volume":"215","author":"Konecki DS","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/j.1600-0854.2005.00337.x","article-title":"Unifying Nomenclature for the Isoforms of the Lysosomal Membrane Protein LAMP-2","volume":"6","author":"Eskelinen EL","year":"2005","journal-title":"Traffic"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00401-015-1385-4","article-title":"Danon Disease: A Phenotypic Expression of LAMP-2 Deficiency","volume":"129","author":"Endo Y","year":"2015","journal-title":"Acta 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X","year":"2021","journal-title":"Radiology"},{"issue":"7","key":"ref35","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1212\/WNL.33.7.873","article-title":"Lysosomal Glycogen Storage Disease without Acid Maltase Deficiency","volume":"33","author":"Riggs JE","year":"1983","journal-title":"Neurology"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1399-0004.2008.00971.x","article-title":"Cardioembolic Stroke in Danon disease","volume":"73","author":"Spinazzi M","year":"2008","journal-title":"Clin Genet"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/1474515111430928","article-title":"Depression and Health-Related Quality of Life in People with Coronary Heart Disease: A Systematic Review","volume":"11","author":"Dickens C","year":"2012","journal-title":"Eur J Cardiovasc Nurs"},{"issue":"9","key":"ref38","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1002\/ajmg.a.38320","article-title":"Psychiatric and Cognitive Characteristics of Individuals with Danon Disease (LAMP2 Gene Mutation)","volume":"173","author":"Yardeni M","year":"2017","journal-title":"Am J Med Genet A"},{"issue":"6","key":"ref39","first-page":"479","article-title":"Clinical Findings and Prognosis of Danon Disease. An Analysis of the Spanish Multicenter Danon Registry","volume":"72","author":"L\u00f3pez-Sainz \u00c1","year":"2019","journal-title":"Rev Esp Cardiol"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1001\/archopht.125.2.231","article-title":"Retinopathy in Danon Disease","volume":"125","author":"Schorderet DF","year":"2007","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/IAE.0000000000000736","article-title":"The Physiology of the Retinal Pigment Epithelium in Danon Disease","volume":"36","author":"Thompson DA","year":"2016","journal-title":"Retina"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1073\/pnas.1808618116","article-title":"LAMP-2B Regulates Human Cardiomyocyte Function by Mediating Autophagosome-Lysosome Fusion","volume":"116","author":"Chi C","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/aos.14478","article-title":"Pigmentary Retinopathy can Indicate the Presence of Pathogenic LAMP2 Variants Even in Somatic Mosaic Carriers with no Additional Signs of Danon Disease","volume":"99","author":"Kousal B","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"ref44","series-title":"LAMP2 Gene [Internet]","year":"2025"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"920390","DOI":"10.3389\/fgene.2022.920390","article-title":"Incomplete Penetrance and Variable Expressivity: From Clinical Studies to Population Cohorts","volume":"13","author":"Kingdom R","year":"2022","journal-title":"Front Genet"},{"key":"ref46","series-title":"Frontiers in Lysosomal Storage Diseases (LSD) Treatments","volume-title":"Danon Disease","author":"Bennett LL","year":"2023"},{"issue":"37","key":"ref47","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC Guidelines for the Management of Cardiomyopathies","volume":"44","author":"Arbelo E","year":"2023","journal-title":"Eur Heart J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijcard.2022.03.050","article-title":"Diagnosis and Management of Rare Cardiomyopathies in Adult and Paediatric Patients. 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