{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:51:30Z","timestamp":1781711490710,"version":"3.54.5"},"reference-count":60,"publisher":"Sociedade Brasileira de Cardiologia","issue":"12","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  A estimula\u00e7\u00e3o do sistema de condu\u00e7\u00e3o (ESC) surgiu como uma alternativa \u00e0 estimula\u00e7\u00e3o biventricular (EBV) para terapia de ressincroniza\u00e7\u00e3o card\u00edaca (TRC), com potenciais benef\u00edcios cl\u00ednicos e menores custos. O PhysioSync-HF \u00e9 um estudo multic\u00eantrico e randomizado que compara essas estrat\u00e9gias sob as perspectivas cl\u00ednica e econ\u00f4mica em pacientes com insufici\u00eancia card\u00edaca e fra\u00e7\u00e3o de eje\u00e7\u00e3o reduzida (ICFER).  Objetivo  Descrever a justificativa e o desenho da avalia\u00e7\u00e3o econ\u00f4mica baseada em ensaio cl\u00ednico incorporada ao estudo PhysioSync-HF.  M\u00e9todos  O estudo PhysioSync-HF incluiu 179 pacientes com seguimento de 1 ano. Os dados de custo do procedimento ser\u00e3o coletados utilizando a abordagem de custeio baseado em atividades e tempo. Os custos associados ao dispositivo, eventos cl\u00ednicos adversos e cuidados ambulatoriais durante o seguimento ser\u00e3o estimados por meio de m\u00e9todos de contabilidade baseados em recursos consumidos. M\u00e9todos apropriados ser\u00e3o empregados para tratar dados ausentes, e as an\u00e1lises estat\u00edsticas considerar\u00e3o a distribui\u00e7\u00e3o assim\u00e9trica das vari\u00e1veis de custo.  Resultados  O desfecho econ\u00f4mico prim\u00e1rio \u00e9 a diferen\u00e7a entre os grupos no custo m\u00e9dico direto total por paciente ao longo de 1 ano de seguimento (ESC vs. EBV). Os desfechos secund\u00e1rios incluem a decomposi\u00e7\u00e3o dos custos diretos em componentes e uma an\u00e1lise de impacto or\u00e7ament\u00e1rio que estima o efeito anual no sistema de sa\u00fade brasileiro se todos os pacientes eleg\u00edveis recebessem ESC em vez de EBV.  Conclus\u00e3o  Aproveitando um ensaio cardiovascular multic\u00eantrico para mensurar os custos da ESC em compara\u00e7\u00e3o \u00e0 EBV, esta avalia\u00e7\u00e3o econ\u00f4mica busca identificar oportunidades de redu\u00e7\u00e3o de custos que possam ampliar o acesso com equidade \u00e0 TRC para indiv\u00edduos com ICFER no Brasil, al\u00e9m de fornecer informa\u00e7\u00f5es relevantes para outros sistemas de sa\u00fade no mundo.  Registro do Ensaio  NCT05572736.<\/jats:p>","DOI":"10.36660\/abc.20250254","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:52:21Z","timestamp":1781707941000},"source":"Crossref","is-referenced-by-count":0,"title":["Estimula\u00e7\u00e3o do Sistema de Condu\u00e7\u00e3o Versus Estimula\u00e7\u00e3o Biventricular na Insufici\u00eancia Card\u00edaca Cr\u00f4nica: Protocolo para a An\u00e1lise Econ\u00f4mica do Estudo PhysioSync-HF"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6989-3079","authenticated-orcid":false,"given":"S\u00e9rgio R. 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