{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T19:04:08Z","timestamp":1788116648937,"version":"build-2803163510"},"reference-count":18,"publisher":"Sociedade Brasileira de Cardiologia","issue":"11","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  A S\u00edndrome da Taquicardia Postural Ortost\u00e1tica (POTS, do ingl\u00eas Postural Orthostatic Tachycardia Syndrome) \u00e9 uma disfun\u00e7\u00e3o auton\u00f4mica definida por sintomas de intoler\u00e2ncia ortost\u00e1tica, associada \u00e0 eleva\u00e7\u00e3o da frequ\u00eancia card\u00edaca at\u00e9 10 minutos ap\u00f3s assumir a posi\u00e7\u00e3o ortost\u00e1tica ou inclina\u00e7\u00e3o da cabe\u00e7a para cima, na aus\u00eancia de hipotens\u00e3o. Existem tr\u00eas fen\u00f3tipos de POTS (neurop\u00e1tica, hipovol\u00eamica e hiperadren\u00e9rgica) e todos resultam em taquicardia e altera\u00e7\u00e3o da perfus\u00e3o cerebral. A terapia farmacol\u00f3gica est\u00e1 indicada em alguns casos, mas ainda n\u00e3o foi aprovado um medicamento espec\u00edfico para essa condi\u00e7\u00e3o. Alguns estudos mostraram que a ivabradina, pode ser ben\u00e9fica, reduzindo a frequ\u00eancia card\u00edaca sem afetar a press\u00e3o arterial.  Objetivo  Avaliar a efic\u00e1cia e a seguran\u00e7a da ivabradina no tratamento da POTS.  M\u00e9todo  Revis\u00e3o sistem\u00e1tica com descritores \u201cIvabradina\u201d e \u201cS\u00edndrome da Taquicardia Postural Ortost\u00e1tica\u201d nas bases de dados PubMed, Scielo, LILACS e Google Scholar. Artigos agrupados e avaliados pela estrat\u00e9gia PICO.  Resultados  Identificados 52 artigos, sete foram inclu\u00eddos na revis\u00e3o e separados em prospectivos3 e retrospectivos.4 No total, 203 pacientes foram avaliados, sendo a maioria do sexo feminino. Houve redu\u00e7\u00e3o significativa da press\u00e3o arterial e melhora dos sintomas de intoler\u00e2ncia ortost\u00e1tica em todos os estudos e a maioria dos pacientes n\u00e3o relatou efeitos adversos, independentemente do fen\u00f3tipo de POTS do paciente.  Conclus\u00e3o  A ivabradina mostrou-se eficaz e segura na terap\u00eautica dos pacientes portadores de POTS.<\/jats:p>","DOI":"10.36660\/abc.20250347","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T13:57:57Z","timestamp":1767967077000},"source":"Crossref","is-referenced-by-count":1,"title":["Uso da Ivabradina na Terap\u00eautica de Pacientes Portadores da S\u00edndrome da Taquicardia Postural Ortost\u00e1tica (POTS): Uma Revis\u00e3o Sistem\u00e1tica"],"prefix":"10.36660","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8788-1311","authenticated-orcid":false,"given":"Ana Paula Giannella de","family":"Melo","sequence":"first","affiliation":[{"name":"Faculdade de Medicina do ABC,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6134-3654","authenticated-orcid":false,"given":"Miguel Ant\u00f4nio","family":"Moretti","sequence":"additional","affiliation":[{"name":"Faculdade de 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