{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:21:11Z","timestamp":1792038071103,"version":"4.4.0"},"reference-count":23,"publisher":"Sociedade Brasileira de Cardiologia","issue":"12","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  As associa\u00e7\u00f5es cl\u00ednicas e de imagem iniciais na arterite de Takayasu (AT) s\u00e3o pouco definidas.  Objetivos  Caracterizar as manifesta\u00e7\u00f5es iniciais, suas associa\u00e7\u00f5es e os resultados a longo prazo em uma coorte de pacientes com AT.  M\u00e9todos  Um estudo de coorte retrospectivo unic\u00eantrico (2000 a 2024) incluiu pacientes diagnosticados com AT. O n\u00edvel de signific\u00e2ncia foi definido em p&lt;0,05.  Resultados  Dos 203 pacientes identificados, 54 foram exclu\u00eddos devido a dados incompletos. A coorte final foi composta por 149 pacientes (89,9% do sexo feminino), com mediana de idade ao diagn\u00f3stico de 31 anos. Ao diagn\u00f3stico, 92,6% apresentavam sintomas. A claudica\u00e7\u00e3o dos membros superiores (36,2%) e inferiores (30,9%) foi frequente, juntamente com les\u00e3o vascular avan\u00e7ada, como estenose (85,9%) e oclus\u00f5es (52,3%). A claudica\u00e7\u00e3o dos membros superiores foi predita independentemente pela redu\u00e7\u00e3o dos pulsos nos membros superiores (OR=4,83; IC 95%=2,08-11,24; p=0,001) e pela oclus\u00e3o da art\u00e9ria subcl\u00e1via direita (OR=8,06; IC 95%=1,94-33,44; p=0,004). A claudica\u00e7\u00e3o dos membros inferiores foi prevista pela oclus\u00e3o da art\u00e9ria subcl\u00e1via direita (OR=6,65; IC 95%=2,05-21,61; p=0,002), espessamento da art\u00e9ria subcl\u00e1via direita (OR=5,12; IC 95%=1,18-22,71; p=0,029) e estenose da art\u00e9ria subcl\u00e1via esquerda (OR=2,71; IC 95%=1,21-60,56; p=0,016). Durante um acompanhamento mediano de 10 anos, apesar da remiss\u00e3o em 91,3% dos casos, houve aumento das comorbidades cardiovasculares e 26,8% dos pacientes necessitaram de cirurgia.  Conclus\u00f5es  A claudica\u00e7\u00e3o intermitente dos membros \u00e9 um importante indicador progn\u00f3stico de les\u00e3o radiol\u00f3gica avan\u00e7ada e atraso no diagn\u00f3stico. Isso \u00e9 refor\u00e7ado pela dissocia\u00e7\u00e3o a longo prazo entre alta remiss\u00e3o cl\u00ednica e doen\u00e7a vascular progressiva, o que exige monitoramento vigilante.<\/jats:p>","DOI":"10.36660\/abc.20250534","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T18:38:24Z","timestamp":1770316704000},"source":"Crossref","is-referenced-by-count":1,"title":["Explorando as Correla\u00e7\u00f5es entre as Manifesta\u00e7\u00f5es Cl\u00ednicas e Radiol\u00f3gicas Iniciais na Arterite de Takayasu"],"prefix":"10.36660","volume":"122","author":[{"given":"An\u00edsio Uchoa Leite","family":"Santana","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3682-4517","authenticated-orcid":false,"given":"Samuel Katsuyuki","family":"Shinjo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22636","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"7","key":"ref1","article-title":"Pathophysiology, Diagnosis, and Management of Takayasu Arteritis: A Review of Current Advances","volume":"15","author":"Bhandari S","year":"2023","journal-title":"Cureus"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1016\/S0167-5273(96)02813-6","article-title":"Angiographic Findings of Takayasu Arteritis: New Classification","volume":"54","author":"Hata A","year":"1996","journal-title":"Int J Cardiol"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1148\/radiographics.17.3.9153698","article-title":"Takayasu Arteritis: Protean Radiologic Manifestations and Diagnosis","volume":"17","author":"Matsunaga N","year":"1997","journal-title":"Radiographics"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/jmri.1880080221","article-title":"Takayasu Arteritis: MR Manifestations and Diagnosis of Acute and Chronic Phase","volume":"8","author":"Matsunaga N","year":"1998","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0377-1237(17)30505-1","article-title":"Clinical Profile of Takayasu's Arteritis","volume":"54","author":"Sharma SK","year":"1998","journal-title":"Med J Armed Forces India"},{"issue":"9","key":"ref6","article-title":"The Epidemiology and Clinical Manifestations of Takayasu Arteritis: A Descriptive Study of Case Reports","volume":"13","author":"Alnabwani D","year":"2021","journal-title":"Cureus"},{"key":"ref7","article-title":"Clinical Manifestations and Management of Takayasu Arteritis: A Single Center Pediatric Cohort","author":"Altaffer AL","year":"2023","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0250025","article-title":"Takayasu Arteritis: Prevalence and Clinical Presentation in Switzerland","volume":"16","author":"Gloor AD","year":"2021","journal-title":"PLoS One"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s10067-010-1496-1","article-title":"Takayasu's Arteritis: Clinical Features and Outcomes of 125 Patients in China","volume":"29","author":"Cong XL","year":"2010","journal-title":"Clin Rheumatol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/art.20922","article-title":"Takayasu's Arteritis: A Study of 104 Italian Patients","volume":"53","author":"Vanoli M","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1016\/S0167-5273(96)88780-8","article-title":"Current Status of Takayasu Arteritis in India","volume":"54","author":"Jain S","year":"1996","journal-title":"Int J Cardiol"},{"issue":"4","key":"ref12","first-page":"311","article-title":"Takayasu Arteritis May be Underdiagnosed in North America","volume":"11","author":"Sharma BK","year":"1995","journal-title":"Can J Cardiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF01744542","article-title":"Takayasu Arteritis in India","volume":"7","author":"Sharma BK","year":"1992","journal-title":"Heart Vessels Suppl"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF01744541","article-title":"Takayasu Arteritis in China: A Report of 530 Cases","volume":"7","author":"Zheng D","year":"1992","journal-title":"Heart Vessels Suppl"},{"issue":"1","key":"ref15","first-page":"S59","article-title":"Takayasu's Arteritis in Turkey - Clinical and Angiographic Features of 248 Patients","volume":"27","author":"Bicakcigil M","year":"2009","journal-title":"Clin Exp Rheumatol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0002-8703(77)80178-6","article-title":"Takayasu's Arteritis. 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