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Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  Estudos observacionais t\u00eam relacionado citocinas inflamat\u00f3rias a dist\u00farbios cardiometab\u00f3licos; no entanto, ainda n\u00e3o est\u00e1 claro se essas associa\u00e7\u00f5es refletem efeitos causais em sistemas org\u00e2nicos interconectados.  Objetivos  Este estudo de randomiza\u00e7\u00e3o mendeliana (RM) investiga a causalidade entre 91 citocinas inflamat\u00f3rias e disfun\u00e7\u00e3o multiorg\u00e2nica nos sistemas cardiovascular, renal e metab\u00f3lico na era da s\u00edndrome cardiovascular-renal-metab\u00f3lica (CKM).  M\u00e9todos  Foram obtidos instrumentos gen\u00e9ticos associados a 91 citocinas inflamat\u00f3rias do painel Olink Target Inflammation em 11 grupos de ascend\u00eancia europeia.A m\u00e9todo da foi considerado a principal an\u00e1lise, complementadas por an\u00e1lises de sensibilidade, incluindo os m\u00e9todos MR-Egger e da mediana ponderada.  Resultados  Os n\u00edveis de citocinas inflamat\u00f3rias previstos geneticamente mostraram amplas associa\u00e7\u00f5es causais em diversas caracter\u00edsticas relacionadas \u00e0 matriz extracelular (CKM). Especificamente, 31 citocinas foram associadas a desfechos cardiovasculares, 26 a caracter\u00edsticas renais, 10 a caracter\u00edsticas relacionadas \u00e0 obesidade e 21 a caracter\u00edsticas relacionadas ao diabetes, totalizando 60 citocinas com pelo menos uma associa\u00e7\u00e3o significativa. Notavelmente, FGF5 e IL6 emergiram como reguladores paradoxais, exercendo efeitos opostos em diferentes sistemas org\u00e2nicos, enquanto o MCSF foi consistentemente identificado como um amplificador de risco pan-vascular para doen\u00e7as cardiovasculares.  Conclus\u00f5es  Esta an\u00e1lise abrangente de RM revela uma heterogeneidade causal substancial nos efeitos das citocinas inflamat\u00f3rias nos sistemas cardiovascular, renal e metab\u00f3lico. Esses achados destacam a import\u00e2ncia cl\u00ednica da modula\u00e7\u00e3o inflamat\u00f3ria espec\u00edfica para cada tecido e contexto, apoiando o desenvolvimento de estrat\u00e9gias terap\u00eauticas de precis\u00e3o para a s\u00edndrome de CKM.<\/jats:p>","DOI":"10.36660\/abc.20250611","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:41:59Z","timestamp":1784576519000},"source":"Crossref","is-referenced-by-count":0,"title":["Investigando o Papel Causal das Citocinas Inflamat\u00f3rias no Desenvolvimento de Doen\u00e7as Cardiovasculares, Renais e Metab\u00f3licas"],"prefix":"10.36660","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0473-6077","authenticated-orcid":false,"given":"Mengjin","family":"Hu","sequence":"first","affiliation":[{"name":"Capital Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoting","family":"Gong","sequence":"additional","affiliation":[{"name":"Capital 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