{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T19:13:22Z","timestamp":1788203602476,"version":"build-2803163510"},"reference-count":43,"publisher":"Sociedade Brasileira de Cardiologia","issue":"8","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  O infarto do mioc\u00e1rdio (IM) continua sendo um importante problema de sa\u00fade global. Os pap\u00e9is da inflama\u00e7\u00e3o e do metabolismo lip\u00eddico na patog\u00eanese do IM t\u00eam atra\u00eddo mais aten\u00e7\u00e3o. O IM permanece como um importante problema de sa\u00fade global. O papel da inflama\u00e7\u00e3o e do metabolismo lip\u00eddico na patog\u00eanese do IM tem despertado crescente interesse. A raz\u00e3o entre neutr\u00f3filos e colesterol de lipoprote\u00edna de alta densidade (NHR) \u00e9 um novo biomarcador composto que integra marcadores de inflama\u00e7\u00e3o e do metabolismo lip\u00eddico, mas sua associa\u00e7\u00e3o com o IM n\u00e3o est\u00e1 clara.  Objetivos  Investigamos a associa\u00e7\u00e3o entre NHR e IM.  M\u00e9todos  Analisamos dados de 25.248 participantes eleg\u00edveis do NHANES entre 2005 e 2016. O hist\u00f3rico de IM foi determinado por meio de question\u00e1rios, e os valores de NHR foram obtidos a partir de exames laboratoriais. Modelos de regress\u00e3o log\u00edstica foram utilizados para avaliar as associa\u00e7\u00f5es entre NHR, contagem de neutr\u00f3filos e colesterol de lipoprote\u00edna de alta densidade (HDL-C) com as probabilidades de IM. A an\u00e1lise de spline c\u00fabica restrita (SCR) foi utilizada para avaliar poss\u00edveis associa\u00e7\u00f5es n\u00e3o lineares. An\u00e1lises de subgrupos e testes de intera\u00e7\u00e3o foram realizados para explorar a heterogeneidade potencial entre subgrupos demogr\u00e1ficos e cl\u00ednicos. An\u00e1lises de sensibilidade foram realizadas para avaliar a robustez dos principais achados. Um valor de p bicaudal &lt;0,05 foi considerado estatisticamente significativo.  Resultados  N\u00edveis mais elevados de NHR foram associados independentemente a maiores chances de IM. No modelo totalmente ajustado, os participantes no quartil mais alto de NHR apresentaram 49% mais chances de IM do que aqueles no quartil mais baixo. A contagem de neutr\u00f3filos isoladamente n\u00e3o apresentou associa\u00e7\u00e3o significativa com IM, enquanto os n\u00edveis de HDL-C apresentaram associa\u00e7\u00e3o inversa com IM. A SCR sugeriu uma associa\u00e7\u00e3o n\u00e3o linear modesta entre NHR e IM. Embora um ponto de inflex\u00e3o baseado em dados tenha sido identificado em 6,93, esse resultado deve ser interpretado como explorat\u00f3rio e descritivo, e n\u00e3o como um limiar clinicamente significativo. An\u00e1lises de subgrupos sugeriram uma associa\u00e7\u00e3o mais forte em mulheres, e a intera\u00e7\u00e3o por sexo foi estatisticamente significativa. An\u00e1lises de sensibilidade confirmaram a robustez desses achados.  Conclus\u00e3o  Nesta amostra ampla e representativa, n\u00edveis elevados de NHR foram associados de forma independente a maiores chances de IM, sugerindo que a NHR pode servir como um marcador epidemiol\u00f3gico potencialmente informativo para IM. Estudos prospectivos s\u00e3o necess\u00e1rios para determinar a causalidade e elucidar os mecanismos subjacentes.<\/jats:p>","DOI":"10.36660\/abc.20250718","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:18:16Z","timestamp":1788200296000},"source":"Crossref","is-referenced-by-count":0,"title":["Associa\u00e7\u00e3o entre a Rela\u00e7\u00e3o Neutr\u00f3filo-Colesterol HDL e Infarto do Mioc\u00e1rdio: Um Estudo Transversal"],"prefix":"10.36660","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6221-2638","authenticated-orcid":false,"given":"Youpeng","family":"Wang","sequence":"first","affiliation":[{"name":"Zhejiang University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8090-6609","authenticated-orcid":false,"given":"Qian","family":"Yin","sequence":"additional","affiliation":[{"name":"Zhejiang University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0910-5063","authenticated-orcid":false,"given":"Ying","family":"Lei","sequence":"additional","affiliation":[{"name":"Zhejiang University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5426-1698","authenticated-orcid":false,"given":"Juncang","family":"Duan","sequence":"additional","affiliation":[{"name":"Zhejiang University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22636","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"20","key":"ref1","first-page":"2529","article-title":"The Global Burden of Cardiovascular Diseases and Risk Factors: 2020 and Beyond","volume":"74","author":"Mensah GA","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"25","key":"ref2","first-page":"2982","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update from the 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