{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T19:46:31Z","timestamp":1782416791620,"version":"3.54.5"},"reference-count":47,"publisher":"Sociedade Brasileira de Cardiologia","issue":"5","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento: A menopausa representa uma importante transi\u00e7\u00e3o biol\u00f3gica na vida da mulher, definida pela cessa\u00e7\u00e3o da fun\u00e7\u00e3o ovariana e por uma redu\u00e7\u00e3o acentuada dos n\u00edveis de estrog\u00eanio. Embora suas consequ\u00eancias sist\u00eamicas, incluindo osteoporose e aumento do risco cardiovascular, estejam bem estabelecidas, seu impacto na sa\u00fade oral permanece insuficientemente reconhecido tanto por profissionais m\u00e9dicos quanto odontol\u00f3gicos.  Objetivo: Examinar a influ\u00eancia da menopausa na sa\u00fade oral das mulheres, enfatizando os principais mecanismos fisiopatol\u00f3gicos, as manifesta\u00e7\u00f5es cl\u00ednicas e as estrat\u00e9gias interdisciplinares de preven\u00e7\u00e3o e manejo.  M\u00e9todos: Foi realizada uma revis\u00e3o narrativa utilizando artigos recuperados da base de dados PubMed, publicados entre 2000 e 2025. Foram utilizados os seguintes descritores: \"menopause\", \"oral health\", \"hormonal changes\", \"cardiovascular disease\", \"xerostomia\", \"salivary glands\", \"periodontitis\" e \"postmenopausal women\".  Resultados: As altera\u00e7\u00f5es hormonais durante a menopausa est\u00e3o associadas a diversas manifesta\u00e7\u00f5es orais, incluindo xerostomia, s\u00edndrome da ard\u00eancia bucal, doen\u00e7a periodontal e altera\u00e7\u00f5es do paladar. A defici\u00eancia de estrog\u00eanio parece contribuir para a redu\u00e7\u00e3o do fluxo salivar, atrofia da mucosa e aumento da resposta inflamat\u00f3ria nos tecidos periodontais. Evid\u00eancias emergentes tamb\u00e9m sugerem uma associa\u00e7\u00e3o entre a sa\u00fade oral na menopausa e a doen\u00e7a cardiovascular, entre outras condi\u00e7\u00f5es sist\u00eamicas. No entanto, persistem lacunas importantes no conhecimento quanto ao manejo cl\u00ednico e ao cuidado interdisciplinar de mulheres na menopausa.  Conclus\u00e3o: A sa\u00fade oral durante a menopausa reflete uma intera\u00e7\u00e3o complexa de fatores hormonais, sist\u00eamicos e comportamentais. Diante do aumento da expectativa de vida em todo o mundo, programas de educa\u00e7\u00e3o e pesquisa em sa\u00fade oral devem priorizar esse tema. O fortalecimento da conscientiza\u00e7\u00e3o e a promo\u00e7\u00e3o da colabora\u00e7\u00e3o multidisciplinar s\u00e3o essenciais para melhorar os desfechos em sa\u00fade de mulheres na meia-idade.<\/jats:p>","DOI":"10.36660\/abc.20250737","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:51:38Z","timestamp":1782413498000},"source":"Crossref","is-referenced-by-count":0,"title":["A Silenciosa Transi\u00e7\u00e3o da Menopausa: A Interse\u00e7\u00e3o entre Gl\u00e2ndulas Salivares, Condi\u00e7\u00e3o da Cavidade Oral e Sa\u00fade Cardiovascular"],"prefix":"10.36660","volume":"123","author":[{"given":"Silvia Vanessa","family":"Louren\u00e7o","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil; Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5328-0937","authenticated-orcid":false,"given":"Giovanna Piacenza","family":"Florezi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil; Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cibele","family":"Pelissari","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil; Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio Carneiro","family":"Hojaij","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pinhata","family":"Otoch","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio Franchini","family":"Ramires","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22636","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3390\/ijerph19010253","article-title":"Changes in the Oral Cavity in Menopausal Women-A Narrative Review","volume":"19","author":"Ciesielska A","year":"2021","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"ref2","first-page":"135","article-title":"Menopause and Oral Health: Clinical Implications and Preventive Strategies","volume":"15","author":"Shrivastava S","year":"2024","journal-title":"J Midlife Health"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1093\/humrep\/16.9.2014","article-title":"The Role of Genetic Factors in Age at Natural Menopause","volume":"16","author":"Bruin JP","year":"2001","journal-title":"Hum Reprod"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.mcna.2015.01.006","article-title":"Menopause","volume":"99","author":"Takahashi TA","year":"2015","journal-title":"Med Clin North Am"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15004","DOI":"10.1038\/nrdp.2015.4","article-title":"Menopause","volume":"1","author":"Davis SR","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/13697137.2025.2501255","article-title":"REDLINC: Two Decades of Collaborative Insights Into Menopause and Women's Health in Latin America","volume":"28","author":"Tserotas K","year":"2025","journal-title":"Climacteric"},{"issue":"19","key":"ref7","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1016\/j.cell.2023.08.016","article-title":"Menopause-Biology, Consequences, Supportive Care, and Therapeutic Options","volume":"186","author":"Davis SR","year":"2023","journal-title":"Cell"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqad079","article-title":"Estrogen and the Vascular Endothelium: The Unanswered Questions","volume":"164","author":"SenthilKumar G","year":"2023","journal-title":"Endocrinology"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/er.2007-0001","article-title":"The Complex Role of Estrogens in Inflammation","volume":"28","author":"Straub RH","year":"2007","journal-title":"Endocr Rev"},{"issue":"2","key":"ref10","first-page":"101","article-title":"Impact of Menopausal Duration on Salivary Flow Rate, Tooth Loss, and Oral Health-Related Quality of Life in Indian Communities","volume":"14","author":"Krupa NC","year":"2023","journal-title":"J Midlife Health"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0378-5122(96)82008-1","article-title":"Oral Complaints Related to Menopause","volume":"24","author":"Ben Aryeh H","year":"1996","journal-title":"Maturitas"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1400640","DOI":"10.3389\/fendo.2024.1400640","article-title":"Sex Steroid Hormones: An Overlooked Yet Fundamental Factor in Oral Homeostasis in Humans","volume":"15","author":"Ulloa PEC","year":"2024","journal-title":"Front Endocrinol"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.maturitas.2009.02.009","article-title":"The Menopause and Oral Health","volume":"63","author":"Meurman JH","year":"2009","journal-title":"Maturitas"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s40496-020-00257-3","article-title":"The Buffalo OsteoPerio Studies: Summary of our Findings and the Unique Contributions of Robert J","volume":"7","author":"Wactawski-Wende J","year":"2020","journal-title":"Genco, DDS, PhD. 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