{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T18:01:28Z","timestamp":1784743288141,"version":"3.55.0"},"reference-count":28,"publisher":"Sociedade Brasileira de Cardiologia","issue":"5","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento: O valor progn\u00f3stico da mensura\u00e7\u00e3o do escore de c\u00e1lcio das art\u00e9rias coron\u00e1rias (CAC) na doen\u00e7a arterial coron\u00e1ria (DAC) n\u00e3o obstrutiva (definida como estenose &lt; 50%) n\u00e3o est\u00e1 suficientemente descrito.  Objetivos: Investigar a associa\u00e7\u00e3o entre a mensura\u00e7\u00e3o do CAC, fatores de risco cardiovascular e desfechos cl\u00ednicos em pacientes com DAC n\u00e3o obstrutiva.  M\u00e9todos: Ao todo, 2.509 pacientes foram submetidos \u00e0 angiotomografia coronariana (angioTC) e acompanhados por 8,9 \u00b1 2,6 anos. Conforme o CAD-RADS\u2122 2.0, a carga de placa foi classificada em ausente, leve, moderada e alta\/muito alta. O desfecho prim\u00e1rio foi um composto de mortalidade por todas as causas, s\u00edndrome coronariana aguda\/infarto agudo do mioc\u00e1rdio e acidente vascular encef\u00e1lico. A signific\u00e2ncia estat\u00edstica foi estabelecida em 5%.  Resultados: O escore de CAC foi 0 em 45,4% dos pacientes, 1-99 em 36,6% e \u2265 100 em 18,0%. Correspondentemente, 38,3% dos pacientes n\u00e3o apresentavam les\u00f5es coronarianas, 38,5% apresentavam les\u00f5es leves, 14,1% les\u00f5es moderadas e 9,2% les\u00f5es altas\/muito altas. Entre os pacientes com CAC = 0, a aus\u00eancia de les\u00f5es coronarianas predominou (81,2%), enquanto foi rara entre aqueles com CAC \u2265 100. O desfecho prim\u00e1rio ocorreu em 4,9% dos pacientes, predominantemente impulsionado pela mortalidade por todas as causas. Entre os 396 pacientes com angioTC coronariana seriada (intervalo m\u00e9dio: 6,5 \u00b1 2,6 anos), a progress\u00e3o do CAC (&gt; 2,5 de aumento com base no m\u00e9todo da raiz quadrada) foi observada em 41,9%. A carga de placa aumentou em paralelo. O escore de CAC apresentou associa\u00e7\u00e3o positiva com a carga de placa e com fatores de risco cardiovascular.  Conclus\u00f5es: Na DAC n\u00e3o obstrutiva, o CAC est\u00e1 presente em mais da metade dos pacientes e est\u00e1 associado tanto \u00e0 carga de placa quanto aos fatores de risco cardiovascular. A incid\u00eancia do desfecho prim\u00e1rio aumenta proporcionalmente \u00e0 carga de fatores de risco e aos n\u00edveis de CAC. O CAC e a carga de placa progridem concomitantemente ao longo do tempo, sustentando o papel do CAC como marcador substituto da progress\u00e3o da aterosclerose subcl\u00ednica.<\/jats:p>","DOI":"10.36660\/abc.20250772","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:07:44Z","timestamp":1784740064000},"source":"Crossref","is-referenced-by-count":0,"title":["Escore de C\u00e1lcio das Art\u00e9rias Coron\u00e1rias, Fatores de Risco e Desfechos Cl\u00ednicos na Doen\u00e7a Arterial Coronariana N\u00e3o Obstrutiva: Um Estudo de Seguimento de Longo Prazo"],"prefix":"10.36660","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2451-5570","authenticated-orcid":false,"given":"Prot\u00e1sio Lemos Da","family":"Luz","sequence":"first","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  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Vicente","family":"Serrano Jr.","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Carlos Palandri","family":"Chagas","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Rochitte","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0964-6222","authenticated-orcid":false,"given":"Marco 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