{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:05:24Z","timestamp":1785175524442,"version":"3.55.0"},"reference-count":40,"publisher":"Sociedade Brasileira de Cardiologia","issue":"6","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento: Os capsinoides (Cap) s\u00e3o compostos bioativos com propriedades termog\u00eanicas capazes de promover altera\u00e7\u00f5es fisiol\u00f3gicas e auxiliar na digest\u00e3o, podendo influenciar a perda de gordura na obesidade. No entanto, seus efeitos sobre o tecido card\u00edaco permanecem pouco esclarecidos.  Objetivos: Este estudo investigou os efeitos da administra\u00e7\u00e3o cr\u00f4nica de Cap sobre a contratilidade e a morfologia card\u00edaca em ratos obesos (Ob) induzidos por uma dieta hiperlip\u00eddica (DHL) saturada.  M\u00e9todos: Ratos Wistar machos foram distribu\u00eddos em grupos alimentados com dieta padr\u00e3o (DP) ou DHL por 19 semanas. Ap\u00f3s esse per\u00edodo, os animais foram redistribu\u00eddos em Controle (C), Obeso (Ob) e Obeso suplementado com capsinoides (ObCap). O grupo ObCap recebeu Cap por gavagem orog\u00e1strica (10 mg\/kg). Foram realizadas avalia\u00e7\u00f5es nutricionais, perfil diet\u00e9tico, an\u00e1lises histol\u00f3gicas, comorbidades e avalia\u00e7\u00f5es card\u00edacas. O n\u00edvel de signific\u00e2ncia adotado foi de 5% para todos os testes.  Resultados: Os dep\u00f3sitos de gordura e a adiposidade total foram maiores nos animais Ob em compara\u00e7\u00e3o ao grupo C, sem diferen\u00e7as entre Ob e ObCap. Altera\u00e7\u00f5es metab\u00f3licas, hormonais e lip\u00eddicas foram observadas entre Ob e ObCap. N\u00e3o foram detectadas diferen\u00e7as na morfometria card\u00edaca entre os grupos. O grupo ObCap apresentou redu\u00e7\u00e3o na fra\u00e7\u00e3o de encurtamento em compara\u00e7\u00e3o ao Ob. Quanto ao tempo de encurtamento, os animais Ob apresentaram redu\u00e7\u00e3o em rela\u00e7\u00e3o ao C, enquanto o grupo ObCap apresentou aumento em rela\u00e7\u00e3o ao Ob.  Conclus\u00e3o: O tratamento com Cap n\u00e3o preveniu o ac\u00famulo excessivo de gordura nem melhorou os par\u00e2metros metab\u00f3licos na obesidade. Al\u00e9m disso, prejudicou a contratilidade dos cardiomi\u00f3citos.<\/jats:p>","DOI":"10.36660\/abc.20250865","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:44:31Z","timestamp":1785174271000},"source":"Crossref","is-referenced-by-count":0,"title":["O Tratamento com Capsinoides Promove Redu\u00e7\u00e3o da Contratilidade dos Cardiomi\u00f3citos na Obesidade sem Modular Positivamente Par\u00e2metros Metab\u00f3licos"],"prefix":"10.36660","volume":"123","author":[{"given":"Kiany","family":"Miranda","sequence":"first","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e9ssia Cristina Carvalho","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janete Corr\u00eaa","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Furtado","family":"Domingos","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiane Merigueti","family":"Nunes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Martins","family":"Simmer","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Sesana","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Politi","family":"Okoshi","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-8277","authenticated-orcid":false,"given":"Danilo Sales","family":"Bocalini","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4049-4418","authenticated-orcid":false,"given":"Ana Paula","family":"Lima-Leopoldo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-2671","authenticated-orcid":false,"given":"Andr\u00e9 Soares","family":"Leopoldo","sequence":"additional","affiliation":[{"name":"Universidade 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