{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:17:38Z","timestamp":1787030258078,"version":"build-2736575974"},"reference-count":22,"publisher":"Sociedade Brasileira de Cardiologia","issue":"6","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  A maior parte das evid\u00eancias atuais sobre doen\u00e7a valvar card\u00edaca (DVC) vem de pa\u00edses de alta renda. O acesso ao tratamento e o impacto da DVC na qualidade de vida podem variar substancialmente entre pa\u00edses, principalmente devido a diferen\u00e7as socioecon\u00f4micas.  Objetivo  Este estudo teve como objetivo estimar a carga de DVC e sua associa\u00e7\u00e3o com mortalidade em um pa\u00eds de renda m\u00e9dia.  M\u00e9todos  Inclu\u00edmos participantes da coorte ELSA-Brasil que realizaram ecocardiograma transtor\u00e1cico na linha de base (3.267 participantes; 1.539 homens; idade m\u00e9dia de 60,6 \u00b1 8,8 anos) em seis estados brasileiros. Os participantes foram categorizados em tr\u00eas grupos \u2013 sem DVC, DVC m\u00ednima\/leve e DVC moderada\/grave \u2013 e suas caracter\u00edsticas e fatores associados foram analisados. Valores de p &lt; 0,05 foram considerados estatisticamente significativos.  Resultados  Entre todos os participantes, 2,4% apresentavam DVC moderada\/grave (incluindo sete participantes com pr\u00f3tese valvar) e 43,6% apresentavam DVC m\u00ednima\/leve. A DVC moderada\/grave mais prevalente foi a regurgita\u00e7\u00e3o mitral, seguida pelas regurgita\u00e7\u00f5es a\u00f3rtica e tric\u00faspide, com 56 participantes (86%) apresentando regurgita\u00e7\u00e3o valvar isolada. A DVC moderada\/grave foi mais comum em indiv\u00edduos mais velhos e esteve associada a maior preval\u00eancia da maioria das comorbidades cardiovasculares, por\u00e9m a menores taxas de obesidade. Tamb\u00e9m se associou a maior remodelamento card\u00edaco e pior fun\u00e7\u00e3o sist\u00f3lica, com varia\u00e7\u00f5es fenot\u00edpicas conforme a valva acometida. A DVC moderada\/grave esteve associada a maior mortalidade em 10 anos (HR: 3,7; IC 95% [2,17\u20136,31]), independentemente de idade, sexo e hipertens\u00e3o.  Conclus\u00e3o  A DVC \u00e9 comum entre adultos em uma coorte comunit\u00e1ria de um pa\u00eds de renda m\u00e9dia e aumenta com a idade. Participantes com DVC moderada\/grave apresentaram maior carga de comorbidades, remodelamento card\u00edaco mais acentuado, pior fun\u00e7\u00e3o sist\u00f3lica e redu\u00e7\u00e3o substancial da sobrevida em longo prazo.<\/jats:p>","DOI":"10.36660\/abc.20260060","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:42:26Z","timestamp":1784911346000},"source":"Crossref","is-referenced-by-count":2,"title":["Epidemiologia e Mortalidade da Doen\u00e7a Valvar Card\u00edaca em Adultos Brasileiros: Achados da Coorte ELSA-Brasil"],"prefix":"10.36660","volume":"123","author":[{"given":"Guilia Bevilacqua","family":"Schmitz","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Gatti","family":"Pianca","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  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Santiago","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil; Hospital de Cl\u00ednicas de Porto Alegre,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22636","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.mayocp.2018.12.035","article-title":"Burden of Valvular Heart Diseases in Hispanic\/Latino Individuals in the United States: The Echocardiographic Study of Latinos","volume":"94","author":"Rubin J","year":"2019","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0002-9149(98)01064-9","article-title":"Prevalence and Clinical Determinants of Mitral, Tricuspid, and Aortic Regurgitation (the Framingham Heart Study)","volume":"83","author":"Singh JP","year":"1999","journal-title":"Am J 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