{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:01:08Z","timestamp":1784653268351,"version":"3.55.0"},"reference-count":26,"publisher":"Sociedade Brasileira de Cardiologia","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento: A s\u00edndrome metab\u00f3lica (SM) permanece incompletamente caracterizada na vasculite associada a anticorpos anticitoplasma de neutr\u00f3filos (VAA). Este estudo teve como objetivo determinar a preval\u00eancia de SM em pacientes com VAA e identificar fatores associados \u00e0 sua presen\u00e7a.  M\u00e9todos: Este estudo transversal, unic\u00eantrico, incluiu 62 pacientes com VAA (42 com granulomatose com poliangiite, 15 com granulomatose eosinof\u00edlica com poliangiite e cinco com poliangiite microsc\u00f3pica) em acompanhamento regular em um hospital terci\u00e1rio de refer\u00eancia. Os pacientes foram pareados por idade e sexo com 53 controles. A SM foi definida de acordo com os crit\u00e9rios do National Cholesterol Education Program Adult Treatment Panel III. A signific\u00e2ncia estat\u00edstica foi padronizada em p &lt; 0,05.  Resultados: A mediana de idade dos pacientes foi de 56,1 anos (intervalo interquartil, 45,6-65,5); 53,2% eram mulheres e 85,5% eram brancos. A preval\u00eancia de SM foi significativamente maior no grupo VAA do que nos controles (43,5% vs 13,2%; p = 0,001). Diabetes melito, hipertens\u00e3o arterial sist\u00eamica e hist\u00f3ria familiar de doen\u00e7a cardiovascular foram mais frequentes entre os pacientes com VAA, enquanto o \u00edndice de massa corporal (IMC) e a inatividade f\u00edsica n\u00e3o diferiram entre os grupos. Na an\u00e1lise multivariada, SM (odds ratio [OR], 4,52; intervalo de confian\u00e7a de 95% [IC95%], 1,66-12,27; p = 0,003) e hist\u00f3ria familiar de doen\u00e7a cardiovascular (OR, 3,81; IC95%, 1,09-13,34; p &lt; 0,05) estiveram independentemente associadas \u00e0 VAA. Entre os pacientes com VAA, n\u00e3o foram observadas diferen\u00e7as entre aqueles com e sem SM quanto ao subtipo de VAA, medidas antropom\u00e9tricas, atividade da doen\u00e7a, hist\u00f3ria familiar, inatividade f\u00edsica ou tratamento atual. Em an\u00e1lise multivariada restrita aos pacientes com VAA, a SM esteve independentemente associada ao sexo masculino (OR, 11,43; IC95%, 2,81-46,52; p = 0,001) e a maior IMC (OR, 1,13; IC95%, 1,02-1,25; p = 0,022).  Conclus\u00f5es: A SM apresentou alta preval\u00eancia entre pacientes com VAA e esteve associada ao sexo masculino e a maior IMC, contribuindo para um perfil de risco cardiometab\u00f3lico desfavor\u00e1vel nesta coorte unic\u00eantrica.<\/jats:p>","DOI":"10.36660\/abc.20260076","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:01:38Z","timestamp":1784649698000},"source":"Crossref","is-referenced-by-count":0,"title":["Fatores Associados \u00e0 Alta Preval\u00eancia de S\u00edndrome Metab\u00f3lica em Vasculite Associada a Anticorpos Anticitoplasma de Neutr\u00f3filos"],"prefix":"10.36660","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1041-0115","authenticated-orcid":false,"given":"Marina Lamas","family":"Figueredo","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  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