{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:54:31Z","timestamp":1791914071115,"version":"4.3.4"},"reference-count":19,"publisher":"Sociedade Brasileira de Cardiologia","issue":"9","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Bras. Cardiol."],"abstract":"<jats:p>Resumo  Fundamento  A ectasia da art\u00e9ria coronariana (EAC) \u00e9 caracterizada pela dilata\u00e7\u00e3o anormal das art\u00e9rias coron\u00e1rias e est\u00e1 associada \u00e0 disfun\u00e7\u00e3o endotelial e \u00e0 inflama\u00e7\u00e3o sist\u00eamica. O \u00cdndice de Ativa\u00e7\u00e3o e Estresse Endotelial (EASIX) surgiu como um novo biomarcador que reflete a ativa\u00e7\u00e3o endotelial e o estresse inflamat\u00f3rio.  Objetivos  Este estudo teve como objetivo avaliar a associa\u00e7\u00e3o entre a pontua\u00e7\u00e3o EASIX e a presen\u00e7a de EAC.  M\u00e9todos  Um total de 300 pacientes submetidos a angiografia coron\u00e1ria. Os dados coletados entre julho de 2018 e dezembro de 2025 foram analisados retrospectivamente. O estudo foi delineado como um estudo caso-controle. Os pacientes foram divididos em dois grupos de acordo com a presen\u00e7a de EAC (150 pacientes com EAC e 150 controles). O escore EASIX foi calculado utilizando a seguinte f\u00f3rmula:    EASIX =  LDH  \u00d7  Creatinina  \/  Plaquetas. A an\u00e1lise da curva ROC (Receiver Operating Characteristic) foi realizada para determinar o valor preditivo do EASIX para EAC. A an\u00e1lise estat\u00edstica do \u00edndice de Youden foi realizada para avaliar o poder diagn\u00f3stico da an\u00e1lise ROC e calcular o valor de corte ideal. Um valor de p &lt; 0,05 foi considerado estatisticamente significativo.  Resultados  Os pacientes com EAC apresentaram pontua\u00e7\u00e3o EASIX significativamente maior em compara\u00e7\u00e3o com os controles (1,46 \u00b1 0,33 vs. 0,98 \u00b1 0,74). Na an\u00e1lise ROC, o escore EASIX foi de 72% sensibilidade e 58% especificidade quando o valor de corte para EASIX \u22650,74 (AUC=0,688, IC 95%:0,618-0,759, p&lt;0,001). Na an\u00e1lise de regress\u00e3o log\u00edstica multivari\u00e1vel, o escore EASIX foi identificado como um preditor independente de EAC (OR = 2,12, IC 95%: 1,35\u20133,34, p = 0,001).  Conclus\u00e3o  O escore EASIX foi associado de forma independente \u00e0 presen\u00e7a de EAC e demonstrou capacidade discriminativa moderada.<\/jats:p>","DOI":"10.36660\/abc.20260242","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:39:38Z","timestamp":1791913178000},"source":"Crossref","is-referenced-by-count":0,"title":["Rela\u00e7\u00e3o entre Ativa\u00e7\u00e3o Endotelial e \u00cdndice de Estresse e Ectasia da Art\u00e9ria Coronariana"],"prefix":"10.36660","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-5727","authenticated-orcid":false,"given":"Cihan","family":"Aydin","sequence":"first","affiliation":[{"name":"Tekirdag Nam\u0131k Kemal University","place":["Tekirdag, Turquia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-6411","authenticated-orcid":false,"given":"H\u00fcseyin","family":"Orta","sequence":"additional","affiliation":[{"name":"Tekirdag Nam\u0131k Kemal University","place":["Tekirdag, Turquia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8322-3514","authenticated-orcid":false,"given":"Aykut","family":"Demirkiran","sequence":"additional","affiliation":[{"name":"Tekirdag Nam\u0131k Kemal University","place":["Tekirdag, Turquia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0791-1248","authenticated-orcid":false,"given":"Nadir","family":"Emlek","sequence":"additional","affiliation":[{"name":"Recep Tayyip Erdo\u011fan University","place":["Rize, Turquia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22636","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1136\/hrt.54.4.392","article-title":"Coronary Artery Ectasia. 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