{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T22:21:55Z","timestamp":1768861315088,"version":"3.49.0"},"reference-count":69,"publisher":"Farmarus Print Media","content-domain":{"domain":["rusalljournal.ru"],"crossmark-restriction":false},"short-container-title":["Russian Journal of Allergy"],"abstract":"<jats:p>AIMS: To evaluate the antiallergic activity of an aqueous dispersion of fullerene C60 (ADF) and its safety in preclinical studies.\r\nMATERIALS AND METHODS: Food allergy was induced in BALB\/c mice by ovalbumin. ADF was administered intragastrically in different regimens. Specific IgE, Th2 cytokines, body weight, diarrhea, and jejunal histology were assessed. Allergenicity was tested in mice and guinea pigs using standard hypersensitivity assays, and immunotoxicity was evaluated in humoral, cellular, and phagocytic immunity models.\r\nRESULTS: ADF reduced OVA-specific IgE, IL-4 and IL-5, alleviated diarrhea, and supported weight gain. Histology showed decreased eosinophilia in the jejunum. No allergenic or immunotoxic effects were detected in preclinical tests.<\/jats:p>","DOI":"10.36691\/rja17060","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:25:08Z","timestamp":1768814708000},"update-policy":"https:\/\/doi.org\/10.36691\/crossmarkpolicy2021","source":"Crossref","is-referenced-by-count":0,"title":["Study of antiallergic properties and toxicity of aqueous dispersion of fullerene C60 on laboratory animals"],"prefix":"10.36691","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8703-5686","authenticated-orcid":false,"given":"Renata A.","family":"Kurmasheva","sequence":"additional","affiliation":[{"name":"\u0413\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043d\u0430\u0443\u0447\u043d\u044b\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0418\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0438\u043c\u043c\u0443\u043d\u043e\u043b\u043e\u0433\u0438\u0438\u00bb"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-6499","authenticated-orcid":false,"given":"Nadezda N.","family":"Shershakova","sequence":"additional","affiliation":[{"name":"National Research Center \u2014 Institute of Immunology Federal Medico-Biological Agency"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-5380","authenticated-orcid":false,"given":"Larisa V.","family":"Mikhina","sequence":"additional","affiliation":[{"name":"Research Center for Toxicology and Hygienic Regulation of Biological Products \u2014 Branch of the National Research Center \u2014 Institute of Immunology Federal Medico-Biological Agency"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0981-5540","authenticated-orcid":false,"given":"Elena N.","family":"Baraboshkina","sequence":"additional","affiliation":[{"name":"National Research Center \u2014 Institute of Immunology Federal Medico-Biological Agency"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa A.","family":"Eremenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena I.","family":"Sokolova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6822-3409","authenticated-orcid":false,"given":"Evgeny A.","family":"Turetskiy","sequence":"additional","affiliation":[{"name":"NRC Institute of Immunology FMBA of Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-6090","authenticated-orcid":false,"given":"Denis S.","family":"Gorshenin","sequence":"additional","affiliation":[{"name":"National Research Center \u2014 Institute of Immunology Federal Medico-Biological Agency"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg Yu.","family":"Kamishnikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8297-579X","authenticated-orcid":false,"given":"Sergei M.","family":"Andreev","sequence":"additional","affiliation":[{"name":"National Research Center \u2013 Institute of Immunology Federal Medical-Biological Agency of Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4826-7092","authenticated-orcid":false,"given":"Nikolay M.","family":"Onatsky","sequence":"additional","affiliation":[{"name":"Research Center for Toxicology and Hygienic Regulation of Biological Products \u2014 Branch of the National Research Center \u2014 Institute of Immunology Federal Medico-Biological Agency"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4961-9640","authenticated-orcid":false,"given":"Musa R.","family":"Khaitov","sequence":"additional","affiliation":[{"name":"National Research Center \u2014 Institute of Immunology Federal Medico-Biological Agency"},{"name":"The Russian National Research Medical University named after N.I. 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