{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:12:09Z","timestamp":1789197129761,"version":"build-2803163510"},"reference-count":32,"publisher":"ALUNA","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Aim: To study the role of certain neurotransmitters (brain-derived neurotrophic factor (BDNF), 5-hydroxytryptamine (5-HT)), metalloenzymes (matrix met\u00acalloproteinase-9) (MMP-9) and hormones (ghrelin) in the pathogenesis of mental disorders associated with stress under the impact of traumatic events. \nMaterials and methods: We conducted a systematic search of major electronic medical databases published before October 1, 2022. Such keywords as (post-traumatic stress disorder OR PTSD), (Brain-derived neurotrophic factor OR BDNF), (matrix metalloproteinase-9 OR MMP-9), (serotonin OR 5-HT), ghrelin, melatonin identified relevant studies. All articles were reviewed, including original studies, systematic reviews and meta-analyses. \nConclusions: Unfortunately, the imbalance of neurotransmitter systems of the brain remains not fully understood under such a condition at this stage of world science development. Their role remains unclear both during the immediate exposure to the stress factor and in the remote period. Therefore, under\u00acstanding the mechanisms underlying the systemic consequences of PTSD is crucial for the development of prediction models and timely rational therapy.<\/jats:p>","DOI":"10.36740\/merkur202302109","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T09:24:33Z","timestamp":1685525073000},"page":"156-160","source":"Crossref","is-referenced-by-count":7,"title":["TRAUMATIC EVENTS AND MENTAL DISEASES: THE ROLE OF CERTAIN NEUROTRANSMITTERS, METALLOENZYMES AND HORMONES. SYSTEMATIC LITERATURE REVIEW"],"prefix":"10.36740","volume":"51","author":[{"given":"Ivan R.","family":"Romash","sequence":"first","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna B.","family":"Romash","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kateryna V.","family":"Dzivak","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihor S.","family":"Tymkiv","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasyl Ye.","family":"Neyko","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor I.","family":"Vus","sequence":"additional","affiliation":[{"name":"AMERICAN PSYCHOLOGICAL ASSOCIATION, CONNECTICUT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykhaylo M.","family":"Pustovoyt","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Al Jowf GI, Ahmed ZT, An N et al. A Public Health Perspective of Post-Traumatic Stress Disorder. International Journal of Environmental Research and Public Health. International Journal of Environmental Research and Public Health. 2022;19(11):6474. doi:10.3390\/ijerph19116474.","DOI":"10.3390\/ijerph19116474"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Rosen V, Ayers G. An update on the complexity and importance of accurately diagnosing post-traumatic stress disorder and comorbid traumatic brain injury. Neurosci\u00acence insights. 2020;15: 2633105520907895. doi: 10.1177\/2633105520907895.","DOI":"10.1177\/2633105520907895"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Albani E, Strakantouna E, Vus V et al. The impact of mental health, subjective happiness and religious coping on the quality of life of nursing students during the COVID-19 pandemic. Wiadomosci Lekarskie. 2022; 75(2):678-684. doi: 10.36740\/WLek202203120.","DOI":"10.36740\/wlek202203120"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Romash I, Romash I, Kukhta O et al. Experience in correcting eating disorders in the clinic of mental illness. Mental Health: Global Challenges Journal 2021; 4(2). doi: 10.32437\/mhgcj.v4i2.127.","DOI":"10.32437\/mhgcj.v4i2.127"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Brewin CR. Complex post-traumatic stress disorder: a new diagnosis in ICD-11. B J Psych Advances. 2020; 26.(3): 145-152. doi: 10.1192\/bja.2019.48.","DOI":"10.1192\/bja.2019.48"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Lim ICZY, Tam WWS, Chudzicka-Czupa\u0142a A, et al. Prevalence of depression, anxiety and post-traumatic stress in war- and conflict-afflicted areas: A meta-analysis. Front. Psychiatry. Sec. Public Mental Health. 2022. doi: 10.3389\/fpsyt.2022.978703.","DOI":"10.3389\/fpsyt.2022.978703"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"7. Blinov O. Post-traumatic stress disorder screening questionnaire (PTSD SQ). Psychological journal. 2018; 4(1): 26-37. doi: 10.31108\/1.2018.1.11.2.","DOI":"10.31108\/1.2018.1.11.2"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Morina N, Akhtar A, Barth J, Schnyder U. Psychiatric Disorders in Refugees and Internally Displaced Persons After Forced Displacement: A Systematic Review. Front. Psychiatry. 2018; 9:433. doi: 10.3389\/fpsyt.2018.00433.","DOI":"10.3389\/fpsyt.2018.00433"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Mateos-Aparicio P, Rodr\u00edguez-Moreno A. The Impact of Studying Brain Plasticity. Front. Cell. Neurosci. 2019; 13:66. doi: 10.3389\/fncel.2019.00066.","DOI":"10.3389\/fncel.2019.00066"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Popova NK, Naumenko VS. Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem, Expert Opinion on Therapeutic Targets. 2019; 23(3): 227- 239. doi: 10.1080\/14728222.2019.1572747.","DOI":"10.1080\/14728222.2019.1572747"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Sur B, Lee B. Myricetin Inhibited Fear and Anxiety-Like Behaviors by HPA Axis Regulation and Activation of the BDNF-ERK Signaling Pathway in Posttraumatic Stress Disorder Rats. Hindawi. Evidence-Based Complementary and Alternative Medicine. 2022; 8320256. doi: 10.1155\/2022\/8320256.","DOI":"10.1155\/2022\/8320256"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Martinowich K, Lu B. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology. 2008; 33:73\u201383. doi: 10.1038\/sj.npp.1301571.","DOI":"10.1038\/sj.npp.1301571"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. Schweiger JI, Bilek E, Sch\u00e4fer A et al. Effects of BDNF Val66Met genotype and schizophrenia familial risk on a neural functional network for cognitive control in humans. Neuropsychopharmacol. 2019; 44:590\u2013597. doi: 10.1038\/s41386-018-0248-9.","DOI":"10.1038\/s41386-018-0248-9"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Notaras M, van den Buuse M. Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders. Mol Psychiatry. 2020; 25:2251\u20132274. doi: 10.1038\/s41380-019-0639-2.","DOI":"10.1038\/s41380-019-0639-2"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Spudic SD, Perkovic MN, Uzun S et al. Reduced plasma BDNF concentration and cognitive decline in veterans with PTSD. Psychiatry Research. 2022;316. doi: 10.1016\/j. psychres.2022.114772.","DOI":"10.1016\/j.psychres.2022.114772"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Mojtabavi H, Saghazadeh A, van den Heuvel L et al. Peripheral blood levels of brain-derived neurotrophic factor in patients with post-traumatic stress disorder (PTSD): A systematic review and meta-analysis. PLoS ONE. 2020; 15(11): e0241928. doi: 10.1371\/journal.pone.0241928.","DOI":"10.1371\/journal.pone.0241928"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Sun H, Zhang X, Kong Y et al. Maternal Separation-Induced Histone Acetylation Correlates with BDNF-Programmed Synaptic Changes in an Animal Model of PTSD with Sex Differences. Mol Neurobiol. 2021; 58:1738\u20131754. doi: 10.1007\/s12035-020-02224-6.","DOI":"10.1007\/s12035-020-02224-6"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. B\u00eelc MI, Vulturar R, Chi\u0219 A et al. Childhood trauma and emotion regulation: The moderator role of BDNF Val66Met. Neuroscience letters. 2018; 685:7-11. doi: 10.1016\/j. neulet.2018.07.018.","DOI":"10.1016\/j.neulet.2018.07.018"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. Dimitriadis M, van den Brink RHS, Comijs HC, Voshaar RO. Prognostic effect of serum BDNF levels in late-life depression: Moderated by childhood trauma and SSRI us\u00acage? Psychoneuroendocrinology. 2019;103:276-28. doi: 10.1016\/j.psyneuen.2019.02.003.","DOI":"10.1016\/j.psyneuen.2019.02.003"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. Diniz DM, Calabrese F, Brivio P et al. BDNF Overexpression in the Ventral Hippocampus Promotes Antidepressant- and Anxiolytic-Like Activity in Serotonin Transporter Knockout Rats. International Journal of Molecular Sciences. 2021; 22(9):5040. doi: 10.3390\/ijms22095040.","DOI":"10.3390\/ijms22095040"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Shokri-Mashhadi N, Darand M, Rouhani MH et al. Effects of melatonin supplementation on BDNF concentrations and depression: A systematic review and meta-analysis of randomized controlled trials. Behavioural Brain Research. 2022. doi: 10.1016\/j.bbr.2022.114083.","DOI":"10.1016\/j.bbr.2022.114083"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22. Hardeland R. Recent findings in melatonin research and their relevance to the CNS. Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents). 2018; 18(2):102-114. doi: 10.2174\/1871524918666180531083944.","DOI":"10.2174\/1871524918666180531083944"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23. Andrabi SS, Vishno S, Kaushik M et al. Reversal of schizophrenia-like symptoms and cholinergic alterations by melatonin. Archives of Medical Research. 2019; 50(5): 295-303. doi: 10.1016\/j.arcmed.2019.08.005.","DOI":"10.1016\/j.arcmed.2019.08.005"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24. Estrada-Reyes R, Quero-Ch\u00e1vez DB, Alarc\u00f3n-Elizalde S et al. Antidepressant Low Doses of Ketamine and Melatonin in Combination Produce Additive Neurogenesis in Human Olfactory Neuronal Precursors. Molecules. 2022; 27(17):5650. doi: 10.3390\/molecules27175650.","DOI":"10.3390\/molecules27175650"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Mansouri S, Salari AA, Abedi A et al. Melatonin treatment improves cognitive deficits by altering inflammatory and neurotrophic factors in the hippocampus of obese mice. Physiology & Behavior. 2022; 254:113919. doi: 10.1016\/j.physbeh.2022.113919.","DOI":"10.1016\/j.physbeh.2022.113919"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26. Mahbod P, Smith EP, Fitzgerald ME et al. Desacyl Ghrelin decreases anxiety-like behavior in male mice. Endocrinology. 2018; 159:388\u2013399. doi: 10.1210\/en.2017-00540.","DOI":"10.1210\/en.2017-00540"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Yong-Hong Li, Liu Qing-Xiu, Ji-Sheng Wang et al. Huang Ghrelin improves cognition via activation of the cAMP- CREB signalling pathway in depressed male C57BL\/6J mice, International Journal of Neuroscience. 2021. doi: 10.1080\/00207454.2021.1928114.","DOI":"10.1080\/00207454.2021.1928114"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28. Fritz EM, Singewald N, De Bundel D. The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders. Frontiers in Synaptic Neuroscience. Frontiers Media S.A. 2020. doi: 10.3389fnsyn.","DOI":"10.3389\/fnsyn.2020.594484"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29. Jee Y Lee, Hae Y Choi, Won H Na et al. Yune. Ghrelin inhibits BSCB disruption\/hemorrhage by attenuating MMP-9 and SUR1\/TrpM4 expression and activation after spinal cord injury. Biochimica et Biophysica Acta (BBA) \u2013 Molecular Basis of Disease. 2014; 1842(12): 2403-2412. doi: 10.1016\/j.bbadis.2014.09.006.","DOI":"10.1016\/j.bbadis.2014.09.006"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30. Romash I. Peculiarities of the course ad treatment of gastroesophageal reflux disease I patiets with syndrome of udifferetiated connective tissue dysplasia. (systematic literature review). Mental Health: Global Challenges Journal 2019; 2(0): 76-86. doi: 10.32437\/MHGCJ-2019(0).70.","DOI":"10.32437\/mhgcj-2019(0).70"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"31. Lu Y, Wahl LM. Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and pros- taglandin E2 through enhancement of NF-kappa B activity in lipopolysaccharide-activated human primary monocytes. J Immunol. 2005; 175(8): 5423-9. doi: 10.4049\/jimmunol.175.8.5423.","DOI":"10.4049\/jimmunol.175.8.5423"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"32. R\u00e8gue M, Poilbout C, Martin V et al. Increased 5-HT2C receptor editing predisposes to PTSD-like behaviors and alters BDNF and cytokines signaling. Translational psychia\u00actry. 2019; 9(1):1-15. doi: 10.1038\/s41398-019-0431-8.","DOI":"10.1038\/s41398-019-0431-8"}],"container-title":["Polski Merkuriusz Lekarski"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T09:25:39Z","timestamp":1685525139000},"score":1,"resource":{"primary":{"URL":"https:\/\/polskimerkuriuszlekarski.pl\/wp-content\/uploads\/library\/PolMerkurLek202302.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.36740\/merkur202302109","archive":["Internet Archive"],"relation":{},"ISSN":["1426-9686"],"issn-type":[{"value":"1426-9686","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}