{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:01:51Z","timestamp":1762300911388,"version":"3.37.1"},"reference-count":29,"publisher":"ALUNA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Aim: To study the histostructure of bone tissue in case of disruption of its blood supply and after restored blood flow in patients with ischemic form of diabetic foot syndrome.\nMaterials and Methods: The histostructure of bone fragments in 25 patients with isolated ischemic form of diabetic foot syndrome was studied. Bone tissue biopsy specimens from 6 patients against the background of progressive ischemia were studied. In addition, the histostructure of bone tissue after revascularization with complete restoration of blood flow in 19 patients was studied.\nResults: The analysis of bone tissue biopsy specimens showed that disruption of blood supply of the limb tissues for a long time leads to impaired matrix calcification, decreased cortex thickness, widening of osteon channels and sparse trabecular network in the bone structure. Such changes were the signs of bone resorption that was not clinically or radiologically apparent. Revascularization with full restoration of blood flow promoted the appearance of signs of bone tissue regeneration in the form of vessel formation in bone and periosteum.\nConclusions: Adequate blood flow is an important clinical factor contributing to the restoration of bone regeneration in patients with ischemic form of diabetic foot syndrome.<\/jats:p>","DOI":"10.36740\/merkur202406103","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T13:02:14Z","timestamp":1739624534000},"page":"630-637","source":"Crossref","is-referenced-by-count":1,"title":["Histostructure of bone tissue after restoration of blood flow in patients with ischemic form of diabetic foot syndrome"],"prefix":"10.36740","volume":"52","author":[{"given":"Tamara I.","family":"Tamm","sequence":"first","affiliation":[{"name":"KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentyn V.","family":"Nepomniashchyi","sequence":"additional","affiliation":[{"name":"KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey B.","family":"Pavlov","sequence":"additional","affiliation":[{"name":"KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan M.","family":"Mamontov","sequence":"additional","affiliation":[{"name":"KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena A.","family":"Shakalova","sequence":"additional","affiliation":[{"name":"KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga B.","family":"Litvinova","sequence":"additional","affiliation":[{"name":"KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Liao X, Li SH, El Akkawi MM et al. Surgical amputation for patients with diabetic foot ulcers: A Chinese expert panel consensus treatment guide. Front Surg. 2022;9:1003339. doi:10.3389\/fsurg.2022.1003339.","DOI":"10.3389\/fsurg.2022.1003339"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Hinchliffe RJ, Brownrigg JR, Apelqvist J et al. IWGDF guidance on the diagnosis, prognosis and management of peripheral artery disease in patients with foot ulcers in diabetes. Diabetes Metab Res Rev. 2016;32(1):37-44. doi:10.1002\/dmrr.2698.","DOI":"10.1002\/dmrr.2698"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Malhotra R, Chan CS, Nather A. Osteomyelitis in the diabetic foot. Diabet Foot Ankle. 2014;5(1). doi:10.3402\/dfa.v5.24445.","DOI":"10.3402\/dfa.v5.24445"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Hristich T, Hontsariuk D, Teleki Y et al. Features of the Clinical Course of Osteoarthritis in Combination with Diabetes Mellitus. Wiad Lek. 2023;76(1):161-169. doi:10.36740\/WLek202301122.","DOI":"10.36740\/wlek202301122"},{"key":"ref4","unstructured":"5. Tamm TI, Belov SG, Pavlov SB et al. Dynamics of bone tissue histostructure in patients with purulent-necrotic complications of diabetic foot syndrome after angiocorrection. Surgery. Eastern Europe. 2016;5(3):360-366."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"6. Apelqvist J, Bakker K, van Houtum WH et al. International consensus and practical guidelines on the management and the prevention of the diabetic foot. International Working Group on the Diabetic Foot. Diabetes Metab Res Rev. 2000;16(1):S84-92. doi: 10.1002\/1520-7560(200009\/10)16:1+<::aid-dmrr113>3.0.co;2-s.","DOI":"10.1002\/1520-7560(200009\/10)16:1+<::AID-DMRR113>3.0.CO;2-S"},{"key":"ref6","unstructured":"7. Unifikovanyy klinichnyy protokol pervynnoyi ta vtorynnoyi medychnoyi dopomohy. Tsukrovyy diabet 2 typu, zatverdzhenyy nakazom MOZ Ukrayiny \u2116 1118 vid 21.12.2012 r. [Unified clinical protocol of primary and secondary medical care. Type 2 diabetes mellitus, approved by the order of the Ministry of Health of Ukraine No. 1118 dated 12\/21\/2012]. https:\/\/zakononline.com.ua\/documents\/show\/8047___730659. [Accessed 14 June 2024] (Ukrainian)"},{"key":"ref7","unstructured":"8. Proceedings of the First International Symposium on the Diabetic Foot, Noordwijkerkout, The Netherlands, 3-4 May, 1991. Ed Excerpta Medica."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191-2194. doi: 10.1001\/jama.2013.281053.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. M\u00e9tairie A, Tollenaere Q, Lan\u00e9elle D et al. Simplification of ankle-brachial-index measurement using Doppler-waveform classification in symptomatic patients suspected of lower extremity artery disease. Front Cardiovasc Med. 2022;9:941600. doi: 10.3389\/fcvm.2022.941600.","DOI":"10.3389\/fcvm.2022.941600"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Lavery LA, Armstrong DG, Harkless LB. Classification of diabetic foot wounds. J Foot Ankle Surg. 1996;35(6):528-531. doi:10.1016\/S1067-2516(96)80125-6.","DOI":"10.1016\/s1067-2516(96)80125-6"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Norgren L, Hiatt WR, Dormandy JA et al. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg. 2007;45(1):S5-67. doi:10.1016\/j.jvs.2006.12.037.","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"ref12","unstructured":"13. Nakaz MOZ Ukrayiny \u2116 574 vid 05.08.2009r. [Order of the Ministry of Health of Ukraine No. 574 dated 08\/05\/2009]. https:\/\/zakononline.com.ua\/documents\/show\/48894___48894. [Accessed 14 June 2024] (Ukrainian)"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Dyck PJ, Albers JW, Andersen H et al. Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity. Diabetes Metab Res Rev. 2011;27(7):620-628. doi: 10.1002\/dmrr.1226.","DOI":"10.1002\/dmrr.1226"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Field JR, Sumner-Smith G. Bone blood flow response to surgical trauma. Injury. 2002;33(5):447-451. doi:10.1016\/s0020-1383(02)00014-1.","DOI":"10.1016\/s0020-1383(02)00014-1"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"16. Draghici AE, Taylor JA. Mechanisms of bone blood flow regulation in humans. J Appl Physiol (1985). 2021;130(3):772-780. doi:10.1152\/japplphysiol.00595.2020.","DOI":"10.1152\/japplphysiol.00595.2020"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Tomlinson RE, Silva MJ. Skeletal Blood Flow in Bone Repair and Maintenance. Bone Res. 2013;1(4):311-322. doi:10.4248\/BR201304002.","DOI":"10.4248\/br201304002"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. Prisby RD. Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone. J Endocrinol. 2017;235(3):R77-R100. doi:10.1530\/JOE-16-0666.","DOI":"10.1530\/joe-16-0666"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. Hendriks M, Ramasamy SK. Blood Vessels and Vascular Niches in Bone Development and Physiological Remodeling. Front Cell Dev Biol. 2020;8:602278. doi:10.3389\/fcell.2020.602278.","DOI":"10.3389\/fcell.2020.602278"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. Stabley JN, Prisby RD, Behnke BJ et al. Type 2 diabetes alters bone and marrow blood flow and vascular control mechanisms in the ZDF rat. J Endocrinol. 2015;225(1):47-58. doi:10.1530\/JOE-14-0514.","DOI":"10.1530\/joe-14-0514"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Travis C, Srivastava PS, Hawke TJ et al. Diabetic Bone Disease and Diabetic Myopathy: Manifestations of the Impaired Muscle-Bone Unit in Type 1 Diabetes. J Diabetes Res. 2022;2022:2650342. doi:10.1155\/2022\/2650342.","DOI":"10.1155\/2022\/2650342"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22. Le T, Salas Sanchez A, Nashawi D et al. Diabetes and the Microvasculature of the Bone and Marrow. Curr Osteoporos Rep. 2024;22(1):11-27. doi:10.1007\/s11914-023-00841-3.","DOI":"10.1007\/s11914-023-00841-3"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23. Almutlaq N, Neyman A, DiMeglio LA. Are diabetes microvascular complications risk factors for fragility fracture? Curr Opin Endocrinol Diabetes Obes. 2021;28(4):354-359. doi:10.1097\/MED.0000000000000642.","DOI":"10.1097\/med.0000000000000642"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24. Filipowska J, Tomaszewski KA, Nied\u017awiedzki \u0141 et al. The role of vasculature in bone development, regeneration and proper systemic functioning. Angiogenesis. 2017;20(3):291-302. doi:10.1007\/s10456-017-9541-1.","DOI":"10.1007\/s10456-017-9541-1"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Shanbhogue VV, Hansen S, Frost M et al. Bone disease in diabetes: another manifestation of microvascular disease? Lancet Diabetes Endocrinol. 2017;5(10):827-838. doi:10.1016\/S2213-8587(17)30134-1.","DOI":"10.1016\/s2213-8587(17)30134-1"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26. Zhakubayev M, Yegemberdiyev TZ, Tolegen AI et al. Optimal tactics for surgical revascularisation in diabetic angiopathy of the lower limbs. Pol Merkur Lek. 2024;53(4):415-420. . doi: 10.36740\/Merkur202404105.","DOI":"10.36740\/merkur202404105"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Shapovalov D, Hupalo Y, Shaprynskyi V et al. Features of revascularization of the lower extremity in patients with diabetic foot. Clinical and Preventive Medicine. 2020;3:35-44. doi:10.31612\/2616-4868.3(13).2020.04.","DOI":"10.31612\/2616-4868.3(13).2020.04"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28. Balasubramanian GV, Chockalingam N, Naemi R. The Role of Cutaneous Microcirculatory Responses in Tissue Injury, Inflammation and Repair at the Foot in Diabetes. Front Bioeng Biotechnol. 2021;9:732753. doi:10.3389\/fbioe.2021.732753.","DOI":"10.3389\/fbioe.2021.732753"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29. Shapovalov D. Choice of revascularization technique in patients with ischemic diabetic foot. Clinical and Preventive Medicine. 2021;4:18\u201326. doi:10.31612\/2616-4868.4(18).2021.03.","DOI":"10.31612\/2616-4868.4(18).2021.03"}],"container-title":["Polski Merkuriusz Lekarski"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T13:02:20Z","timestamp":1739624540000},"score":1,"resource":{"primary":{"URL":"https:\/\/polskimerkuriuszlekarski.pl\/wp-content\/uploads\/library\/PolMerkurLek2024i6net.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024]]},"published-print":{"date-parts":[[2024,12]]}},"URL":"https:\/\/doi.org\/10.36740\/merkur202406103","archive":["Internet Archive"],"relation":{},"ISSN":["1426-9686"],"issn-type":[{"value":"1426-9686","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}