{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T14:40:09Z","timestamp":1741704009682,"version":"3.38.0"},"reference-count":25,"publisher":"ALUNA","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Aim: This review aims to analyze scientific articles and publications on the role of oxidative stress and xanthine oxidase in the pathogenesis of type 1 diabetes mellitus and diabetic nephropathy in order to update the theories underlying its development and progression.\nMaterials and Methods: The literature analysis used peer-reviewed articles, reviews, and descriptions of experimental studies from 2021-2024. The study describes the role of oxidative damage in the pathogenesis of diabetic nephropathy and the function of xanthine oxidase as a trigger.\nConclusions: The study of the molecular mechanisms of the cytoprotective and renoprotective effects of xanthine oxidase inhibition confirms its leading role in the pathogenesis of diabetic nephropathy and opens up new prospects for the development of biomarkers, and therefore new approaches in the diagnosis, treatment, and prevention of diabetes and its dangerous complications.<\/jats:p>","DOI":"10.36740\/merkur202501115","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:58:13Z","timestamp":1741701493000},"page":"108-114","source":"Crossref","is-referenced-by-count":0,"title":["The role of oxidative disorders in the pathogenesis of kidney damage in type 1 diabetes mellitus and diabetic nephropathy in children: xanthine oxidase as a trigger"],"prefix":"10.36740","volume":"53","author":[{"given":"Ievgeniia A.","family":"Burlaka","sequence":"first","affiliation":[{"name":"BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ihor V.","family":"Kovalchuk","sequence":"additional","affiliation":[{"name":"BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga O.","family":"Mityuryayeva-Kornijko","sequence":"additional","affiliation":[{"name":"BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Sun H, Karuranga S, Saeedi P. IDF Diabetes Atlas: Diabetes Trends 2021-2045. Diabetes Res Clin Pract. 2022;184:109119. doi: 10.1016\/j.diabres.2021.109119.","DOI":"10.1016\/j.diabres.2023.110945"},{"key":"ref1","unstructured":"2. WHO. Diabetes Prevalence and Projections to 2045: IDF Atlas. https:\/\/www.idf.org\/e-library\/ [Accessed 30 Desember 2024]."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Sun H, Saeedi P, Karuranga S et al. IDF Diabetes Atlas: Global, Regional and Country-Level Diabetes Prevalence Estimates for 2021 and Projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. doi: 10.1016\/j.diabres.2021.109119.","DOI":"10.1016\/j.diabres.2023.110945"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Umanath K, Lewis JB. Update on Diabetic Nephropathy: Core Curriculum 2018. Am J Kidney Dis. 2018;71(6):884-895. doi: 10.1053\/j.ajkd.2017.10.026.","DOI":"10.1053\/j.ajkd.2017.10.026"},{"key":"ref4","unstructured":"5. 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