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In vestibuloplasty, it has been demonstrated to enhance vestibular deepening, accelerate epithelialisation and reduce pain. In periodontics, it has been shown to be an effective treatment for gingival recession and furcation defects, and to increase the width of keratinised gingiva around implants. In endodontics, it is employed in regenerative procedures, offering comparable results to standard methods. Furthermore, in the treatment of osteoarthritis of the temporomandibular joint, it has been observed to provide pain relief and improved joint function.<\/jats:p>","DOI":"10.36740\/merkur202501116","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:58:15Z","timestamp":1741701495000},"page":"115-119","source":"Crossref","is-referenced-by-count":1,"title":["Use of amniotic membranes in dentistry \u2013 literature review"],"prefix":"10.36740","volume":"53","author":[{"given":"Justyna","family":"Talaska","sequence":"first","affiliation":[{"name":"DEPARTMENT OF CONSERVATIVE DENTISTRY WITH ENDODONTICS, FACULTY OF MEDICAL SCIENCES, SILESIAN MEDICAL UNIVERSITY IN KATOWICE, KATOWICE, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Niemczyk","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF CONSERVATIVE DENTISTRY WITH ENDODONTICS, MEDICAL UNIVERSITY OF SILESIA, FACULTY OF MEDICAL SCIENCE IN ZABRZE, ZABRZE, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Demel","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF CONSERVATIVE DENTISTRY WITH ENDODONTICS, FACULTY OF MEDICAL SCIENCES, SILESIAN MEDICAL UNIVERSITY IN KATOWICE, KATOWICE, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Aboud","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF CONSERVATIVE DENTISTRY WITH ENDODONTICS, MEDICAL INNOVATION CENTRE, WROCLAW, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Dziedzic","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF CONSERVATIVE DENTISTRY WITH ENDODONTICS, FACULTY OF MEDICAL SCIENCES, SILESIAN MEDICAL UNIVERSITY IN KATOWICE, KATOWICE, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Kr\u00f3l","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF CONSERVATIVE DENTISTRY WITH ENDODONTICS, FACULTY OF MEDICAL SCIENCES, SILESIAN MEDICAL UNIVERSITY IN KATOWICE, KATOWICE, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja","family":"Zawadzka","sequence":"additional","affiliation":[{"name":"ST. LUKE\u2019S PROVINCIAL HOSPITAL, TARNOW, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zawilska","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF CONSERVATIVE DENTISTRY WITH ENDODONTICS, MEDICAL UNIVERSITY OF SILESIA, FACULTY OF MEDICAL SCIENCE IN ZABRZE, ZABRZE, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Song M, Wang W, Ye Q, Bu S, Shen Z, Zhu Y. The Repairing of Full-Thickness Skin Deficiency and Its Biological Mechanism Using Decellularized Human Amniotic Membrane as the Wound Dressing. Mater Sci Eng C Mater Biol Appl. 2017;77:739-747. doi:10.1016\/j.msec.2017.03.232.","DOI":"10.1016\/j.msec.2017.03.232"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Mamede AC, Carvalho MJ, Abrantes AM, Laranjo M, Maia CJ, Botelho MF. Amniotic Membrane: From Structure and Functions to Clinical Applications. Cell Tissue Res 2012;349:447-458. doi:10.1007\/s00441-012-1424-6.","DOI":"10.1007\/s00441-012-1424-6"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"3. Dua HS, Azuara-Blanco A. Amniotic Membrane Transplantation. Br J Ophthalmol. 1999;83:748-752. doi:10.1136\/bjo.83.6.748.","DOI":"10.1136\/bjo.83.6.748"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Dawiec G, Niemczyk W, Wiench R, Niemczyk S, Skaba D. Introduction to Amniotic Membranes in Maxillofacial Surgery \u2013 A Scoping Review. Medicina 2024;60:663. doi:10.3390\/medicina60040663.","DOI":"10.3390\/medicina60040663"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Lubaib M, Dhawan S, Sharma E, et al. A Meta-Analysis of Amnion Membrane in Gingival Recession. Bioinformation 2023;19:670-678. doi:10.6026\/97320630019670.","DOI":"10.6026\/97320630019670"},{"key":"ref5","unstructured":"6. Kubo M, Sonoda Y, Muramatsu R, Usui M. Immunogenicity of Human Amniotic Membrane in Experimental Xenotransplantation. Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1539-46."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Gholipourmalekabadi M, Farhadihosseinabadi B, Faraji M, Nourani MR. How Preparation and Preservation Procedures Affect the Properties of Amniotic Membrane? How Safe Are the Procedures? Burns 2020;46:1254-1271. doi:10.1016\/j.burns.2019.07.005.","DOI":"10.1016\/j.burns.2019.07.005"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. \u017burek J, Niemczyk W, Dominiak M, Niemczyk S, Wiench R, Skaba D. Gingival Augmentation Using Injectable Platelet-Rich Fibrin (i-PRF) \u2013 A Systematic Review of Randomized Controlled Trials. JCM 2024;13:5591. doi:10.3390\/jcm13185591.","DOI":"10.3390\/jcm13185591"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Niemczyk W, Janik K, \u017burek J, Skaba D, Wiench R. 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Johns Hopkins Med J. 1910;15:307-396."},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. Fenelon MB, Maurel D, Siadous R, et al. Comparison of the Impact of Preservation Methods on Amniotic Membrane Properties for Tissue Engineering Applications. Mater Sci Eng C Mater Biol Appl. 2019;104:109903. doi:10.1016\/j.msec.2019.109903.","DOI":"10.1016\/j.msec.2019.109903"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Lawson VG. Oral Cavity Reconstruction Using Pectoralis Major Muscle and Amnion. Arch Otolaryngol. 1985;111;230-233. doi:10.1001\/archotol.1985.00800060054006","DOI":"10.1001\/archotol.1985.00800060054006"},{"key":"ref14","unstructured":"15. Kadkhoda Z, Tavakoli A, Chokami Rafiei S, Zolfaghari F, Akbari S. Effect of Amniotic Membrane Dressing on Pain and Healing of Palatal Donor Site: A Randomized Controlled Trial. Int J Org Transplant Med. 2020;11(2):55-62."},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Sharma S, Mehra H, Gupta H, Agarwal R, Gangwar A. Kumar A. Comparison of the Efficacy of Amniotic Membrane Versus Buccal Fat Pad in Treatment of Oral Submucous Fibrosis. J Maxillofac Oral Surg. 2023 Sep;22(3):525-532. doi:10.1007\/s12663-022-01709-2.","DOI":"10.1007\/s12663-022-01709-2"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Kar IB, Singh AK, Mohapatra PC, Mohanty PK, Misra S. Repair of Oral Mucosal Defects with Cryopreserved Human Amniotic Membrane Grafts: Prospective Clinical Study. Int J Oral Maxillofac Surg. 2014;43:1339-1344. doi:10.1016\/j.ijom.2014.07.018.","DOI":"10.1016\/j.ijom.2014.07.018"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. Rohleder NH, Loeffelbein DJ, Feistl W, et al. Repair of Oronasal Fistulae by Interposition of Multilayered Amniotic Membrane Allograft. Plastic Reconstr Surg. 2013;132:172-181. doi:10.1097\/PRS.0b013e3182910b50.","DOI":"10.1097\/prs.0b013e3182910b50"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. Holtzclaw D. Maxillary Sinus Membrane Repair With Amnion-Chorion Barriers: A Retrospective Case Series. J Periodontol. 2015;86:936-940. doi:10.1902\/jop.2015.140087c.","DOI":"10.1902\/jop.2015.140087c"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. Tsuno H, Noguchi M, Okabe M, Tomihara K, Yoshida T, Nikaido T. Use of Hyperdry Amniotic Membrane in Operations for Cleft Palate: A Study in Rats. Br J Oral Maxillofac Surg. 2015;53:358-363. doi:10.1016\/j.bjoms.2015.01.018.","DOI":"10.1016\/j.bjoms.2015.01.018"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Fujiwara K, Tsuno H, Okabe M, Yoshida T, et al. Clinical Application of Hyperdry Amniotic Membrane in Cleft Palate Repair. 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Fenelon M, Etchebarne M, Siadous R, et al. Assessment of Fresh and Preserved Amniotic Membrane for Guided Bone Regeneration in Mice. J Biomedical Mater Res. 2020:108:2044-2056. doi:10.1002\/jbm.a.36964.","DOI":"10.1002\/jbm.a.36964"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Karas M, Gunpinar S. The Use of Low Level Laser Therapy in Conjunction with Diode Laser-Assisted and Conventional Vestibuloplasty: Comparison of Wound Healing and Vestibular Depth Gain. J Stomatol Oral Maxillofac Surg. 2023;124:101476. doi:10.1016\/j.jormas.2023.101476.","DOI":"10.1016\/j.jormas.2023.101476"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26. G\u00fcler R, Ercan MT, Ulutun\u00e7el N, Devrim H, Uran N. Measurement of Blood Flow by the 133Xe Clearance Technique to Grafts of Amnion Used in Vestibuloplasty. Br J Oral Maxillofac Surg. 1997;35:280-283. doi:10.1016\/S0266-4356(97)90048-6.","DOI":"10.1016\/s0266-4356(97)90048-6"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Sikkerimath B, Dandagi S, Gudi S, Jayapalan D. Comparison of Vestibular Sulcus Depth in Vestibuloplasty Using Standard Clark's Technique with and without Amnion as Graft Material. Ann Maxillofac Surg. 2012;2:30. doi:10.4103\/2231-0746.95313.","DOI":"10.4103\/2231-0746.95313"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28. Sacco R, Akintola O, Sacco N, et al.The Use of Human Amniotic Membrane (HAM) as a Treatment Strategy of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Systematic Review and Meta-Analysis of the Literature. Medicina 2023;59:968. doi:10.3390\/medicina59050968.","DOI":"10.3390\/medicina59050968"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29. \u00c7anak\u00e7i FG, Er N, Duygu G, Varol GF. Surgical Management of Stage-2 Medication-Related Osteonecrosis of the Jaw with Transplantation of Human Amniotic Membrane: Preliminary Results. J Stomatol Oral Maxillofac Surg. 2022;123:e28-e31. doi:10.1016\/j.jormas.2021.09.011.","DOI":"10.1016\/j.jormas.2021.09.011"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30. Niemczyk W, Niemczyk S, Prokurat M, et al. Etiology of Gingival Recession \u2013 a Literature Review. Wiad Lek. 2024;77:1080-1085. doi: 10.36740\/WLek202405131.","DOI":"10.36740\/wlek202405131"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"31. Rana PM, Mehrotra N. Human Amniotic Membrane: Hope in Periodontal Regeneration. IJSR 2016;5:564-569. doi:10.21275\/v5i4.NOV162635.","DOI":"10.21275\/v5i4.nov162635"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"32. Chakraborthy S, Samba Shivaiah S, Kulal R, Bilchodmath S. Amnion and Chorion Allografts in Combination with Coronally Advanced Flap in the Treatment of Gingival Recession: A Clinical Study. J Clin Diagn Res. 2015 Sep;9(9):ZC98-ZC101. doi:10.7860\/JCDR\/2015\/12971.6572.","DOI":"10.7860\/jcdr\/2015\/12971.6572"},{"key":"ref32","unstructured":"33. Taalab MR, Gamal RM. The Effect of Amniotic Chorion Membrane on Tissue Biotype, Wound Healing and Periodontal Regeneration. IOSR-JDMS 2018;12:61-69."},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"34. Mallapragda S, Gupta S, Srivastava S, et al. Evaluation of Regenerative Efficacy of Amnion and Chorion Membrane in Treatment of Mandibular Molar Furcation Defects: A Clinico-Radiographic Study. J Contemp Dent Pract. 2024;25:160-167. doi:10.5005\/jp-journals-10024-3640.","DOI":"10.5005\/jp-journals-10024-3640"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"35. Gamal RM, Lotfy M, Taalab M. Evaluation of the efficacy of amniotic chorion membrane in management of grade II furcation defects (clinical study). Alex Dent J. 2018;43:102-108. doi:10.21608\/adjalexu.2018.58007.","DOI":"10.21608\/adjalexu.2018.58007"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"36. De Angelis N, Kassim Z, Frosecchi M, Signore A. Expansion of the Zone of Keratinized Tissue for Healthy Implant Abutment Interface Using De-Epithelialized Amnion\/Chorion Allograft. Int J Periodontics Restorative Dent 2019;39:e83-e88. doi:10.11607\/prd.3757.","DOI":"10.11607\/prd.3757"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"37. Suresh N, Arul B, Kowsky D, Natanasabapathy V. Successful Regenerative Endodontic Procedure of a Nonvital Immature Permanent Central Incisor Using Amniotic Membrane as a Novel Scaffold. Dent J. 2018;6:36. doi:10.3390\/dj6030036.","DOI":"10.3390\/dj6030036"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"38. Johri S, Verma P, Bains R. Potential Applications of the Human Amniotic Membrane in Endodontics: A Case Series of Three Different Procedures. Endodontology 2024;36:80-85. doi:10.4103\/endo.endo_11_23.","DOI":"10.4103\/endo.endo_11_23"},{"key":"ref38","unstructured":"39. Prasad MG, Adiya P, Babu DN, RadhaKrishna AN. Amniotic Membrane versus Formocresol as Pulpotomy Agents in Human Primary Molars: An in Vivo Study. Pesquisa Brasileira em Odontopediatria e Clinica Integrada 2017;17:1-8."},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"40. Beltagy T, Yasser S. Clinical, Radiographical and Histopathological Evaluation of Amniotic Membrane Allograft Pulpotomy in Primary Teeth. Egypt Dent J. 2019;65:3179-3197. doi:10.21608\/edj.2019.73995.","DOI":"10.21608\/edj.2019.73995"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"41. Tuncel U, Ozgenel GY. Use of Human Amniotic Membrane as an Interpositional Material in Treatment of Temporomandibular Joint Ankylosis. J Oral Maxillofac Surg. 2011;69:e58-e66. doi:10.1016\/j.joms.2010.12.044.","DOI":"10.1016\/j.joms.2010.12.044"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"42. Tuncel U, Kostakoglu N, Turan A, et al. The Use of Temporalis Muscle Graft, Fresh and Cryopreserved Amniotic Membrane in Preventing Temporomandibular Joint Ankylosis after Discectomy in Rabbits. J Craniomaxillofac Surg. 2014;42:1868-1876. doi:10.1016\/j.jcms.2014.07.005.","DOI":"10.1016\/j.jcms.2014.07.005"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"43. Akhter M, Ahmed N, Arefin MR, et al.Outcome of Amniotic Membrane as an Interpositional Arthroplasty of TMJ Ankylosis. 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